Effect of Reserpine on the Intracellular Distribution of Catecholamines in the Brain Stem of the Rabbit

Weil‐Malherbe, H.; Bone, A. D.

doi:10.1038/1811474a0

Cited by 27 publications

(9 citation statements)

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“…This difference with the (dt) rat can not be explained by the age of the animals at which reserpine was injected, since the level of maturation of NA storage mechanisms is the same at 20 and 90 d (Kulkarni and Shideman, 1966). Our results suggest that the higher levels of NA in CE after X-irradiation are localized in a reserpinesensitive granular pool, since this drug blocks the ability of amine granules to store the transmitter (Weil-Malherbe and Bone, 1959). This granular pool contains NA that comes mainly from synthesis (Bennett, 1973;Basbaum and Heuser, 1979), suggesting a link between the depleting effect of reserpine, and the increase in the total activity of TH reported here.…”

Section: Discussionsupporting

confidence: 56%

Increased activity of tyrosine hydroxylase in the cerebellum of the X-irradiated dystonic rat

Dopico

Rı́os

et al. 1990

Molecular and Chemical Neuropathology

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The exposure of the cephalic end of rats to repeated doses of X-irradiation (150 rad) immediately after birth induces a long-term increase in the noradrenaline (NA) content of cerebellum (CE) (+ 37.8%), and a decrease in cerebellar weight (65.2% of controls), which results in an increased NA concentration (+ 109%). This increase in the neurotransmitter level is accompanied by a dystonic syndrome and histological abnormalities: Purkinje cells (the target cells for NA afferents to CE) fail to arrange in a characteristic monolayer, and their primary dendritic tree appears randomly oriented. The injection of reserpine 0.9 and 1.2 mg/kg ip to adult rats for 18 h depletes cerebellar NA content in both controls (15.7 +/- 4 ng/CE and 2.8 +/- 1.5 ng/CE, respectively) and X-irradiated rats (17.1 +/- 1 ng/CE and 8.3 +/- 2 ng/CE, respectively). The activity of tyrosine hydroxylase (TH) in CE of adult rats, measured by an in vitro assay, is significantly increased in neonatally X-irradiated animals when compared to age-matched controls (16.4 +/- 1.4 vs 6.32 +/- 0.6 nmol CO2/h/mg prot., p less than 0.01). As observed for NA levels, a net increase in TH activity induced by the ionizing radiation is also measured: 308.9 +/- 23.8 vs 408.2 +/- 21.5 nmol CO2/h/CE, p less than 0.01 (controls and X-treated, respectively). These results suggest that X-irradiation at birth may induce an abnormal sprouting of noradrenergic afferents to CE. The possibility that these changes represent a response of the NA system to the dystonic syndrome is discussed.

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Section: Discussionsupporting

confidence: 56%

Increased activity of tyrosine hydroxylase in the cerebellum of the X-irradiated dystonic rat

Dopico

Rı́os

et al. 1990

Molecular and Chemical Neuropathology

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“…The sedation caused by reserpine, accompanying a decrease in the content of catecholamine in brain, is restored by administration of dopa (1)(2)(3)(4). These results suggest that dopa is a precursor of catecholamine in brain and taken up into brain tissue from circulation system, through blood brain barrier and cell membrane, though catecholamine is considered to be difficult to permeate the blood brain barrier.…”

Section: Epartment Of Pharmacology Faculty Of Medicine Osaka Uniomentioning

confidence: 99%

Studies on Active Trasport of L-Dopa (Dihydroxy-Phenylalanine) Into Brain Slices

Yoshida

Namba

Kaniike

et al. 1963

Japanese Journal of Pharmacology

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“…The similar sequence might be expected in the animal which received PIH in this experiment. Although there are reports (21,22) which concerned the ratio of bound noradrenaline/free noradrenaline of the brain in response to iproniazid injection, reliable results were not yet obtained. There is no evidence to sup port that neither the relative amounts of serotonin and noradrenaline nor the ratio of bound/free of both amines are essential for the activity of the EEG pattern.…”

Section: Discussionmentioning

confidence: 99%

ELECTROENCEPHALOGRAPHIC STUDIES ON THE ACTION OF RESERPINE, 3, 4-DIHYDROXYPHENYLALANINE AND 5-HYDROXYTRYPTOPHANE IN REFERENCE TO THE EFFECTS OF PRETREATMENT WITH BETA-PHENYLiSOPROPYLHYDRAZINE

Kikuchi

1962

Japanese Journal of Pharmacology

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The release and the depletion of noradrenaline (1) and serotonin (2) in the central nervous system by the administration of reserpine have been already confirmed by many investigators. showed that the sedative effect of reserpine derived from the release and the depletion of serotonin in the central nervous system. Subsequently, they discussed the role of the serotonergic or Hess' trophotropic system on the activity of the central nervous system. Carlsson (7,8), on the contrary, discussed the role of nor adrenaline on the activity of the system from the antagonistic action of 3,4-dihydroxy phenylalanine (DOPA), the precursor of noradrenaline, on the sedative effect of reserpine in mice. In his experiment the administration of 5-hydroxytryptophane, the precursor of serotonin, to the sedated animal induced by reserpine did not reveal the similar anta gonistic effect. Electroencephalographically studying the effects of reserpine, serotonin, 5-hydroxytryptophane and DOPA in rabbit, Monnier and Tissot (9) concluded that seroto nin and 5-hydroxytryptophane stimulated the intralaminal thalamic system and depressed the reticular ascending system, while noradrenaline and DOPA showed an opposite effect. Costa et al. (10) studied the normal content of serotonin and noradrenaline in rabbit's brain in relation to the encephalographic pattern of the animal. They concluded that 5-hydroxytryptophane affected EEG by direct action on the mesodiencephalic reticular formation, and that the amounts of serotonin and noradrenaline as well as the rate of synthesis of the amines in the brain after the injection of monoamine oxidase inhibitors were the determining factors for the pattern of EEG.The effect of reserpine on EEG of an intact rabbit was studied in combination with the administration of methamphetamine in the previous paper (11). In this report the effects of beta-phenylisopropylhydrazine, DOPA, 5-hydroxytryptophane and reserpine on the electroencephalographic activity of the neocortex, the limbic system and the reticular activating system including the thalamocortical system were studied in rabbit. METHODSUnanesthetized rabbit, weighing 2 to 3 kg, was used for the experiment. The head of the animal was fixed on the stereotaxic instrument (Todai Noken type). Under ether

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Effect of Reserpine on the Intracellular Distribution of Catecholamines in the Brain Stem of the Rabbit

Cited by 27 publications

References 1 publication

Increased activity of tyrosine hydroxylase in the cerebellum of the X-irradiated dystonic rat

Increased activity of tyrosine hydroxylase in the cerebellum of the X-irradiated dystonic rat

Studies on Active Trasport of L-Dopa (Dihydroxy-Phenylalanine) Into Brain Slices

ELECTROENCEPHALOGRAPHIC STUDIES ON THE ACTION OF RESERPINE, 3, 4-DIHYDROXYPHENYLALANINE AND 5-HYDROXYTRYPTOPHANE IN REFERENCE TO THE EFFECTS OF PRETREATMENT WITH BETA-PHENYLiSOPROPYLHYDRAZINE

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