Effect of sanguinarine in drinking water on Salmonella control and the expression of immune cells in peripheral blood and intestinal mucosa of broilers

Pickler, Larissa; Beirão, Breno Castello Branco; Hayashi, R. M.; Durau, J. F.; Lourenço, Miguel L.; Caron, Luíz Felipe; Santín, Elizabeth

doi:10.3382/japr.2012-00649

Cited by 35 publications

(29 citation statements)

References 31 publications

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“…Berndt & Methner (2001) observaram em frangos inoculados com ST, aumento destas células no ceco nos primeiros 9 dias PI comparado com o controle. Observa-se que aves desafiadas com SE apresentam aumento na quantidade de linfócitos T CD3+ (Pickler et al 2013) e CD8+ (Berndt et al 2006) na mucosa intestinal e redução dessas células na circulação sanguínea concluindo que rapidamente essas células migram do sangue ao intestino, primeiro sítio de infecção da Salmonella.…”

Section: Discussionunclassified

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

et al. 2015

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RESUMO.-Objetivou-se com o presente estudo comparar o efeito de diferentes sorovares de Salmonella na resposta imune local da mucosa do intestino de frangos de corte. Aos sete dias de idade, as aves foram desafiadas com os sorovares S. Enteritidis, S. Typhimurium, S. Senftenberg, S. Mbandaka e S. Minnesota. Foi observado que todos os sorovares testados foram capazes de colonizar o intestino das aves sendo possível o isolamento de Salmonella em suabes de cloaca, 48 h após inoculação. De maneira geral, as aves do grupo controle negativo, que não foram desafiados apresentaram quantidade significativamente menor de células imunológicas na mucosa intestinal do que as aves desafiadas. Porém, verificou--se que os sorovares de Salmonella, utilizados neste estudo, apresentaram diferentes efeitos sobre a dinâmica celular da mucosa do íleo e ceco e afetaram de modo diferente o ganho de peso e ganho médio diário das aves demonstrando distintos graus de patogenicidade. Os sorovares Enteritidis e Typhimurium apresentaram um efeito mais intenso tanto no desempenho quanto na mobilização de células imunoló-gicas na mucosa intestinal de frangos de corte. The study was designed to compare the effect of different Salmonella serovars in immune response across the count of CD8+ cells, CD4+ cells, goblet cells and macrophages in the gut mucosa of broilers. During the experimental inoculation at 7 day-old were used Salmonella enterica subspecies enterica sorovars Enteritidis, Typhimurium, Senftenberg, Mbandaka and Minnesota. It was observed that all serovars tested were capable of contaminating the poultry being possible counts of Salmonella in cloacal swabs, 48 h after inoculation and into the crop and cecum, at 14 and 20 day-old. Serovars tested had different effects on broiler performance assessed at 20 days. In the mucosa of the ileum and cecum of broilers, it was observed that some of the serotypes increased CD8 + cells, CD4 + cells, goblet cells and macrophages compared to the negative control group both at 14 and at 20 day-old. S. Enteritidis and S. Typhimurium are the serovars that showed the more intense effect in live performance and in the immune system of birds showing pathogenic characteristic; generally the broilers of the negative control showed significantly less immune cells on the intestinal mucosa than broilers inoculated experimentally. However, it was found that the Salmonella serovars used in this study had different effects on the cellular dynamics of the mucosa of the ileum and cecum and differently affect weight gain and average daily gain of poultry showing different levels of pathogenicity. Avaliação da resposta imunológica da mucosa intestinal

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Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

et al. 2015

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“…is a common inhabitant of the intestine of broilers, as described Muniz (2014). Pickler et al (2013) reported that, although benzophenanthridine and protopine alkaloids did not reduce Salmonella Enteritidis counts in the excreta of broilers 48 hours after inoculation, counts significantly decreased in cecal samples seven days after inoculation. Santiago et al (2014) also observed a significant difference in Salmonella Typhimurium counts, but only in the group of broilers that were challenged and were not fed BPA, differently from the present study, where no significant differences were observed between the challenged and not challenged groups and that received or not BPA in drinking water.…”

Section: Assessment Of Benzophenanthridine and Protopine Alkaloids Inmentioning

confidence: 96%

“…On the other hand, Pickler et al (2013), studying the effect of BPA supplied in the drinking water (100 ppm of product) for the control of Salmonella Enteritidis found lower (p<0.05) villus height and crypt depth in the jejunum of challenged broilers receiving BPA compared with the control group, but no differences in jejunal villus:crypt ratio or goblet cell count in the ceca. Likewise, Jankowski et al (2009) observed that broilers fed with a diet containing 20 ppm of a BPA product presented a significant reduction of villus height compared with the control group.…”

Section: Assessment Of Benzophenanthridine and Protopine Alkaloids Inmentioning

confidence: 97%

“…Although higher villi are related with better nutrient absorption under experimental conditions in the absence of challenge, the types of cells present in the villi are as important as their height (Pickler et al, 2013). Goblet cells secrete glycoproteins (mucus), which are responsible for protecting the intestinal epithelium against dietary abrasive agents and pathogens, as well as participating in the absorption of nutrients (Pickler et al 2011;Pickler et al, 2013).…”

Section: Assessment Of Benzophenanthridine and Protopine Alkaloids Inmentioning

confidence: 99%

“…Goblet cells secrete glycoproteins (mucus), which are responsible for protecting the intestinal epithelium against dietary abrasive agents and pathogens, as well as participating in the absorption of nutrients (Pickler et al 2011;Pickler et al, 2013).…”

Section: Assessment Of Benzophenanthridine and Protopine Alkaloids Inmentioning

confidence: 99%

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Sanguinarine improved nutrient digestibility, hepatic health indices and productive performance in laying hens fed low crude protein diets

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Effect of sanguinarine in drinking water on Salmonella control and the expression of immune cells in peripheral blood and intestinal mucosa of broilers

Cited by 35 publications

References 31 publications

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

Assessment of Benzophenanthridine and Protopine Alkaloids in Broiler Challenged and Not by Salmonella Heidelberg

Sanguinarine improved nutrient digestibility, hepatic health indices and productive performance in laying hens fed low crude protein diets

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