Effect of reperfusion therapy on index of myocardial performance in acute myocardial infarction: thrombolytics versus primary angioplasty

Abstract

It is known that primary angioplasty is more effective than thrombolytic therapy for the treatment of ST-segment elevation acute myocardial infarction. The aim of the present study is to compare the effects of the two strategies on the left ventricular functions using the Tei index (a combined myocardial performance index). Of 81 patients (11 female, mean age 52.7 +/- 11.9 years, and 70 male, mean age 54.8 +/- 11.5 years) matching the selection criteria, 41 patients were treated by primary percutaneous transluminal coronary angioplasty and stenting (group A, 41 patients) and 40 patients were treated by thrombolytic agents (streptokinase) (group B, 40 patients). All patients underwent a complete two-dimensional transthoracic echocardiographic and Doppler study in the left lateral decubitus position from multiple windows. There was no significant difference between the two groups in isovolumetric contraction time and ejection time. Isovolumetric relaxation time was 95.2 +/- 18.4 in group A and 116.2 +/- 28.1 in group B (P = 0.001) and the Tei index was 0.51 +/- 0.12 in group A and 0.59 +/- 0.16 in group B (P = 0.019). Isovolumetric relaxation time and Tei index were significantly higher in group B. Primary angioplasty is superior to thrombolytic therapy as assessed by the Tei index even in the first 3 h, with no apparent change in systolic function.

ESMO Symposium on Immuno-Oncology 2015 Officers and Organisation

“…The MPI (a combined myocardial performance index, Tei index) is an echocardiographic method for evaluation of global left ventricle systolic and diastolic function (8)(9)(10) . Calculation of MPI by echocardiography is easy and time saving method.…”

The Effect of Smoking on Myocardial Performance Index in Middle‐Aged Males after First Acute Myocardial Infarction

“…Successful early reperfusion or revascularization of culprit coronary lesion limits the infarct size and consequently preserves LV function and improves the MPI . Although smoking is considered to be the major modifiable risk factor for CAD, smokers have shown to have a better outcome after an acute MI in some former studies .…”

“…Successful early reperfusion or revascularization of culprit coronary lesion limits the infarct size and consequently preserves LV function and improves the MPI. 27,28 Although smoking is considered to be the major modifiable risk factor for CAD, smokers have shown to have a better outcome after an acute MI in some former studies. [6][7][8][9][10][11]29 A systematic review of the previous studies showing beneficial effects of smoking in the setting of acute MI have demonstrated that this paradox was not evident when confounding clinical variables were taken into consideration.…”