Effect of saccharin on albino rats’ blood indices and the therapeutic action of vitamins C and E

Abstract

<jats:p> The present work aimed to study some blood indices of rats as affected by saccharin and the therapeutic action of vitamins C and E. The used adult female Rattus norvegicus albino rats in the present study were weighing 100—120 g. Administration of saccharin at a dose of 35 mg kg<jats:sup>—1</jats:sup> body weight (b.wt.) day<jats:sup>—1</jats:sup> for 35 days significantly decreased serum glucose, triglycerides, cholesterol, total protein and albumin values. These decrements were by 20.16%, 22.76%, 44.92%, 20.16% and 40.44%, respectively, compared to control level (p value &lt; 0.01). But it increased levels of kidney function indices. The effect of saccharin was more pronounced on creatinine. Activities of Alanine aminotranferease (ALT), aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) increased significantly following saccharin treatment to rats. Concerning hematoligical parameters, the more obvious changes were observed in the increment of white blood cell (WBC), mean corpuscular volume (MCV) and platelets (PLT) and the decrease in hematocrit, hemoglobin (Hb) and red blood cells (RBCs) count in response to the administration of saccharin. In general, vitamin C or E (150 mg kg<jats:sup>—1</jats:sup> b.wt. day<jats:sup>—1</jats:sup> for 35 days) was able to reduce the effects of saccharin intake. Both vitamins, however, generally have beneficial effects in reducing the changes in the studied parameters. </jats:p>

Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens

“…Moreover, the present data showed that dietary supplementation with SUC and SAC negatively altered the protein synthesis of broiler chickens. Consistent with our results, daily administration of SAC also decreased serum TP and ALB contents in rats ( Abdelaziz and Ashour, 2011 ). Therefore, our data suggest that dietary STE supplementation could enhance the protein synthesis, whereas SUC and SAC supplementation could reduce it in broiler chickens.…”

Comparative effects of commonly used commercially available non‐nutritive sweeteners on diabetes‐related parameters in non‐diabetic rats

“…Furthermore, 3 weeks supplementation of 0.1% saccharin to juvenile rats did not significantly affect food intake and weight gain (Park et al., 2010). However, female rats fed for 35 days with 35 mg/kg BW of saccharin showed a significant reduction in blood glucose, serum triglycerides and serum cholesterol (Abdelaziz & Ashour, 2011), while normal rats supplemented with 0.0005% saccharin in drinking water showed increased blood glucose and body weight but reduced food intake (Andrejić et al., 2013).…”

Effects of electromagnetic field radiation on biochemical parameters in swiss albino mice

“…In this regard, some investigations reveal that mobile phone electromagnetic waves can affect on different biologic organs like liver [GHAEDI, et al, 2013] , Thyroid glands [MORTAZAVI et al, 2009] and reproductive organs [WEISBORT et al, 2003] and some studies investigated different therapeutic actions reducing the potential effect of electromagnetic waves on biosystems [ABDEL-AZIZ et al, 2010] .…”