Effect of Remifentanil Combined Anesthesia on Cytokines and Oxidative Stress in Patients undergoing Laparoscopic Surgery for Colon Cancer

Ding, Suchun; Ma, Hongzhong; Wang, Gao; Zhenyu, Yu; Li, Kezhong; Huang, Aijie

doi:10.29271/jcpsp.2019.01.8

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…TNF- α and CRP are both essential substances involved in inflammation. TNF- α is a cytokine that changes at the early stage of inflammatory response, which has the role of triggering inflammatory response and promoting CRP secretion in the acute phase [ 23 ]. IL-6 is a multifunctional cytokine responsible for the liver's inflammatory response to infection or systemic inflammation, often referred to as the acute phase response.…”

Section: Discussionmentioning

confidence: 99%

Impact of Allogeneic Leukocyte-Depleted Red Blood Cell Transfusion on Inflammatory Response and Blood Coagulation in Patients with Recurrence of Colon Cancer after Operation

Geng

Liu

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Anemia inevitably affects the survival of cancer patients. In clinical practice, patients with anemia and decreased blood volume are treated by component blood transfusion. Through targeted blood transfusion therapy, the efficacy of blood transfusion treatment can be validly improved, which renders clinical benefits in reducing transfusion-induced adverse reactions (ARs). This research project mainly investigated the impact of allogeneic leukocyte-depleted red blood cell (LDRBC) transfusion on inflammatory response and coagulation status of patients with postoperative recurrence of colon cancer (CC). Methods. A total of 80 patients with postoperative recurrence of CC admitted to Changzhou Second People's Hospital affiliated to Nanjing Medical University from September 2017 to December 2020 were selected as the study subjects. 36 patients with allogeneic suspended red blood cell (RBC) transfusion were used as the control group (CG), and 44 patients receiving allogeneic LDRBC transfusion served as the observation group (OG). The two groups were compared regarding alterations in pretransfusion and posttransfusion serum inflammatory factors, stress indicators and coagulation function, incidence of ARs, postoperative infection, and average incision healing time. Results. After blood transfusion, serum tumor necrosis interleukin- (IL-) 6, IL-10, factor-α (TNF-α), and C-reactive protein (CRP) decreased in both cohorts, with lower parameters in CG ( P < 0.05 ); the stress indexes, adrenocortical hormone (ACTH), adrenaline (AD), norepinephrine (NE), and cortisol (Cor) increased, especially in CG ( P < 0.05 ); prothrombin time (PT), thrombin time (TT), and activated partial prothrombin time (APTT) in CG were lower than those in OG, and FIB was higher than that in OG with significant differences between two cohorts (all P < 0.05 ). The two groups had similar cases of lung infection and wound infection ( P > 0.05 ), but the incision healing time was evidently shorter in OG as compared to CG (9.73 ± 1.86 vs 14.67 ± 2.39 d, P < 0.05 ). The total incidence of ARs was 16.7% in CG and 6.9% in OG, with no significant difference ( P > 0.05 ). Conclusions. In the blood transfusion treatment for patients with postoperative recurrence of CC, LDRBC transfusion renders significant clinical benefits, which can effectively improve the coagulation function of patients, reduce stress reaction, and shorten incision healing time without increasing ARs during treatment and postoperative infection rate, which is worth popularizing.

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Section: Discussionmentioning

confidence: 99%

Impact of Allogeneic Leukocyte-Depleted Red Blood Cell Transfusion on Inflammatory Response and Blood Coagulation in Patients with Recurrence of Colon Cancer after Operation

Geng

Liu

2021

Evidence-Based Complementary and Alternative Medicine

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“…Serum cytokine levels were significantly lower in IL-8, IL-6, CRP, TNFα and MDA remifentanil group compared with the fentanyl group on the first day after surgery. 25 Serum SOD, GSH and catalase levels in the remifentanil group were found to be higher in the fentanyl group. 25 Shi et al 26 compared two different anaesthesia methods in terms of oxidative stress using propofol and sevoflurane in coronary artery bypass grafting operation.…”

Section: Discussionmentioning

confidence: 85%

“…25 Serum SOD, GSH and catalase levels in the remifentanil group were found to be higher in the fentanyl group. 25 Shi et al 26 compared two different anaesthesia methods in terms of oxidative stress using propofol and sevoflurane in coronary artery bypass grafting operation. During the operation, β-endorphin and MDA levels were found to be significantly higher than the preoperative levels in both groups.…”

Section: Discussionmentioning

confidence: 85%

“…The cortisol response can be changed by the anaesthetic intervention. 23 Ding et al 25 compared IL-8, IL-6, CRP and tumour necrosis factor alpha (TNFα) serum cytokine levels and superoxide dismutase (SOD), malondialdehyde (MDA), catalase and GSH oxidative stress index levels between fentanyl and remifentanil groups on the first day after surgery. Serum cytokine levels were significantly lower in IL-8, IL-6, CRP, TNFα and MDA remifentanil group compared with the fentanyl group on the first day after surgery.…”

Section: Discussionmentioning

confidence: 99%

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Stress response in vertebra surgery by total intravenous and inhalation anaesthesia

et al. 2021

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Oxidative stress can be created by an imbalance between the production of oxygen-containing free radicals known as reactive oxygen species (ROS) and their elimination. Although ROS are necessary for normal metabolism, such as killing external harmful factors and providing cellular signalling in cells, ROS overproduction can cause cellular dysfunction. 1 Free radicals are compounds containing unpaired electrons in one of their atomic or molecular orbits. They are reactive and short-lived. Free radicals can be produced as a continuation of a normal metabolism or by many reactions necessary for energy production in the cell. 2 ROS are highly reactive molecules and are produced as a result of normal metabolism in cell organelles, especially mitochondria, or due to causes such as ischaemia/reperfusion, aging, radiation, high oxygen pressure, inflammation and exposure to chemical agents. 3 Thiols are organic compounds that contain a sulfhydryl group (-SH) attached to a carbon atom and play an important role in defense against oxidative stress. The main thiols found in plasma are low molecular weight thiols including albumin, cysteine, cysteinylglycine, glutathione (GSH), homocysteine and γ-glutamyl cysteine. 4 Thiols are the most important reducing molecules in the body, oxidise ROS formed in the organism and reduce excess electrons, and disulfide bonds are formed. The disulfide bonds formed are reversible. It can turn into thiols depending on the antioxidant/oxidant balance of the organism. In this way, a dynamic thiol/disulfide homoeostasis (TDH) is preserved. 5

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“…In the present study, patients undergoing hernia repair under general anesthesia were selected for total intravenous anesthesia, and the effects of ketorolac tromethamine or dezocine alone or in combination on intraoperative hemodynamics and postoperative analgesia and sedation were considered. Hernia repair can stimulate the body to produce 5-hydroxytryptamine, [ 13 ] bradykinin, [ 14 ] histamine, [ 15 ] and other bioactive substances, as well as the accumulation of prostaglandin [ 16 ] and oxidative stress, [ 17 ] which will greatly enhance the pain caused by these substances. Although the incidence of pain in laparoscopic inguinal hernia repair is lower than that of traditional open surgery, the incidence of postoperative chronic pain is 12.7%, of which 83.3% of patients’ pain is located in the groin area.…”

Section: Discussionmentioning

confidence: 99%

Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair

Wu¹,

Cai²,

Li³

et al. 2022

Medicine

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Objective: To observe the effect of Ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative sedation in patients undergoing laparoscopic hernia repair. Methods: 100 male patients aged 60 to 80 years old, a line to elective laparoscopic inguinal hernia repair, were randomly divided into four groups: control group (Group A) and dezocine group (Group B), ketorolac tromethamine group (Group C), ketorolac tromethamine combined with dezocine group (Group D). Patients were administrated with 0.1 mg/kg dezocine in Group B, 0.5 mg/kg ketorolac in Group C, 0.1 mg/kg dezocine, and 0.5 mg/kg ketorolac in Group D, and with an equal dose of normal saline in group A. The heart rate (HR) and mean arterial pressure (MAP) of patients in 4 groups were recorded at each time point as follows, T0 (enter the operating room), T1 (before skin resection), 10 min after pneumoperitoneum (T2), mesh placement (T3), and laryngeal mask extraction (T4). Operation time, awakening time (time from drug withdrawal to consciousness recovery), the dosage of propofol, sufentanil, remifentanil, and intraoperative vasoactive drug dosage were recorded to compare. Visual analog scale score and sedation Ramsay score were evaluated 1, 6, 12, and 24 hours after extubation. Results: There was no significant difference in operation time, anesthesia recovery time, sufentanil dosage, and vasoactive drugs among all groups. The amount of propofol in Group B and D was less than that in Group A and C ( P < .05), and there was no difference between Group B and D, A and C ( P > .05). The amount of remifentanil in Group B, C, and D was less than that in Group A ( P < .05), and Group D was less than B and C ( P < .05). After extubation, HR and MAP were significantly higher than before ( P < .05). Compared with T0, HR and MAP increased in each group at T4, but MAP and HR in Group D increased the least ( P < .05). There were significant differences between Group B, C, D, and A, MAP and HR fluctuated little during extubation ( P < .05), but there was a significant difference between Group D and B, C ( P < .05). Visual analog scale scores of Group B, C, and D were lower than those of A at 1, 6, and 12 hours after surgery ( P < .05), and there was a significant difference between Group D, and B, C ( P < .05). Ramsay scores in Group B and D were higher than those in A and C at 1 and 6 hours after the operation ( P < .05). There was no difference in the incidence of adverse reactions among groups. Conclusion: The prophylactic use of ketorolac tromethamine and dezocine before laparoscopic inguinal hernia repair can reduc...

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Effect of Remifentanil Combined Anesthesia on Cytokines and Oxidative Stress in Patients undergoing Laparoscopic Surgery for Colon Cancer

Abstract: Institutional Review Board. A total of 154 patients undergoing laparoscopic colon cancer surgery were enrolled in this study. Inclusion criteria were patients who were diagnosed by colonoscopy and pathological examination, colon cancer TNM stage belonged to stage

Cited by 13 publications

References 19 publications

Impact of Allogeneic Leukocyte-Depleted Red Blood Cell Transfusion on Inflammatory Response and Blood Coagulation in Patients with Recurrence of Colon Cancer after Operation

Impact of Allogeneic Leukocyte-Depleted Red Blood Cell Transfusion on Inflammatory Response and Blood Coagulation in Patients with Recurrence of Colon Cancer after Operation

Stress response in vertebra surgery by total intravenous and inhalation anaesthesia

Effect of ketorolac tromethamine combined with dezocine prior administration on hemodynamics and postoperative analgesia in patients undergoing laparoscopic hernia repair

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