Effect of recombinant human bone morphogenetic protein-2 on bone formation in alveolar ridge defects in dogs

The effect of growth factors for bone augmentation to enable dental implant placement: A systematic review

“…BMPs have been shown to increase the formation of bone nodules in vitro [45][46][47][48][49][50][51][52][53][54][55][56] and stimulate bone formation in vivo. But the dosage applied in these clinical studies was several orders of magnitude higher than the concentration of naturally occurring BMPs [57].…”

Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid—An experimental study in rats

“…Collagen, collagen/HA/TCP, anorganic bovine bone, hyaluronic acid, PLA/PGA coated gelatine sponges and PGLA beads have been employed with various doses of either rhBMP-2, rhBMP4 or rhBMP7 [33][34][35][36][37][38][39] All carriers of these studies had been soak-loaded with their respective BMP solution, in one study rhBMP-2 was suspended in PGLA/dioxane solution and freeze-dried for implantation [40].…”

Expression of bone morphogenetic protein 2 and fibroblast growth factor 2 during bone regeneration using different implant materials as an onlay bone graft in rabbit mandibles

“…Such defects must be repaired with bone grafts or bone substitutes to ensure good structural and functional outcomes 1 . In the recent years, bone grafts and bone substitutes underneath barrier membranes have been increasingly utilized to optimize the treatment outcome of bone reconstructive therapy for defects in the alveolar process.…”