ELECTROENCEPHALOGRAPHIC STUDIES ON THE ACTION OF RESERPINE, 3, 4-DIHYDROXYPHENYLALANINE AND 5-HYDROXYTRYPTOPHANE IN REFERENCE TO THE EFFECTS OF PRETREATMENT WITH BETA-PHENYLiSOPROPYLHYDRAZINE

Abstract

The release and the depletion of noradrenaline (1) and serotonin (2) in the central nervous system by the administration of reserpine have been already confirmed by many investigators. showed that the sedative effect of reserpine derived from the release and the depletion of serotonin in the central nervous system. Subsequently, they discussed the role of the serotonergic or Hess' trophotropic system on the activity of the central nervous system. Carlsson (7,8), on the contrary, discussed the role of nor adrenaline on the activity of the system from the antagonistic action of 3,4-dihydroxy phenylalanine (DOPA), the precursor of noradrenaline, on the sedative effect of reserpine in mice. In his experiment the administration of 5-hydroxytryptophane, the precursor of serotonin, to the sedated animal induced by reserpine did not reveal the similar anta gonistic effect. Electroencephalographically studying the effects of reserpine, serotonin, 5-hydroxytryptophane and DOPA in rabbit, Monnier and Tissot (9) concluded that seroto nin and 5-hydroxytryptophane stimulated the intralaminal thalamic system and depressed the reticular ascending system, while noradrenaline and DOPA showed an opposite effect. Costa et al. (10) studied the normal content of serotonin and noradrenaline in rabbit's brain in relation to the encephalographic pattern of the animal. They concluded that 5-hydroxytryptophane affected EEG by direct action on the mesodiencephalic reticular formation, and that the amounts of serotonin and noradrenaline as well as the rate of synthesis of the amines in the brain after the injection of monoamine oxidase inhibitors were the determining factors for the pattern of EEG.The effect of reserpine on EEG of an intact rabbit was studied in combination with the administration of methamphetamine in the previous paper (11). In this report the effects of beta-phenylisopropylhydrazine, DOPA, 5-hydroxytryptophane and reserpine on the electroencephalographic activity of the neocortex, the limbic system and the reticular activating system including the thalamocortical system were studied in rabbit. METHODSUnanesthetized rabbit, weighing 2 to 3 kg, was used for the experiment. The head of the animal was fixed on the stereotaxic instrument (Todai Noken type). Under ether

Effect of Tetrabenazine on the Afferent Pathways of the Central Nervous System

“…Several investigators have classified the normal cortical EEG of an unanesthetized rabbit into the alert, the resting and the mixed pattern (6)(7)(8). In the present experi ment, both the cortical and the hippocampal EEG pattern were taken as a measure to decide the type of basic EEG pattern of unanesthetized rabbits fixed stereotaxically.…”

Effects of Central Depressants and Stimulants on Eeg Alterations Induced by Carotid Cooling and Warming

“…The pretreatment of animals with methamphetamine, caffeine and physostigmine prevented the EEG alterations induced by the carotid warming, while pheniprazine, pipradrol and imipramine did not inhibit them. Kikuchi (6,7) reported that methamphetamine and pheniprazine caused the desynchronized pattern of the spontaneous EEG and that the threshold voltage of recruiting response was elevated by the administration of metham phetamine but not of pheniprazine. These results showed that the central stimulating action of pheniprazine was weaker than that of methamphetamine.…”