2021
DOI: 10.1080/13880209.2021.2005636
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Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles

Abstract: Context As an inhibitor cytochrome P450 family 2 subfamily C polypeptide 8 (CYP2C8), quercetin is a naturally occurring flavonoid with its glycosides consumed at least 100 mg per day in food. However, it is still unknown whether quercetin and selexipag interact. Objective The study investigated the effect of quercetin on the pharmacokinetics of selexipag and ACT-333679 in beagles. Materials and methods The ultra-performance liquid chromatogra… Show more

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