Effect of resorption rate and osteoconductivity of biodegradable calcium phosphate materials on the acquisition of natural bone strength in the repaired bone

Abstract

The purpose of this study was to compare the biodegradation rate and quality of regenerated bone among four materials. A short time period of 8 weeks was chosen to examine early bone healing. The rod-shaped implants of commercially available two β-tricalcium phosphate (β-TCP) ceramics with porosity 60% and 71-80%, respectively, laboratory prepared octacalcium phosphate/gelatin composite (OCP/Gel), which has been proven to have a highly osteoconductive and biodegradable property in rat calvarial defect, and gelatin sponge (Gelatin) were implanted in rabbit tibia defect of 6 mm diameter and 7 mm depth for 2, 4 and 8 weeks. Analyses by μCT, histomorphometry and push-in test were carried out to evaluate the extent of the tissue regeneration and the material biodegradation in the long bone. OCP/Gel and Gelatin were completely resorbed but only OCP/Gel induced cortical bone bridge until 8 weeks that has strength compatible to that of the natural bone. β-TCP (71%-80%) and β-TCP (60%) were not completely resorbed and never induced the amount of new bone formation beyond that by OCP/Gel. The results indicate that the new bone having enough strength could be regenerated if the material shows not only higher biodegradation rate but also higher osteoconductivity. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2833-2842, 2016.

Octacalcium phosphate bone substitute materials: Comparison between properties of biomaterials and other calcium phosphate materials

“…A higher osteoconductivity was first observed in the bone tissue response of mouse cortical bone where OCP was placed onto the calvaria in its granule form, as compared to other Ca-P materials, including the anhydrous form of dicalcium phosphate (DCP), amorphous calcium phosphate (ACP), calcium-deficient HA (CDHA), and stoichiometric HA (both HAs were prepared without sintering) 6) . Our subsequent studies further provided evidence that OCP tends to biodegrade in the implanted sites in the bone [15][16][17][18][19][20][21][22][23][24][25][26] .…”

“…We have succeeded in developing a composite scaffold with OCP and gelatin 21,22,36) . Gelatin consists of biodegradable polymers denatured from collagen.…”

Fabrication of calcium phosphate 3D scaffolds for bone repair using magnetic levitational assembly

“…The main goal of the present study was to prove the possibility of using the formative approach based on magnetic levitation assembly of the α-TCP particles with subsequent recrystallization into OCP considered as most favorable type of CP for bone remodeling to form 3D scaffold for bone tissue engineering 24,25 . The technology of magnetic levitation has been demonstrated previously in the number of innovative studies 18,22 .…”

Biological properties of calcium phosphate biomaterials for bone repair: a review

“…Recently, calcium phosphate materials have been gradually attracting signicant attention due to their excellent abilities to induce osteoblast differentiation into bone cells, 8,9 causing them to grow on the surface of scaffolds 10,11 and degrade at proper rates, 12,13 and even be totally replaced by newly formed bone tissue, in addition to withstanding stress at the defect site. 14 Within the calcium phosphate family, HA (hydroxyapatite) has been widely studied since the 1980s, 15 and its inorganic composition is similar to that of natural bone.…”