Effect of Resistance Exercise on Muscle Metabolism and Autophagy in sIBM

Jeong, Jong Seob; Yang, Dae-Seung; Koo, Jung-Hoon; Hwang, Dong-Ju; Cho, Joon-Yong; Kang, Eun-Bum

doi:10.1249/mss.0000000000001286

Cited by 15 publications

(24 citation statements)

References 44 publications

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“…We found that CQ treatment significantly increased Aβ accumulation in SM, but not in FHL muscle (data not shown), which is in agreement with our and other previous studies [18, 24]. Importantly, this finding provides further evidence for why muscle atrophy was induced predominantly in SM.…”

Section: Discussionsupporting

confidence: 93%

“…These findings indicated that PINK1/parkin-mediated activation of mitophagy was blocked, which might be associated with CQ-induced Aβ accumulation, as suggested by the negative correlations between Aβ oligomers and mito-PINK1 and mito-parkin. Previous studies have suggested that physical exercise rescued impaired autophagy flux by CQ treatment in the brain and muscle [18, 27, 35], but the relationship between RE and CQ-induced abnormal mitophagy flux had not been demonstrated. Interestingly, RE dramatically reversed the levels of both proteins, thus likely restoring PINK1/parkin-mediated mitophagy initiation.…”

Section: Discussionmentioning

confidence: 99%

“…At 9 weeks after CQ treatment, RE was performed as previously described [18]. For RE, rats climbed up a ladder (width × length × interval, 115 × 20 × 4 cm, 85° incline) twice with a weighted load fixed to their tail.…”

Section: Methodsmentioning

confidence: 99%

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Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body Myositis

2019

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Background: Mitochondrial dysfunction is implicated in the pathogenesis of multiple muscular diseases, including sporadic inclusion body myositis (s-IBM), the most common aging-related muscle disease. However, the factors causing mitochondrial dysfunction in s-IBM are unknown. Objective: We hypothesized that resistance exercise (RE) may alleviate muscle impairment by improving mitochondrial function via reducing amyloid-beta (Aβ) accumulation. Methods: Twenty-four male Wistar rats were randomized to a saline-injection control group (sham, n = 8), a chloroquine (CQ) control group (CQ-CON, n = 8), and a CQ plus RE group (CQ-RE, n = 8) in which rats climbed a ladder with weight attached to their tails 9 weeks after starting CQ treatment. Results: RE markedly inhibited soleus muscle atrophy and muscle damage. RE reduced CQ-induced Aβ accumulation, which resulted in decreased formation of rimmed vacuoles and mitochondrial-mediated apoptosis. Most importantly, the decreased Aβ accumulation improved both mitochondrial quality control (MQC) through increased mitochondrial biogenesis and mitophagy, and mitochondrial dynamics. Furthermore, RE-mediated reduction of Aβ accumulation elevated mitochondrial oxidative capacity by upregulating superoxide dismutase-2, catalase, and citrate synthase via activating sirtuin 3 signaling. Conclusion: RE enhances mitochondrial function by improving MQC and mitochondrial oxidative capacity via reducing Aβ accumulation, thereby inhibiting CQ-induced muscle impairment, in a rat model of s-IBM.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body Myositis

2019

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“…The effects of exercise have been shown to be an autophagic inducer, cellular autophagic responses to exercise in skeletal muscle appear to be varied in different exercise protocols and disease models (Lenhare et al ; Jeong et al ). Exercise is the greatest physiological stress that our bodies experience.…”

Section: Discussionmentioning

confidence: 99%

“…In the recent past (Lee et al 2013), it was demonstrated that exercise preconditioning reduces acute ischemic renal injury in HSP70.1 knockout mouse. The effects of exercise have been shown to be an autophagic inducer, cellular autophagic responses to exercise in skeletal muscle appear to be varied in different exercise protocols and disease models (Lenhare et al 2017;Jeong et al 2017). Exercise is the greatest physiological stress that our bodies experience.…”

Section: Discussionmentioning

confidence: 99%

Preconditioning by aerobic exercise reduces acute ischemic renal injury in rats

et al. 2019

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Acute kidney injury (AKI) can be defined as the sudden loss of renal function associated with structural changes in the kidneys. Currently, 13.3 million people die of AKI around the world. Normally aerobic exercise is used both as/for the treatment and prevention of high blood pressure, metabolic disease and Diabetes mellitus (DM). Nevertheless, exercise preconditioning must be a crucial resource in the prevention and mitigation of AKI. The aim of this study was to evaluate the effects of the exercise preconditioning on renal IR (ischemic/reperfusion) experimental model. Male Wistars rats were divided into three groups ( n = 9): sham (S), ischemic/reperfusion (IR), exercise + ischemic/reperfusion (EX + IR). IR renal injury was induced by clamping the bilateral renal artery for 45 min. The rats were subjected to exercise 5 days a week for 4 weeks with progressive intensity and duration. The group treated with exercise preconditioning, showed additional improvements in various parameters, including serum creatinine, proteinuria, and decrease of the severity of the tubular injury and activated caspase‐3 levels ( P < 0.05). The previous aerobic exercise‐induced renoprotection in the IR injury. We anticipate that the practice of physical exercise in healthy individuals can also be useful for the prevention and attenuation of AKI.

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Liver regeneration after hepatectomy is significantly suppressed in a muscular atrophy mouse model

Hagiwara,

Watanabe,

Harimoto

et al. 2023

J Hepato Biliary Pancreat

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BackgroundSarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. As reported in previous studies, the loss of skeletal muscle mass is associated with poor liver regeneration after hepatectomy. It is considered important to clarify the effect of sarcopenia on liver regeneration; however, there are no reports about model animals for sarcopenia. We focused on the peroxisome proliferator‐activated receptor‐gamma coactivator‐1alpha (PGC‐1α) transgenic mice that overexpressed PGC‐1α, specifically for skeletal muscle, and showed significant atrophy of type 2B fiber‐rich muscles like sarcopenia.MethodsWe performed 70% hepatectomy using PGC‐1α transgenic mice and examined the liver regeneration rate and the effects of branched‐chain amino acids (BCAA) after hepatectomy.ResultsLiver regeneration after 70% hepatectomy was significantly suppressed in the PGC‐1α transgenic mice. In addition, a decrease in the blood BCAA concentration and a decrease in the liver glycogen content after 70% hepatectomy were observed in the PGC‐1α transgenic mice. By administering BCAA before and after surgery, it was clarified that a significant increase in the blood BCAA concentration was observed and the liver regeneration rate was improved in the PGC‐1α transgenic mice.ConclusionsBCAA administration may improve the suppression of liver regeneration in patients with sarcopenia.

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Effect of Resistance Exercise on Muscle Metabolism and Autophagy in sIBM

Cited by 15 publications

References 44 publications

Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body Myositis

Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body Myositis

Preconditioning by aerobic exercise reduces acute ischemic renal injury in rats

Liver regeneration after hepatectomy is significantly suppressed in a muscular atrophy mouse model

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