Effect of Salt Intake on Plasma and Urinary Uric Acid Levels in Chinese Adults

Wang, Y.; Chu, Cordia Ming-Yeuk; Wang, K.-K.; Hu, Janka; Yan, Yuan-Horng; Lv, Yang; Cao, Yong; Zheng, Wan; Dang, Xiqiang; Xu, Jiaping; Chen, W.; Yuan, Zhenbing; Mu, Junjian

doi:10.1097/01.hjh.0000539339.99882.e6

Cited by 3 publications

(4 citation statements)

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“…Assembled from April to November 2004, the Baoji Salt-Sensitive Study cohort consists of 514 adults from 124 families in seven villages in Baoji, Shaanxi, China. The detailed design of this study has been published previously (19)(20)(21)(22)(23)(24). To explore the associations of UMOD genetic variations with longitudinal BP changes and hypertension incidence, we followed up this cohort in 2009 and 2012.…”

Section: Incidence Of Hypertensionmentioning

confidence: 99%

“…Total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine, serum uric acid (SUA) and serum glucose levels were analyzed by an automatic biochemical analyzer (Hitachi, Tokyo, Japan) as described previously (23,(32)(33)(34). Serum uromodulin levels were measured by commercially available enzyme-linked immunosorbent assay (ELISA) kits (Cusabio Biotech, Wuhan, China).…”

Section: Blood Biochemical Analysesmentioning

confidence: 99%

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Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Wang

Shi

et al. 2021

Front. Cardiovasc. Med.

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Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk.Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension.Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort.Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension.

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Section: Incidence Of Hypertensionmentioning

confidence: 99%

Section: Blood Biochemical Analysesmentioning

confidence: 99%

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Wang

Shi

et al. 2021

Front. Cardiovasc. Med.

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“…BP was measured by the trained staff using a standard mercury sphygmomanometer as previously described ( 24 , 26 , 27 ). The mean arterial pressure (MAP) was calculated as DBP + [1/3 × (SBP–DBP)].…”

Section: Methodsmentioning

confidence: 99%

“…Triglycerides, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum uric acid, serum Na + and K + , serum phosphate, serum creatinine, blood urea nitrogen, fasting glucose levels, C-reactive protein, glycosylated hemoglobin and urinary albumin-creatinine ratio (uACR) were assessed by an automatic biochemical analyzer (Hitachi, Tokyo, Japan). Details of these assays were described previously ( 24 , 26 , 27 ). Serum renalase levels were measured by using commercially available enzyme-linked immunosorbent assay (ELISA) kits (Cloud-Clone Corp., Houston, TX, USA).…”

Section: Methodsmentioning

confidence: 99%

Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults

Wang

Chen

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveRenalase, a novel secretory flavoprotein with amine oxidase activity, is secreted into the blood by the kidneys and is hypothesized to participate in blood pressure (BP) regulation. We investigated the associations of renalase with BP and the risk of hypertension by examining renalase single nucleopeptide polymorphism (SNPs), serum renalase levels, and renal expression of renalase in humans.Methods① Subjects (n = 514) from the original Baoji Salt-Sensitive Study cohort were genotyped to investigate the association of renalase SNPs with longitudinal BP changes and the risk of hypertension during 14 years of follow-up. ② Two thousand three hundred and ninety two participants from the Hanzhong Adolescent Hypertension Study cohort were used to examine the association of serum renalase levels with hypertension. Renalase expression in renal biopsy specimens from 193 patients were measured by immunohistochemistry. ③ Renalase expression was compared in hypertensive vs. normotensive patients.Results① SNP rs7922058 was associated with 14-year change in systolic BP, and rs10887800, rs796945, rs1935582, rs2296545, and rs2576178 were significantly associated with 14-year change in diastolic BP while rs1935582 and rs2576178 were associated with mean arterial pressure change over 14 years. In addition, SNPs rs796945, rs1935582, and rs2576178 were significantly associated with hypertension incidence. Gene-based analysis found that renalase gene was significantly associated with hypertension incidence over 14-year follow-up after adjustment for multiple measurements. ② Hypertensive subjects had higher serum renalase levels than normotensive subjects (27.2 ± 0.4 vs. 25.1 ± 0.2 μg/mL). Serum renalase levels and BPs showed a linear correlation. In addition, serum renalase was significantly associated with the risk of hypertension [OR = 1.018 (1.006–1.030)]. ③ The expression of renalase in human renal biopsy specimens significantly decreased in hypertensive patients compared to non-hypertensive patients (0.030 ± 0.001 vs. 0.038 ± 0.004).ConclusionsThese findings indicate that renalase may play an important role in BP progression and development of hypertension.

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Effect of Salt Intake on Plasma and Urinary Uric Acid Levels in Chinese Adults

Cited by 3 publications

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Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults

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