Effect of resveratrol and in combination with 5-FU on murine liver cancer

Wu, Shengli; Sun, Zheng; Yu, Liang; Meng, Kewei; Qin, Xinglei; Pan, Cheng-En

doi:10.3748/wjg.v10.i20.3048

Cited by 107 publications

(65 citation statements)

References 23 publications

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“…In support of our current finding, one previous in vivo study in mice has shown that RSV could enhance the anti-tumor effect of 5-FU on liver cancer. 11 The available evidence thus supports the use of RSV in the enhancement of 5-FU-induced apoptosis in colon cancer cells, including in cases of p53 loss-related resistance to 5-FU.…”

Section: Discussionmentioning

confidence: 65%

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Chan

Phoo²,

Clément³

et al. 2008

Cancer Biology & Therapy

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Section: Discussionmentioning

confidence: 65%

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Chan

Phoo²,

Clément³

et al. 2008

Cancer Biology & Therapy

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“…To overcome drug resistance in tumor cells, several studies have examined novel treatments or combination therapies with 5-FU. Previous studies have demonstrated that co-treatment with genistein and 5-FU induces apoptosis more efficiently compared with either drug alone in colon cancer and co-treatment with 5-FU and resveratrol is more efficient compared with controls in suppressing tumor cell growth in a murine model of liver cancer (4,10).…”

Section: Introductionmentioning

confidence: 99%

Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells

Lee

Koo

Park

et al. 2015

Molecular Medicine Reports

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Abstract. 5-Fluorouracil (5-FU) has been used as a chemotherapeutic drug for various types of cancer, although the development of resistance remains a major limitation for its use in clinical settings. In the present study, the anti-angiogenic effects of resveratrol and 5-FU either alone or in combination were examined in a B16 murine melanoma model. Co-treatment using resveratrol and 5-FU inhibited cell proliferation more efficiently compared with use of either drug alone and the antiproliferative effect coincided with changes in the expression levels of AMP-activated protein kinase (AMPK), cyclooxygenase-2, vasodilator-stimulated phosphoprotein (VASP) and vascular endothelial growth factor (VEGF). Furthermore, co-treatment with resveratrol and 5-FU reduced tumor growth compared with that in the control group and this growth-inhibitory effect was associated with changes in the expression levels of AMPK, VASP and VEGF. Immunohistochemical staining for angiogenesis demonstrated that co-treatment with resveratrol and 5-FU reduced the number of microvascular vessels compared with that in the control group. These results suggested that co-treatment with resveratrol and 5-FU suppressed cell growth and angiogenesis in B16 murine melanoma tumors.

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“…Flow cytometry also suggested a synergistic effect on apoptosis of liver cancer cells. The application of 5-FU is restrained in clinical practice for the sake of side effects (Wu et al, 2004, Yang et al, 2005. C-myc ASODN can increase the sensitivity of liver cancer cells to 5-FU, reducing the dosage of 5-FU and toxic side effects and increasing effects.…”

Section: Discussionmentioning

confidence: 99%

Liposome-mediated Induction of Apoptosis of Human Hepatoma Cells by C-Myc Antisense Phosphorothioate Oligodeoxynucleotide and 5-Fluorouracil

Yuan

Cai²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Effect of resveratrol and in combination with 5-FU on murine liver cancer

Cited by 107 publications

References 23 publications

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53

Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells

Liposome-mediated Induction of Apoptosis of Human Hepatoma Cells by C-Myc Antisense Phosphorothioate Oligodeoxynucleotide and 5-Fluorouracil

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