Effect of Raphanus sativus (Radish) Leaf Extract and High Doses of Atorvastatin on Body Weight, Liver Weight and Liver/Body Weight Ratio

Abstract

Background: Obesity is a global health problem. The chances of metabolic disorders such as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and atherosclerosis are increased due to obesity. Objective: (1) To determine effects of high doses of atorvastatin on body weight, liver weight and liver/body weight ratio in albino rabbits. (2) To compare the effect of three increasing doses of ethanolic extract of Raphanus sativus leaf with high doses of atorvastatin on body weight, liver weight and liver/body weight ratio in albino rabbits. Study Design: Experimental study.

Histomorphometric effects of Raphanus Sativus leaf ex-tract on Carbon Tetrachloride induced hepatotoxicity.

“…16 In our experiment, administration of CCl4 was followed by a reduction in the weight of the experimental animals whereas the animals receiving Raphanus Sativus showed a much less reduction in their weights, which is consistent with the findings of Anwar et al who observed that Raphanus Sativus ameliorates weight loss secondary to hepatotoxicity. 15 In this study, there was an increase in the LFTs of all the animals receiving CCl4 as compared with the controls. These findings are similar to the results reported by Baek et al and Jeongtae et al 16,17 However, LFT levels in the rats receiving adjunct therapy of Raphanus Sativus were far less than those who re- ceived CCl4 alone which is also consistent with the findings of Baek et al and Jeongtae et al 17,18 Rahman et al also reported a significant rise in LFT levels in experimental animals which received CCl4 but the experimental animals receiving concomitant Raphanus Sativus therapy showed near normal levels, which is consistent with the current study.…”