Fabrication of calcium phosphate 3D scaffolds for bone repair using magnetic levitational assembly

Parfenov, Vladislav A.; Mironov, Vladimir; Koudan, Elizaveta V.; Nezhurina, Elizaveta K.; Каралкин, П. А.; Pereira, Frederico D. A. S.; Petrov, Stanislav V.; Krokhmal, A. A.; Aydemir, Timur; Вахрушев, И. В.; Zobkov, Yu. V.; Smirnov, Igor; Fedotov, A. Yu.; Demirci, Utkan; Khesuani, Yusef D.; Komlev, V. S.

doi:10.1038/s41598-020-61066-3

Cited by 22 publications

(22 citation statements)

References 29 publications

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“…mT, which can promote the proliferation and differentiation of osteoblasts (Parfenov et al, 2020). Fernandes discovered that magnetic fields can promote gene expression in mouse neural stem cells (Fernandes et al, 2019).…”

Section: Magnetic Nanoparticles Combined With Magnetic Field Stimulationmentioning

confidence: 99%

“…The magnetic nanoparticles have the ability to bind to the cell surface, which makes it possible to control and regulate the function of cells under the condition of an external magnetic field (Hurle et al, 2018 ; Fernandes et al, 2019 ; Parfenov et al, 2020 ). Qian et al studied the effect of magnetic nanoparticles on bone marrow mesenchymal stem cells (Qian et al, 2018 ).…”

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

“…Under the action of an external magnetic field, osteoblasts will show a positive effect on the proliferation and differentiation. Both the magnetic particles and the applied magnetic field have a synergistic effect on the cells (Parfenov et al, 2020 ) ( Figure 4 ).…”

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

“…Fabrication of calcium phosphate 3D scaffolds for bone repair using magnetic stimulation. Reproduced with permission from (Parfenov et al, 2020 ).…”

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

“…By using chemical co-precipitation method, MNPs were evenly dispersed into PVA nanofibers, and then made into a film by in-situ generation and an electrospinning method to obtain PVA nanofiber membranes containing MNPs with good dispersion (Manjua et al, 2019 ). Parfenov et al grew osteoblasts on the surface of polystyrene, and applied a static magnetic field of 150 mT, which can promote the proliferation and differentiation of osteoblasts (Parfenov et al, 2020 ). Fernandes discovered that magnetic fields can promote gene expression in mouse neural stem cells (Fernandes et al, 2019 ).…”

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

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Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

et al. 2020

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The magnetic field has been proven to enhance bone tissue repair by affecting cell metabolic behavior. Magnetic nanoparticles are used as biomaterials due to their unique magnetic properties and good biocompatibility. Through endocytosis, entering the cell makes it easier to affect the physiological function of the cell. Once the magnetic particles are exposed to an external magnetic field, they will be rapidly magnetized. The magnetic particles and the magnetic field work together to enhance the effectiveness of their bone tissue repair treatment. This article reviews the common synthesis methods, the mechanism, and application of magnetic nanomaterials in the field of bone tissue repair.

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Section: Magnetic Nanoparticles Combined With Magnetic Field Stimulationmentioning

confidence: 99%

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

“…Fabrication of calcium phosphate 3D scaffolds for bone repair using magnetic stimulation. Reproduced with permission from (Parfenov et al, 2020 ).…”

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

Section: Preparation Of Magnetic Nanomaterialsmentioning

confidence: 99%

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Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

et al. 2020

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Reversible Design of Dynamic Assemblies at Small Scales

Soto

Wang

Deshmukh

et al. 2020

Advanced Intelligent Systems

Self Cite

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Emerging bottom-up fabrication methods have enabled the assembly of synthetic colloids, microrobots, living cells, and organoids to create intricate structures with unique properties that transcend their individual components. Herein, an access point to the latest developments is provided in externally driven assembly of synthetic and biological components. In particular, reversibility is emphasized, which enables the fabrication of multiscale systems that would not be possible under traditional techniques. Magnetic, acoustic, optical, and electric fields are the most promising methods for controlling the reversible assembly of biological and synthetic subunits as they can reprogram their assembly by switching on/off the external field or shaping these fields. Capabilities are featured to dynamically actuate the assembly configuration by modulating the properties of the external stimuli, including frequency and amplitude. The design principles are designed, which enable the assembly of reconfigurable structures. Finally, the high degree of control capabilities offered by externally driven assembly will enable broad access to increasingly robust design principles toward building advanced dynamic intelligent systems is foreseen.

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Magnetic levitation-based miniaturized technologies for advanced diagnostics

Karakuzu,

Anil İnevi,

Tarim

et al. 2024

emergent mater.

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Taking advantage of the magnetic gradients created using magnetic attraction and repulsion in miniaturized systems, magnetic levitation (MagLev) technology offers a unique capability to levitate, orient and spatially manipulate objects, including biological samples. MagLev systems that depend on the inherent diamagnetic properties of biological samples provide a rapid and label-free operation that can levitate objects based on their density. Density-based cellular and protein analysis based on levitation profiles holds important potential for medical diagnostics, as growing evidence categorizes density as an important variable to distinguish between healthy and disease states. The parallel processing capabilities of MagLev-based diagnostic systems and their integration with automated tools accelerates the collection of biological data. They also offer notable advantages over current diagnostic techniques that require costly and labor-intensive protocols, which may not be accessible in a low-resource setting. MagLev-based diagnostic systems are user-friendly, portable, and affordable, making remote and label-free applications possible. This review describes the recent progress in the application of MagLev principles to existing problems in the field of diagnostics and how they help discover the molecular- and cellular-level changes that accompany the disease or condition of interest. The critical parameters associated with MagLev-based diagnostic systems such as magnetic medium, magnets, sample holders, and imaging systems are discussed. The challenges and barriers that currently limit the clinical implications of MagLev-based diagnostic systems are outlined together with the potential solutions and future directions including the development of compact microfluidic systems and hybrid systems by leveraging the power of deep learning and artificial intelligence.

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Fabrication of calcium phosphate 3D scaffolds for bone repair using magnetic levitational assembly

Cited by 22 publications

References 29 publications

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

Recent Advances of Magnetic Nanomaterials in Bone Tissue Repair

Reversible Design of Dynamic Assemblies at Small Scales

Magnetic levitation-based miniaturized technologies for advanced diagnostics

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