Effect of Riboflavin-UVA–Induced Collagen Cross-linking on Intraocular Pressure Measurement

Romppainen, T.; Bachmann, Lucas M.; Kaufmann, C.; Kniestedt, Christoph; Mrochen, Michael; Thiel, Michael

doi:10.1167/iovs.06-1479

Cited by 28 publications

(20 citation statements)

References 18 publications

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“…The significance of the decrease in corneal-compensated IOP without a decrease in Goldmann-correlated IOP is a challenging issue. In an in vitro model of human corneas after CXL, Romppainen et al 19 found that all 3 tested tonometers (Goldmann applanation tonometer, dynamic contour tonometer, Tono-Pen XL) overestimated the true IOP. Wollensak et al 3 report that the IOP measured with a Goldmann tonometer did not change significantly after CXL.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical parameters of the cornea after collagen crosslinking measured by waveform analysis

Sedaghat

Naderi

Zarei-Ghanavati

2010

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 99%

Biomechanical parameters of the cornea after collagen crosslinking measured by waveform analysis

Sedaghat

Naderi

Zarei-Ghanavati

2010

Journal of Cataract and Refractive Surgery

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“…This is attributed to the change in corneal biomechanics, leading to increased corneal rigidity. The difference in IOP measured following CXL ranged from 1.2 to 3.1 mm Hg, depending on the tonometer used [211,212]. …”

Section: Safetymentioning

confidence: 99%

Corneal Collagen Crosslinking: A Systematic Review

Sorkin

Varssano²

2014

Ophthalmologica

160

122

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Keratoconus (KCN) is an ectatic disorder with progressive corneal thinning and a clinical picture of corneal protrusion, progressive irregular astigmatism, corneal fibrosis and visual deterioration. Other ectatic corneal disorders include: post-LASIK ectasia (PLE) and pellucid marginal degeneration (PMD). Corneal crosslinking (CXL) is a procedure whereby riboflavin sensitization with ultraviolet A radiation induces stromal crosslinks. This alters corneal biomechanics, causing an increase in corneal stiffness. In recent years, CXL has been an established treatment for the arrest of KCN, PLE and PMD progression. CXL has also been shown to be effective in the treatment of corneal infections, chemical burns, bullous keratopathy and other forms of corneal edema. This is a current review of CXL - its biomechanical principles, the evolution of CXL protocols in the past, present and future, indications for treatment, treatment efficacy and safety.

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“…Keratokonusta hastalığın ilerlemesine ve korneanın incelmesine paralel olarak 'Goldman applanasyon tonometresi için kornea kalınlığına göre hesap yapan standart nomogramların yaklaşık 2-6 mmHg' GİB 'nı düşük değerlendirdiği bildirilmiştir. 21,22 Dinamik kontür tonometre düzensiz kornealardaki biyomekanik değişikliklerden en az etkilenir. 23,24 Penetran keratoplasti sonrası gelişen ektazi / keratokonus nüksü tedavisinde gözlük ve kontakt lens kullanımından, ikinci penetran keratoplastiye kadar çeşitli yöntemler yer alır.…”

Section: Discussionunclassified

Penetran Keratoplasti Sonrası Ektazi Nüksü

Ayşe¹,

Akkaya²,

Budak³

et al. 2013

Tjo

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Ge lifl Ta ri hi/Re cei ved: 26.04.2012 Ka bul Ta ri hi/Ac cep ted: 04.07.2012 ÖzetPenetran keratoplasti sonrası kornea ektazisi veya keratokonus nüksü nadir görülen bir tablodur ve bu tablo ile ilgili literatürde az sayıda vaka sunuları vardır. Bilgisayarlı topografi kullanımı hastalığın tanı ve tedavisinde oldukça yararlıdır. Tedavide gözlük ve kontakt lens kullanımından, tekrarlanan penetran keratoplastiye kadar birçok yöntem yer alır. Bu makalede penetran keratoplasti sonrası ektazi gelişen iki vakanın klinik ve bilgisayarlı topografi bulguları sunuldu. 45 ve 25 yaşında sağlıklı iki erkek hasta penetran keratoplasti sonrası görme keskinliklerinde azalmadan yakınmaktaydı. Oftalmolojik ve topografi bulguları kornea ektazisi nüksü ile uyumluydu. 45 yaşındaki hasta rekeratoplasti sonrası 0,7 Snellen sırası düzeltilmiş görme keskinliği elde etti. Diğer hastaya kollajen çapraz bağ tedavisi uygulandı, antiglokomatöz tedavi verildi ve görme keskinliği 0,5'e ulaştı. Takip süreleri boyunca ektazide ilerleme olmadı. (Turk J Ophthalmol 2013; 43: 124-8) Anahtar Kelimeler: Penetran keratoplasti, keratokonus, nüks Sum maryCorneal ectasia or recurrent keratoconus after penetrating keratoplasty is rare, and few case reports exist in the literature concerning this condition. Computerized corneal topography is quite useful to identify and manage this disorder. Management consists of several methods ranging from spectacle and contact lens correction to repeated penetrating keratoplasty. Clinical and computerized topography findings of two patients with keratectasia following penetrating keratoplasty are presented in this article. Two healthy 45-year-old and 25-year-old male patients complained of decreased visual acuity following penetrating keratoplasty. Clinical and topographical data were consistent with recurrence of corneal ectasia. After repeated penetrating keratoplasty, best-corrected distance Snellen visual acuity of 0.7 was obtained in the 45-year-old patient. The other patient underwent collagen cross linking, received antiglaucomatous therapy, and his visual acuity reached 0.5. During the follow-up period, ectasia progression did not occur. (Turk J Ophthalmol 2013; 43: 124-8)

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Effect of Riboflavin-UVA–Induced Collagen Cross-linking on Intraocular Pressure Measurement

Abstract: In this in vitro model on human corneas, CCL resulted in an overestimation of true IOP by all the tested tonometers. Although the magnitude of this effect was small, care should be taken when measuring IOP with GAT after CCL, as it results in less accurate, much more variable IOP readings.

Cited by 28 publications

References 18 publications

Biomechanical parameters of the cornea after collagen crosslinking measured by waveform analysis

Biomechanical parameters of the cornea after collagen crosslinking measured by waveform analysis

Corneal Collagen Crosslinking: A Systematic Review

Penetran Keratoplasti Sonrası Ektazi Nüksü

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