Effect of rectal administration of rebamipide on dextran sulfate sodium-induced colitis: Role of hepatocyte growth factor

Abstract

Rectal administration of rebamipide is effective for DSS-induced colitis in association with induction of HGF.

Inhibitory Potency of Marketed Drugs for Ulcerative Colitis and Crohn’s Disease on PEPT1

“…Rebamipide has been reported that it has a superior efficacy to the rat colitis model induced by dextran sulfate, 18,19) although rebamipide did not have a clinical application to IBD yet.…”

Effect of oral hepatocyte growth factor gene mediated by attenuated salmonella on 2‐, 4‐, 6‐trinitro‐benzene‐sulfonic‐acid‐induced ulcerative colitis in rat

“…On days 3,5,7,9,11,13, and 15 after the third gene transfer in the UC rats that were used to detect HGF expression, the colonic tissues treated with TPH were removed, and the paraffinembedded sections were analyzed for the HGF expression by immunohistochemistry. For HGF, the sections were treated with anti-human HGF monoclonal antibodies (R&D Systems, Minneapolis, MN, USA) followed by a treatment with peroxidaseconjugated goat anti-mouse immunoglobulins (Jackson ImmunoResearch Laboratories, West Grove, PA, USA).…”

“…[4][5][6][7][8] Among them, hepatocyte growth factor (HGF) plays multiple roles in enhancing colonic epithelium proliferation, inhibiting cell apoptosis, 9,10 reducing inflammatory infiltration, alleviating symptoms and mucosal lesions, 5,11 and improving local angiogenesis. [4][5][6][7][8] Among them, hepatocyte growth factor (HGF) plays multiple roles in enhancing colonic epithelium proliferation, inhibiting cell apoptosis, 9,10 reducing inflammatory infiltration, alleviating symptoms and mucosal lesions, 5,11 and improving local angiogenesis.…”

“…Growth factors have been shown to be involved in cellular proliferation, migration, and regeneration and ulcer healing and immune modulation. [4][5][6][7][8] Among them, hepatocyte growth factor (HGF) plays multiple roles in enhancing colonic epithelium proliferation, inhibiting cell apoptosis, 9,10 reducing inflammatory infiltration, alleviating symptoms and mucosal lesions, 5,11 and improving local angiogenesis. It also influences immune modulation.…”