Effect of oral hepatocyte growth factor gene mediated by attenuated salmonella on 2‐, 4‐, 6‐trinitro‐benzene‐sulfonic‐acid‐induced ulcerative colitis in rat

Ha, Xiaoqin; Yin, Qiang; Ling, Hui; Jia, Qinghua; Wang, Meiliang; Zhang, Junli; Xu, Yuebin; Chang, Ye-Wei; Yang, Xiaopeng

doi:10.1111/j.1440-1746.2011.06894.x

Cited by 4 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with the DSS model group, Eckol treatment decreased the number of CD4 + T cells, but increased the number of CD8 + T cells in the colonic tissues, suggesting that Eckol might contribute to inhibited CD4 + T-cell responses and enhanced CD8 + T-cell responses, resulting in an immunosuppressive micro-environment in chronic UC colons. Experimental evidence has shown that considerable ant-colitis agents or therapeutics reduced the ratio of CD4 + and CD8 + T lymphocytes in colonic tissues to maintain intestinal immune homeostasis, thereby helping to attenuate the progression of UC [39][40][41][42]. Similarly, our results demonstrate that Eckol increased CD11c + DCs and meanwhile decreased the ratio of CD4 + to CD8 + T cells, which might indicate the regulatory effect of Eckol on intestinal immune tolerance.…”

Section: Possible Involvement Of Toll-like Receptor 4 (Tlr4) Pathwaysupporting

confidence: 70%

“…Mar. Drugs 2023, 21, 376 7 shown that considerable ant-colitis agents or therapeutics reduced the ratio of CD4 CD8 + T lymphocytes in colonic tissues to maintain intestinal immune homeos thereby helping to attenuate the progression of UC [39][40][41][42]. Similarly, our results dem strate that Eckol increased CD11c + DCs and meanwhile decreased the ratio of CD CD8 + T cells, which might indicate the regulatory effect of Eckol on intestinal imm tolerance.…”

Section: Eckol Modulated the Infiltration Of Immune Cells In Dss-chal...supporting

confidence: 63%

See 1 more Smart Citation

Protective Effect and Mechanisms of Eckol on Chronic Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice

Liao,

Wei,

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

The use of functional foods and their bioactive components is receiving increasing attention as a complementary and alternative therapy for chronic ulcerative colitis (UC). This study explored the protective effect and mechanisms of Eckol, a seaweed-derived bioactive phlorotannin, on the dextran sodium sulfate (DSS)-induced chronic UC in mice. Eckol (0.5–1.0 mg/kg) reduced DSS-enhanced disease activity indexes, and alleviated the shortening of colon length and colonic tissue damage in chronic UC mice. The contents of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were significantly decreased, and the level of anti-inflammatory IL-10 was enhanced in the serum and colonic tissues collected from Eckol-treated mice compared with the DSS controls. Eckol administration significantly reduced the number of apoptotic cells and the expression of cleaved Caspase-3, and increased the B-cell lymphoma-2 (Bcl-2)/B-cell lymphoma-2- associated X (Bax) ratio in DSS-challenged colons. There were more cluster of differentiation (CD)11c+ dendritic cells and CD8+ T cells, and less CD4+ T cells infiltrated to inflamed colonic tissues in the Eckol-treated groups. Expression of colonic Toll-like receptor 4 (TLR4), nuclear factor kappa-B (NF-κB) p65, phosphorylated-signal transducer and activator of transcription (pSTAT)3 was significantly down-regulated by Eckol compared with the DSS-challenged group. In conclusion, our data suggest that Eckol appeared to be a potential functional food ingredient for protection against chronic UC. The anti-colitis mechanisms of Eckol might be attributed to the down-regulation of the TLR4/NF-κB/STAT3 pathway, inhibition of inflammation and apoptosis, as well as its immunoregulatory activity.

show abstract

Section: Possible Involvement Of Toll-like Receptor 4 (Tlr4) Pathwaysupporting

confidence: 70%

Section: Eckol Modulated the Infiltration Of Immune Cells In Dss-chal...supporting

confidence: 63%

Protective Effect and Mechanisms of Eckol on Chronic Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice

Liao,

Wei,

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…Some reports showed the increase of CD4 + T counts and CD4 + /CD8 + ratio indicates the aggravation of UC [ 19 ]. Meanwhile, the downregulation of accumulation of CD4 + and CD8 + can ameliorate the inflammation and colonic tissue damage [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Kangfuxin Liquid Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Ulcerative Colitis in Mice by Modulating Immune Response and Suppressing Inflammation

Tang

et al. 2021

Med Sci Monit Basic Res

View full text Add to dashboard Cite

Background The aim of this study was to determine the effect of kangfuxin liquid (KFXL) on inflammatory response, and its underlying mechanism in treating acute ulcerative colitis (UC) in mice induced by dextran sulfate sodium (DSS). Material/Methods Mice were provided drinking water containing DSS (3%) for 7 days to induce acute enteritis. The mice were divided into 6 groups: a control group, a DSS-induced (vehicle) group, a sulfasalazine (SASP) group, and low-, medium-, and high-dose kangfuxin liquid groups. Disease activity index (DAI), colon mucosa damage index (CMDI), histopathological score (HS), and organ index were monitored daily. The levels of interleukin-1β (IL-1β), interleukin-10 (IL-10) in serum and interleukin-17 (IL-17) and epidermal growth factor (EGF) in colon tissue were assessed by enzyme-linked immunosorbent assay (ELISA). Flow cytometry was used to assess the changes of T lymphocyte subsets in spleens of mice to evaluate the therapeutic effect of drugs on acute UC in mice. Results Different doses of kangfuxin liquid reduced the DAI, CMDI, and HS scores ( P <0.01 or P <0.05) of acute UC mice, reduced the level of IL-1β and IL-17 in serum, increased the expression of IL-10 in serum and EGF in colon tissue, increased the number of CD3 + T cells, and decreased the level of CD4 + T cells and the ratio of CD4 + /CD8 + . Conclusions Kangfuxin liquid has a therapeutic effect on DSS-induced acute UC in mice, and its mechanism of action may be associated with regulating immune function and reducing intestinal inflammatory response.

show abstract

Coatless alginate pellets as sustained-release drug carrier for inflammatory bowel disease treatment

Ramli

Wong

Naharudin

et al. 2016

Carbohydrate Polymers

View full text Add to dashboard Cite

Effect of oral hepatocyte growth factor gene mediated by attenuated salmonella on 2‐, 4‐, 6‐trinitro‐benzene‐sulfonic‐acid‐induced ulcerative colitis in rat

Abstract: TPH inhibits the proliferation of T lymphocytes and the antibody production of B lymphocytes. Furthermore, it ameliorates mucosal inflammation and promotes the regeneration of mucosa and the healing of the colonic ulceration.

Cited by 4 publications

References 17 publications

Protective Effect and Mechanisms of Eckol on Chronic Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice

Protective Effect and Mechanisms of Eckol on Chronic Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice

Kangfuxin Liquid Ameliorates Dextran Sulfate Sodium (DSS)-Induced Acute Ulcerative Colitis in Mice by Modulating Immune Response and Suppressing Inflammation

Coatless alginate pellets as sustained-release drug carrier for inflammatory bowel disease treatment

Contact Info

Product

Resources

About