Effect of re-extraction parameters and drying temperature on the antioxidant properties and dietary fiber of Red sorrel (Hibiscus sabdariffa L.) calyces residues

Kalla, Marie Liliane Mouto; Jong, Emmanuel Nso; Kayem, Joseph; Sreekumar, M. M.; Nisha, P.

doi:10.1016/j.indcrop.2015.05.028

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…In contrast to our results, Jabuer et al (32) , after to analyse the proximate composition of DHSC, observed higher concentrations of carbohydrates, followed by ash, proteins and lipids. Regarding dietary fibre, in the present study, the concentration of soluble and insoluble fibres in the DHSC was higher than that reported by Kalla et al (33) , who found a total dietary fibre concentration of 6•15 g/100 g, with 5•86 g/100 g of insoluble fibre and 0•29 g/100 g of soluble fibre. However, higher concentrations of dietary fibre were reported by Sáyago-Ayerdi et al (31) , with a total dietary fibre concentration ranging from 36 to 39 g/ 100 g, in which soluble fibre ranged from 7•06 to 8•32 g/100 g and insoluble fibre from 13•0 to 17•08 g/100 g among different cultivars of H. sabdariffa calyces of whole flower stems analysed in the study.…”

Section: Centesimal Characterisation Dietary Fibre and Phenolic Compo...contrasting

confidence: 88%

Hibiscus (Hibiscus sabdariffaL.) supplementation increases butyrate synthesis and reduces inflammatory cells, attenuating the formation of aberrant crypt foci in BALB/c mice induced to pre-neoplastic lesions

et al. 2022

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The development of colorectal cancer involves some morphological changes, and in the initial stage, pre-neoplastic lesions called aberrant crypt foci (ACF) appear. Thus, an intervention with sources of bioactive compounds such as Hibiscus sabdariffa L., rich in phenolic compounds and anthocyanins, could attenuate the risk of developing these lesions due to its antioxidant, anti-inflammatory and anti-proliferative properties. Therefore, the aim of this study was to evaluate the effects of 5% and 10% supplementation of dehydrated H. sabdariffa calyces (DHSC) during the development of 1,2-dimethylhydrazine-induced preneoplastic lesions in male BALB/c mice. The characterization of DHSC was carried out. The in vivo experiment lasted 12 weeks, and the animals were randomly divided into 3 experimental groups: the control group (CON) and the supplemented groups with 5% DHSC and 10% DHSC. The activities of liver enzymes catalase and superoxide dismutase were determined. In addition, ACF, short chain fatty acids (SCFA), presence of inflammatory infiltrates, goblet cells and leukocytes in the colonic mucosa were quantified. There was a significant reduction in ACF and the presence of inflammatory infiltrates in the colon of animals in groups 5DHSC and 10DHSC. In addition, the 10DHSC group showed an increase in the activity of the catalse enzyme, in the production of butyrate and in the presence of NK cells in the colon, in addition to more hypertrophied goblet cells. Based on these findings, it is suggested that DHSC supplementation may be recommended to attenuate cellular responses in the early stage of preneoplastic lesions.

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Section: Centesimal Characterisation Dietary Fibre and Phenolic Compo...contrasting

confidence: 88%

Hibiscus (Hibiscus sabdariffaL.) supplementation increases butyrate synthesis and reduces inflammatory cells, attenuating the formation of aberrant crypt foci in BALB/c mice induced to pre-neoplastic lesions

et al. 2022

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“…Differently of our results, Jabuer et al (32) , after to analyze the proximate composition of DHSC was observed higher concentrations of carbohydrates, followed by ash, proteins, and lipids. Regarding dietary fiber, in the present study, the concentration of soluble and insoluble fibers in the DHSC was higher than that reported by Kalla et al (33) , who found a total dietary fiber concentration of 6.15 g / 100 g, with 5.86 g / 100 g of insoluble fiber and 0.29 g / 100 g of soluble fiber. However, higher concentrations of dietary fiber were reported by Sáyago-Ayerdi et al (31) , with a total dietary fiber concentration ranging from 36 to 39 g / 100g, in which soluble fiber ranged from 7.06 to 8.32 g / 100 g and insoluble fiber from 13.0 to 17.08 g / 100 g among different cultivars of H. sabdariffa calyces whole flower stems analyzed in the study.…”

Section: Centesimal Characterization Dietary Fiber and Phenolic Compo...contrasting

confidence: 90%

“…The HFD diet correlates with changes in the expression of oxidative stress and inflammatory markers that play an important role in promoting inflammation, immune response, cell proliferation and apoptosis. However, flavonoids reversed this situation (22,33,29) .…”

Section: Influence Of Flavonoids On Liver Changesmentioning

confidence: 99%

“…The phyla Firmicutes and Bacteroidetes dominate the microbiota of mice (92.6%), and ob/ob mice (genetically obese) show a 50% reduction in Bacteroidetes compared to a higher abundance of Firmicutes (32) . The induction of the obesity process in animals is related to the reduction of bacterial diversity, reduction of the phylum Bacteroidetes and increase of Firmicutes, contributing to a higher F/B ratio (33,34) .…”

Section: Influence Of Flavonoids On the Composition Of The Intestinal...mentioning

confidence: 99%

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Effects of hibisco (Hibiscus sabdariffa L.) intake on the development of preneoplastic lesions ando n the composition of the intestinal microbiota of Balb/c mice

Bernardes¹

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Colorectal câncer (CRC) includes morphological and pathological changes that affect the entire colon and rectum segment, with the appearance of aberrant crypt foci (ACF). ACFs are considered the first pre-neoplastic lesions that can progress to CRC. In addition to genetic factors, the development of CRC is also influenced by modifiable factors, that is, factors related to the individual's lifestyle. Therefore, changes related to lifestyle, such as the consumption of a diet rich in bioactive compounds, fibers, among others, contribute to reducing the risk of developing pre-neoplastic lesions and, consequently, CRC. Hibiscus sabdariffa L. is a medicinal plant belonging to the Malvaceae family, a source of bioactive compounds such as phenolic compounds, anthocyanins and dietary fiber. These compounds have antioxidant, anti-inflammatory, anti-proliferative properties, in addition to being hepatoprotective. Another possible mechanism of action of phenolic compounds in the body refers to the modulation of the intestinal microbiota, being metabolized by colonic bacteria producing metabolites and serving as a substrate for bacterial growth. In view of the above, the objective of the present study was to investigate whether the supplementation of 5% and 10% of dehydrated calyces of H. sabdariffa (DHSC) have the ability to attenuate the development of pre-neoplastic lesions, in addition to acting as prebiotics modulating the composition of the intestinal microbiota of mice. An in vivo experiment was carried out for 12 weeks, the animals were randomly divided into 3 experimental groups: the control group and the groups supplemented with 5% DHSC and 10% DHSC. During the first 8 weeks, the animals were induced to pre-neoplastic lesions with injection of the drug 1,2-Dimetilhidrazine (DMH). Manuscript 1: characterization of DHSC, determination of the activities of hepatic catalase and superoxide dismutase enzymes, ACF count, quantification of short-chain fatty acids, count of inflammatory infiltrates, goblet cells and leukocytes in the colonic mucosa. There was a significant reduction in ACF and in the presence of inflammatory infiltrates in the colon of animals in the 5DHSC and 10DHSC groups. The 10DHSC group showed an increase in the activity of the catalase enzyme, in the production of butyrate and in the presence of NK cells in the colon, in addition to more hypertrophied goblet cells. Based on these findings, it is suggested that DHSC supplementation may be recommended to attenuate cellular responses in the early stage of pre-neoplastic lesions. Manuscript 2: A systematic review was performed to elucidate the interaction of flavonoids with the microbiota and hepatic alterations in obesity-induced rats/mice. Studies were searched in PubMed, ScienceDirect and LILACS databases. Experimental studies that evaluated the influence of flavonoids on the composition of the microbiota and on hepatic alterations were included. After applying all exclusion criteria, the review consists of 15 experimental studies. It was shown that obesity-induced and flavonoid-treated mice showed an increase in bacterial diversity, a reduction in the abundance of bacteria associated with the consumption of a high-fat diet, such as Firmicutes, Proteobacteria, and an increase in the abundance of bacteria such as Bacteroidetes, Verrucomibrobia, Akkermansia, and Bifidobacterium. associated with improved metabolic and pathological status. Furthermore, flavonoids are able to reduce oxidative stress and inflammation of liver tissue. Finally, an association was observed between the composition of the microbiota and hepatic cholesterol through the metabolism of bile salts. Therefore, positive effects are suggested through the administration of flavonoids. Manuscript 3: Serum AST and ALT markers, hepatic cytokine profile, intestinal microbiota composition and expression of p53, c-Myc, caspase-3 and PCNA genes were determined. There was no difference between the experimental groups for serum markers of ASL and ALT and hepatic cytokines. Supplementation with 5% and 10% DHSC altered the composition of the intestinal microbiota, increasing the abundance of the Lachnospiraceae, Ruminococcaceae and Clostridiaceae families and the Clostridum genus, important butyrate producers. Furthermore, supplementation with 5% and 10% DHSC increased caspase-3 and c-Myc expression, respectively. Therefore, phenolic compounds, anthocyanins and dietary fiber contributed to modulate the composition of the intestinal microbiota, in addition to influencing the expression of genes associated with cellular apoptosis. Keywords: Colorectal Cancer. Microbiota. Hibiscus. Flavonoids. Anthocyanins.

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Porous Biodegradable Sodium Alginate Composite Fortified with Hibiscus Sabdariffa L. Calyx Extract for the Multifarious Biological Applications and Extension of Climacteric Fruit Shelf-Life

et al. 2022

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Effect of re-extraction parameters and drying temperature on the antioxidant properties and dietary fiber of Red sorrel (Hibiscus sabdariffa L.) calyces residues

Cited by 10 publications

References 30 publications

Hibiscus (Hibiscus sabdariffaL.) supplementation increases butyrate synthesis and reduces inflammatory cells, attenuating the formation of aberrant crypt foci in BALB/c mice induced to pre-neoplastic lesions

Hibiscus (Hibiscus sabdariffaL.) supplementation increases butyrate synthesis and reduces inflammatory cells, attenuating the formation of aberrant crypt foci in BALB/c mice induced to pre-neoplastic lesions

Effects of hibisco (Hibiscus sabdariffa L.) intake on the development of preneoplastic lesions ando n the composition of the intestinal microbiota of Balb/c mice

Porous Biodegradable Sodium Alginate Composite Fortified with Hibiscus Sabdariffa L. Calyx Extract for the Multifarious Biological Applications and Extension of Climacteric Fruit Shelf-Life

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