Effect of resveratrol on expression of genes involved thermogenesis in mice and humans

Andrade, João Marcus Oliveira; Barcala-Jorge, Antônio Sérgio; Batista-Jorge, Gislaine Cândida; Paraíso, Alanna Fernandes; Freitas, Kátia Michele de; Lelis, Deborah de Farias; Guimarães, André Luiz Sena; Paula, Alfredo Maurício Batista de; Santos, Sérgio Henrique Sousa

doi:10.1016/j.biopha.2019.108634

Cited by 47 publications

(28 citation statements)

References 47 publications

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“…Moreover, the upregulation of SIRT1 by RSV results also in the repression of NF-κB pro-inflammatory responses in adipocytes and macrophages that infiltrate adipose tissue, leading to an improvement in insulin signaling and insulin resistance, as it was shown in genetically obese db/db mice [ 73 ]. Interestingly, a four-week treatment with 500 mg of trans-resveratrol led to the upregulation of thermogenesis-related genes, also in human WAT [ 74 ]. This finding can be partially responsible for the beneficial influence of RSV and its derivates on weight management observed in clinical trials [ 75 ].…”

Section: Non-pharmacological Interventions Aiming At White Adiposementioning

confidence: 99%

Induction of Adipose Tissue Browning as a Strategy to Combat Obesity

Kuryłowicz

Puzianowska-Kuźnicka

2020

IJMS

142

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The ongoing obesity pandemic generates a constant need to develop new therapeutic strategies to restore the energy balance. Therefore, the concept of activating brown adipose tissue (BAT) in order to increase energy expenditure has been revived. In mammals, two developmentally distinct types of brown adipocytes exist; the classical or constitutive BAT that arises during embryogenesis, and the beige adipose tissue that is recruited postnatally within white adipose tissue (WAT) in the process called browning. Research of recent years has significantly increased our understanding of the mechanisms involved in BAT activation and WAT browning. They also allowed for the identification of critical molecules and critical steps of both processes and, therefore, many new therapeutic targets. Several non-pharmacological approaches, as well as chemical compounds aiming at the induction of WAT browning and BAT activation, have been tested in vitro as well as in animal models of genetically determined and/or diet-induced obesity. The therapeutic potential of some of these strategies has also been tested in humans. In this review, we summarize present concepts regarding potential therapeutic targets in the process of BAT activation and WAT browning and available strategies aiming at them.

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Section: Non-pharmacological Interventions Aiming At White Adiposementioning

confidence: 99%

Induction of Adipose Tissue Browning as a Strategy to Combat Obesity

Kuryłowicz

Puzianowska-Kuźnicka

2020

IJMS

142

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“…As commented above, another important protein in thermogenesis is irisin, which increases the expression of browning markers. In this context, it has also been reported in primary subcutaneous adipocytes from humans that FNDC5, the peptide that releases irisin after proteolysis, is highly increased after resveratrol supplementation [174]. However, the in vitro treatment of C2C12 derived myotubes with resveratrol did not increased FNDC5 expression [175].…”

Section: Resveratrolmentioning

confidence: 88%

Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders

Reguero

Cedrón

Wagner

et al. 2021

Cancers

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Obesity is associated to increased incidence and poorer prognosis in multiple cancers, contributing to up to 20% of cancer related deaths. These associations are mainly driven by metabolic and inflammatory changes in the adipose tissue during obesity, which disrupt the physiologic metabolic homeostasis. The association between obesity and hypercholesterolemia, hypertension, cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) is well known. Importantly, the retrospective analysis of more than 1000 epidemiological studies have also shown the positive correlation between the excess of fatness with the risk of cancer. In addition, more important than weight, it is the dysfunctional adipose tissue the main driver of insulin resistance, metabolic syndrome and all cause of mortality and cancer deaths, which also explains why normal weight individuals may behave as “metabolically unhealthy obese” individuals. Adipocytes also have direct effects on tumor cells through paracrine signaling. Downregulation of adiponectin and upregulation of leptin in serum correlate with markers of chronic inflammation, and crown like structures (CLS) associated to the adipose tissue disfunction. Nevertheless, obesity is a preventable risk factor in cancer. Lifestyle interventions might contribute to reduce the adverse effects of obesity. Thus, Mediterranean diet interventional studies have been shown to reduce to circulation inflammatory factors, insulin sensitivity and cardiovascular function, with durable responses of up to 2 years in obese patients. Mediterranean diet supplemented with extra-virgin olive oil reduced the incidence of breast cancer compared with a control diet. Physical activity is another important lifestyle factor which may also contribute to reduced systemic biomarkers of metabolic syndrome associated to obesity. In this scenario, precision nutrition may provide complementary approaches to target the metabolic inflammation associated to “unhealthy obesity”. Herein, we first describe the different types of adipose tissue -thermogenic active brown adipose tissue (BAT) versus the energy storing white adipose tissue (WAT). We then move on precision nutrition based strategies, by mean of natural extracts derived from plants and/or diet derived ingredients, which may be useful to normalize the metabolic inflammation associated to “unhealthy obesity”. More specifically, we focus on two axis: (1) the activation of thermogenesis in BAT and browning of WAT; (2) and the potential of augmenting the oxidative capacity of muscles to dissipate energy. These strategies may be particularly relevant as complementary approaches to alleviate obesity associated effects on chronic inflammation, immunosuppression, angiogenesis and chemotherapy resistance in cancer. Finally, we summarize main studies where plant derived extracts, mainly, polyphenols and flavonoids, have been applied to increase the energy expenditure.

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“…Adipose tissue remodeling represents a further common action between RSV and CR. RSV-treated obese rats or mice are characterized by a significant reduced adipose tissue mass and an increased thermogenesis associated with high expression of SIRT1 and UCP1 [136]. In addition, mice fed a high-fat diet with 0.1% RSV have shown a significant increase of AMPK activation and an upregulation of brown adipocyte markers, including UCP1 [137].…”

Section: From Caloric Restriction To Cr-related Nutrients: Resveratrolmentioning

confidence: 99%

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Senesi

Ferrulli

Luzi

et al. 2021

IJMS

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Type 2 diabetes (T2DM) and cardiovascular disease (CVD) are closely associated and represent a key public health problem worldwide. An excess of adipose tissue, NAFLD, and gut dysbiosis establish a vicious circle that leads to chronic inflammation and oxidative stress. Caloric restriction (CR) is the most promising nutritional approach capable of improving cardiometabolic health. However, adherence to CR represents a barrier to patients and is the primary cause of therapeutic failure. To overcome this problem, many different nutraceutical strategies have been designed. Based on several data that have shown that CR action is mediated by AMPK/SIRT1 activation, several nutraceutical compounds capable of activating AMPK/SIRT1 signaling have been identified. In this review, we summarize recent data on the possible role of berberine, resveratrol, quercetin, and L-carnitine as CR-related nutrients. Additionally, we discuss the limitations related to the use of these nutrients in the management of T2DM and CVD.

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Effect of resveratrol on expression of genes involved thermogenesis in mice and humans

Cited by 47 publications

References 47 publications

Induction of Adipose Tissue Browning as a Strategy to Combat Obesity

Induction of Adipose Tissue Browning as a Strategy to Combat Obesity

Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

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