Effect of Quinal Barbitone, Dextroamphetamine, and Placebo on Apparent Time*

Goldstone, Sanford; Boardman, William K.; Lhamon, William T.

doi:10.1111/j.2044-8295.1958.tb00671.x

Cited by 56 publications

(21 citation statements)

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“…Furthermore, the accuracy of temporal discrimination is impaired by the neuroleptic haloperidol across a range of time intervals (Rammsayer 1989(Rammsayer , 1993(Rammsayer , 1997(Rammsayer , 1999. In contrast, the psychostimulant drug dextroamphetamine causes overestimation of stimulus durations (Goldstone et al 1958;Goldstone and Kirkham 1968), and caffeine has been shown to improve the estimation accuracy of durations in the range of seconds (at least at one particular dose in females; Botella et al 2001). Many studies of timing and its neural substrates have been conducted in laboratory animals, and their results are broadly consistent with those from human research in suggesting that psychoactive drugs can modulate the functioning of an internal clock.…”

Section: Introductionmentioning

confidence: 69%

“…The limited number of studies that have tested the effects of drugs on timing in people have generally supported the predictions of the pacemaker-counter model. Thus, for example, the sedative gas nitrous oxide alters time estimation and production in a manner consistent with a decrease in the internal timer rate (Adam et al 1974); alcohol has been shown to predispose the overproduction of time intervals (e.g., Tinklenberg et al 1972Tinklenberg et al , 1976, and secobarbital promotes the underestimation of stimulus durations (Goldstone et al 1958;Goldstone and Kirkham 1968). Furthermore, the accuracy of temporal discrimination is impaired by the neuroleptic haloperidol across a range of time intervals (Rammsayer 1989(Rammsayer , 1993(Rammsayer , 1997(Rammsayer , 1999.…”

Section: Introductionmentioning

confidence: 99%

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Dissociations between motor timing, motor coordination, and time perception after the administration of alcohol or caffeine

et al. 2008

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Rationale The impacts of psychoactive drugs on timing have usefully informed theories of timing and its substrates. Objectives The objectives of the study are to test the effects of alcohol and caffeine on the explicit timing involved in tapping with the implicit timing observed in the coordinated picking up of an object, and with the temporal discrimination. Materials and methods Participants in the "alcohol" experiment (N=16) received placebo, "low" (0.12 g/kg or 0.14 g/kg for women/men, respectively) or "high" (0.37 g/kg or 0.42 g/kg, respectively) doses of alcohol, and those in the "caffeine" experiment (N=16) received placebo, 200 or 400 mg caffeine. Time production variability was measured by repetitive tapping of specified intervals, and sources of variance attributable to central timer processes and peripheral motor implementation were dissociated. The explicit timing in tapping was compared with the implicit timing in the coordinated picking up of an object. Time perception was measured as discrimination thresholds for intervals of similar duration. Drug effects on reaction time were also measured. Results For tapping, alcohol significantly increased timer variability, but not motor variability; it did not affect coordination timing in the grip-lift task. Conversely, for time perception, the low dose of alcohol improved temporal discrimination. Caffeine produced no effects on any of the timing tasks, despite significantly reducing reaction times. Conclusions The effects of alcohol argue against a common clock process underlying time interval perception and production in the range below 1 s. In contrast to reaction time measures, time perception and time production appear relatively insensitive to caffeine.

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Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Dissociations between motor timing, motor coordination, and time perception after the administration of alcohol or caffeine

et al. 2008

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“…The findings that these tempos generally became faster under the condition where neurophysiological excitation was expected (Bell, 1966;Francois, 1927;Goldstone, Boardman, & Lhamon 1958;Hoagland, 1933), and became slower under the condition where neurophysiological inhibition was inferred (Baddeley, 1966;Bell, 1975;Cahoon, 1967) support indirectly Postulate 2.…”

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confidence: 74%

A developmental study of the role of learning processes in duration estimation

Matsuda

1987

Jpn. Psychol. Res

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A developmental study of the role of learning processes in duration estimationThe role of learning in accuracy of duration estimation was examined using the response duration schedule with 155 children in 6 groups between the ages of 3 and 9 years and with 20 adults.The main results were as follows: (a) Most children over 3 years 10 months of age could learn to estimate more or less exactly the duration of a 10s interval by using visual and the true value) decreased with age. (c) In the early learning period, response duration estimations were generally too short but lengthened rapidly in the later stages, though very long response durations were often shown by 3-year-old children in the early stages. (d) The ability to fine tune the duration estimation by using feedback increased with age. These findings were explained by Matsuda's model of duration estimation.

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“…Frankenhaeuser (1959), Goldstone, Boardman & Lhamon (1958), Hormia (1956) and Goldstone & Kirkham (1968) have all shown consistent findings with central depressants and stimulants and the subjective estimation of time. Amphetamines and related stimulants produce a subjective over estimation of a standard time interval while barbiturates produce an under estimation.…”

mentioning

confidence: 81%