Study on Therapeutic Efficacy of Lactoferrin Loaded on Silvernanoparticles Against Trichinella Spiralis Parenteral Phase

Abstract

Globally trichinellosis (Trichinella species) is a risky parasitic zoonosis Anthelminthic such as oral albendazole ® and mebendazole ® commonly used to treatment are poorly water soluble with unfavo-rable bioavailability. This study evaluated the therapeutic efficacy of lactoferrin loaded on silver nanoparticles on Trichinella spiralis infection in experimental infected mice by parasitological and histopathological parameters. Mice were classified into 8 groups each of 5 mice. G1: Non infected non treated (normal), G2: Infected non treated (infected control), G3: In-fected and albendazole, treated, G4: Infected and lactoferrin treated, G5: Infected and silver nanoparticles treated, G6: Infected and lactoferrin loaded on silver nanoparticles treated, G7: Infected and albendazole & lactoferrin, & G8: Infected and albendazole combined with lactoferrin loaded on silver nanoparticles treated.The results showed a significant decrease in all treated groups, markedly in T. spiralis larval muscles treated with combination of albendazole and lactoferrin loaded on silver nanoparticles (92.39%), with muscles histopathological changes.