Effect of recombinant human granulocyte colony stimulating factor (r-metHuG-CSF) as an adjunct to large-field radiotherapy: A phase I study

Haematopoietic Growth Factors in Children With Neutropenia

“…However, a median follow‐up of 20 months did not show a prolonged disease‐free survival. Similar results were reported by other authors (Sakata et al , 1993; Schmidberger et al , 1993; MacManus et al , 1995; Kolotas et al , 1996). On the other hand, a randomized phase III study in adults with limited‐stage small‐cell lung cancer showed that the administration of GM‐CSF (250 µg/m 2 twice daily) to patients receiving chemoradiotherapy increased both frequency and duration of life‐threatening thrombocytopenia ( P < 0·001).…”

Carboplatin and etoposide with hyperfractionated radiotherapy in children with newly diagnosed diffuse pontine gliomas: A phase I/II study

“…Thrombocytopenia, not neutropenia, was responsible for dose-limiting toxicity in most cases. This observation may reflect the safety and efficacy of administering G-CSF during radiation therapy as described in other reports [36,37].…”

G-CSF bei Radiochemotherapie

“…Vergleichbares berichten Hess et al [14] und Fushiki et al [11], die auBerdem weniger febrile Episoden und einen geringeren Antibiotikaverbrauch registrierten. Kolotas et al [18] zeigen bei alleiniger grogvolumiger Strahlentherapie ein gutes Ansprechen auf prophylaktische G-CSF-Gabe (dreimal w6chentlich wfihrend der Strahlentherapie) sowie eine kª Behandlungsdauer ira Vergleich zu einer Kontrollgruppe.…”