Effect of Resiniferatoxin as an Anti-Inflammatory Drug  on Experimental Trichinellosis

Balaha, Doaa A.A.; Ismail, Howaida I. H.; Risk, Omnia M. K.; Gamea, Ghada A.

doi:10.20546/ijcmas.2020.907.343

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…Besides, Fahmy and Diab (2021) reported that albenazole treated infected mice showed larval deposition surrounded by mild muscle inflammation. Also, this agreed with Balaha et al (2020) who found that T. spiralis infected mice treated with albendazole gave a reduced amount of encapsulated larvae encircled by a modest infiltration of inflammatory cells.…”

Section: Discussionsupporting

confidence: 91%

“…Besides, it agreed with Salama et al (2022), who found that larvae treated with albendazole and prednisolone showed a mild to moderate inflammatory cellular infiltrate. Again, Balaha et al (2020) found that Albendazole and resiniferatoxintreated mice exhibited a limited quantity of T. spiralis larvae and mild inflammation; some muscles retained normal striation.…”

Section: Discussionmentioning

confidence: 97%

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Study on Therapeutic Efficacy of Lactoferrin Loaded on Silvernanoparticles Against Trichinella Spiralis Parenteral Phase

EL-GHANNAM,

EL HAMSHARY,

ALI

et al. 2024

Journal of the Egyptian Society of Parasitology

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Globally trichinellosis (Trichinella species) is a risky parasitic zoonosis Anthelminthic such as oral albendazole ® and mebendazole ® commonly used to treatment are poorly water soluble with unfavo-rable bioavailability. This study evaluated the therapeutic efficacy of lactoferrin loaded on silver nanoparticles on Trichinella spiralis infection in experimental infected mice by parasitological and histopathological parameters. Mice were classified into 8 groups each of 5 mice. G1: Non infected non treated (normal), G2: Infected non treated (infected control), G3: In-fected and albendazole, treated, G4: Infected and lactoferrin treated, G5: Infected and silver nanoparticles treated, G6: Infected and lactoferrin loaded on silver nanoparticles treated, G7: Infected and albendazole & lactoferrin, & G8: Infected and albendazole combined with lactoferrin loaded on silver nanoparticles treated.The results showed a significant decrease in all treated groups, markedly in T. spiralis larval muscles treated with combination of albendazole and lactoferrin loaded on silver nanoparticles (92.39%), with muscles histopathological changes.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Study on Therapeutic Efficacy of Lactoferrin Loaded on Silvernanoparticles Against Trichinella Spiralis Parenteral Phase

EL-GHANNAM,

EL HAMSHARY,

ALI

et al. 2024

Journal of the Egyptian Society of Parasitology

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“…spiralis infection, since a significant decrease in the number of eosinophils in blood and in the parasite burden of T . spiralis in the muscular tissue was observed (Balaha et al, 2020; Muñoz‐Carrillo et al, 2017c; Muñoz‐Carrillo et al, 2017b). Therefore, these findings are in agreement with the present results, it was observed that treatment with RTX significantly decreased (* p < .05) plasma levels of PGE 2 and TNF‐α, at 14 and 18 hours after pulp damage.…”

Section: Discussionmentioning

confidence: 99%

Effect of treatment with resiniferatoxin in an experimental model of pulpal inflammatory in mice

et al. 2021

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Aim To evaluate whether treatment with resiniferatoxin (RTX) is capable of lowering the plasma levels of PGE2 and TNF‐α, as well as histopathological parameters in inflammation of pulp tissue in a mouse experimental model. Methodology Ten groups of six BALB/c mice were formed as follows: healthy group (HC), healthy group treated with RTX (HRTX), two groups with pulp inflammation at 14 and 18 hours (PI14/PI18), six groups with pulpal inflammation plus treatment with Ibuprofen (IBU14/IBU18), dexamethasone (DEX14/DEX18) and resiniferatoxin (RTX14/RTX18) at 14 and 18 hours, respectively. Pulpal inflammation was induced through occlusal exposure of the pulp of the maxillary first molar. The plasma levels of PGE2 and TNF‐α and the histological parameters of the pulp tissue of the HC and HRTX groups were evaluated at the time of acquiring the animals. In the other groups, the plasma levels of PGE2 and TNF‐α and the histopathological parameters were evaluated at 14 and 18 hours after pulp damage. Plasma levels of PGE2 and TNF‐α were quantified by ELISA, and the histopathological parameters were evaluated by H/E staining. Statistical significance was determined by one‐way analysis of variance (ANOVA) to test for overall differences between group means. Results A significant increase (*p < .05) in plasma levels of PGE2 and TNF‐α occurred 14 and 18 hours after pulp damage. In addition, treatment with RTX significantly decreased (*p < .05) the plasma levels of PGE2 and TNF‐α at 14 and 18 hours after pulp damage, as well as the infiltrate of inflammatory cells at 18 hours after pulp damage, similarly to treatment with ibuprofen and dexamethasone. Conclusion It was possible to detect systemic levels of PGE2 and TNF‐α at 14 and 18 hours after pulp damage. Likewise, treatment with RTX was associated with an anti‐inflammatory effect similar to treatment with ibuprofen and dexamethasone. These findings place resiniferatoxin as a therapeutic alternative in the treatment of inflammatory diseases in Dentistry.

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Effect of Resiniferatoxin as an Anti-Inflammatory Drug on Experimental Trichinellosis

Cited by 2 publications

References 18 publications

Study on Therapeutic Efficacy of Lactoferrin Loaded on Silvernanoparticles Against Trichinella Spiralis Parenteral Phase

Study on Therapeutic Efficacy of Lactoferrin Loaded on Silvernanoparticles Against Trichinella Spiralis Parenteral Phase

Effect of treatment with resiniferatoxin in an experimental model of pulpal inflammatory in mice

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