Effect of riboflavine deficiency on bone marrow function and protein metabolism in baboons. Preliminary report

Foy, Henry; Kondi, Athena; Mbaya, Vertistine

doi:10.1079/bjn19640029

Cited by 53 publications

(16 citation statements)

References 43 publications

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“…In a study of another aspect of possible environmental carcinogens undertaken by Fresh et al (1967) in Taiwan, samples of air, water, house dust, fuel and ash were collected in the homes of 83 patients with nasopharyngeal carcinoma. Samples of hair and finger-nails were obtained and examined from patients and their families.…”

Section: Trace Elementsmentioning

confidence: 99%

On the epidemiology of nasopharyngeal carcinoma

Clifford

1970

Intl Journal of Cancer

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The incidence of nasopharyngeal carcinoma is high in Chinese in South East China and in those living in a traditional Chinese manner in the countries of South East Asia. The related Mongoloid peoples of Japan and Korea have a low incidence, as do the Caucasians of Europe, America and India. In Chinese born abroad and living in a “Western”‐type environment in Australia, Hawaii and California the incidence falls significantly. This suggests that the high incidence in the Chinese relates to a genetically determined racial or “line” predisposition combined with environmental factors or to environmental factors alone. In Kenya, ethnic origin does not relate to incidence which depends on environmental factors only. The possible significance of genetic factors cannot be assessed until adequate information on the genetic profiles of racial groups with high and low incidences is available. Different environmental factors may be of importance. Biologic agents such as fungi or viruses may be of importance in some areas, in others a physical or chemical agent may be of significance, or the cancer may arise following exposure to a combination of factors. In some areas inhalation of polynuclear hydrocarbons may be of importance, in others the ingestion of nitrosamine‐like compounds, and these external agents may only be effective if combined with a viral infection, possibly the Epstein‐Barr virus or with a particular nutritional or hormonal status. The local tissue sensitivity is the factor which determines the response to any particular external agent. Examination of the external environment is, perhaps, of less importance than that of the milieu intérieur, as it is now recognized that the stability of the respiratory epithelium is affected by hormonal and nutritional factors. Universally the incidence in men is higher than in women, and this may relate to their different internal environments.

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Section: Trace Elementsmentioning

confidence: 99%

On the epidemiology of nasopharyngeal carcinoma

Clifford

1970

Intl Journal of Cancer

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“…Even when carbohydrate was replaced by ethanol to the extent of 50 % of total calories, the remaining carbohydrate was still 11 % of total calories. The mineral composition of the liquid diet is given in table II, and the vitamin content in table III ; both exceeded the require ment for the baboon as formulated by Foy et al [6], Portman [24], and…”

Section: Composition Of the Liquid Diets And Technique Of Pair Feedingmentioning

confidence: 99%

An Experimental Model of Alcohol Feeding and Liver Injury in the Baboon

Lm²

1974

J Med Primatol

219

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A model has been developed for the administration to the baboon of ethanol as part of a nutritionally adequate liquid diet. With this regimen, all animals maintained their weight, and liver morphology was normal in the controls. Isocaloric substitution of carbohydrate (50% of total calories) by ethanol resulted in the production of fatty liver in all animals, while some also developed alcoholic hepatitis and cirrhosis with increased activities of serum glutamic oxaloacetic transaminase. Inebriation and manifestation of dependence upon withdrawal of the diet were observed. Chemical alterations produced by ethanol at the fatty liver stage were characterized by striking triglyceride accumulation and enhanced activities of microsomal enzymes, including the microsomal ethanol oxidizing system (MEOS).

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“…The protein content (18% of total calories) corresponds to that of commonly used commercial diets that are satisfactory for the baboon and is almost twice the amount recommended for human diets (6). The mineral and vitamin content of the diet exceeded the requirements formulated for the monkey (7)(8)(9). Its caloric value was 1 calorie/ml.…”

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confidence: 96%

Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.

Lieber¹,

DeCarli²,

Rubin³

1975

Proc. Natl. Acad. Sci. U.S.A.

165

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This study reproduces in experimental animals the sequential development of all the liver lesions seen in the human alcoholic: in 15 baboons fed ethanol, all developed fatty liver, five progressed to hepatitis, and five had cirrhosis. Maintenance of a nutritionally adequate regimen despite the intake of inebriating amounts of ethanol (50% of total calories) was achieved by incorpora.tion of the ethanol in a totally liquid diet. Upon ethanol withdrawal, signs of physical dependence, such as seizures and tremors, developed. Ultrastructural changes of the mitochondria and the endoplasmic reticulum were already present at the fatty liver stage and persisted throughout the hepatitis and cirrhosis. The lesions were similar to those observed in alcoholics (including the inflammation and the central sclerosis) and differed from the alterations produced by choline and protein deficiencies. At the fatty liver stage, some "adaptive" increases in activity of microsomal enzymes [aniline hydroxylase (EC 1.14.14.1) and the microsomal ethanol oxidizing system] were observed, but these tendedto disappear with the development of hepatitis and cirrhosis. Fat accumulation was also much more pronounced in the animals with the hepatitis as compared with those with simple fatty liver (an 18-fold compared with 3-to 4-fold increase in liver triglycerides). The demonstration that these lesions can develop despite an adequate diet indicates that in addition to correction of the nutritional status, control of alcohol intake is mandatory for the management of patients with alcoholic liver injury.

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Effect of riboflavine deficiency on bone marrow function and protein metabolism in baboons. Preliminary report

Abstract: Reduction in total serum protein content, medullary erythroid hypoplasia, anaemia and abnormal excretion of amino acids and their catabolites are frequent complications of marasmus and kwashiorkor (Foy

Cited by 53 publications

References 43 publications

On the epidemiology of nasopharyngeal carcinoma

On the epidemiology of nasopharyngeal carcinoma

An Experimental Model of Alcohol Feeding and Liver Injury in the Baboon

Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets.

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