Effect of Rutin on Increased Capillary Fragility in Man.

Abstract

animals to maintain a normal acid-base equilibrium of the blood and to eliminate phenolsulphanephthalein.Structural modification associated with the ageing process which may or may not be designated disease, has resulted in the stabilization of a fundamental equilibrium of the animal organism as the animal relates itself to its normal environment and to an abnormal environment brought about by the introduction of a chemical body foreign to its tissues.Summary. Twenty-three senile dogs showing varying degrees of glomerular in jury and at the same time a fairly diffuse change in the type of epithelium in the proximal segment of the renal nephron from a normal order of cuboidal cell to one of a flattened, less spe-cialized type of cell when subjected to the anesthetic action of chloroform for 45 minutes fail to show, as the result of the use of this body, a reduction in the elimination of phenolsulphanephthalein, or a reduction in the reserve alkali of the blood from that value which these animals have established as their pathological normal. In a group of 29 control senile animals, with a normal urine, both chemically and microscopically, with the same order of change in the glomeruli but with, in general, a normal order of cytological structure in the proximal segment of the renal nephron when anesthetized for 45 minutes with chloroform show a marked decrease in the elimination of phenolsulphanephthalein and a reduction in the reserve alkali of the blood.

Studies on Gangrene Following Cold Injury. Ix. The Effect of Rutin and Other Chemical Agents on the Course of Experimental Frostbite in Rabbits 12

“…One of these substances, rutin, has become available recently in pure form. It has been reported to be effective in the treatment of capillary bleeding associated with hypertension in man (13,14), and a recent report (15) indicates that it decreases the incidence of widespread petechiae and ecchymoses in dogs following X-irradiation. Because capillary injury is such a prominent feature in the lesions produced by exposure to severe cold, the effect of rutin was studied on standardized frostbite in rabbits in order to determine the possible prophylactic and/or therapeutic usefulness of this agent.…”

Evaluation of the Mutagenicity Potential of Trace-Rutinosidase Variety of Tartary Buckwheat (<i>Fagopyrum tataricum</i> Gaertn.) Using the Ames Test

“…Rutin is reported to have various effects such as strengthening the blood capillaries [5] [6], as an antioxidant [7]- [9] and to have alpha-glucosidase inhibitory activities [10]. In addition, the clinical effects of rutin in a double-blind crossover study are investigated and reductions in serum myeloperoxidase and cholesterol levels [11], mucosal symptoms, headache, and tiredness are observed [12].…”

Acute and Subacute Toxicity Studies on Rutin-Rich Tartary Buckwheat Dough in Experimental Animals

“…Some reports have shown that rutin strengthens fragile blood capillaries (5,6), and has antioxidative (7,8), antihypertensive (9) and a-glucosidase inhibitory activities (10). The clinical effects of rutin-rich food have also been reported; administration leads to reductions in serum myeloperoxidase and cholesterol levels (11), mucosal symptoms, headache and tiredness (11).…”