Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update

Cheng, Wenhao; Xia, Kexin; Wu, Siyang; Li, Yingfei

doi:10.2174/1389200224666230116113240

Cited by 8 publications

(3 citation statements)

References 465 publications

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“…Conversely, negative interactions may lead to unwanted clinical consequences, especially for drugs with low therapeutic indices ( Zhou et al, 2021 ). HDIs may decrease efficiency, increase toxicity, and interfere with drug absorption and disposal processes due to interference from their pharmacological or pharmacokinetic effects ( Cheng et al, 2023 ). Approximately 25% of herbal supplement users frequently take prescription drugs, which increases the likelihood of HDIs.…”

Section: Discussionmentioning

confidence: 99%

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

Wei,

Su,

Cheng

et al. 2024

Front. Pharmacol.

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Objective: A remarkably sensitive, accurate, and efficient ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach was developed as a facile and expeditious method for measuring cilofexor concentration in beagle dogs, the herb-drug interactions between silybinin and cilofexor was explored based on pharmacokinetics.Methods: The plasma sample protein of the beagles were rapidly sedimented with acetonitrile, and cilofexor and tropifexor (internal standard, ISTD) were separated by gradient elution using a 0.1% formic acid aqueous solution and acetonitrile as the mobile phase. The concentrations were detected using positive ion multiple reaction monitoring (MRM) mode. Mass transfer pairs were m/z 587.91→267.91 for cilofexor and m/z 604.08→228.03 for ISTD, respectively. A two-period self-controlled experimental design was adopted for the HDIs experiment. In the first period (Group A), six beagle dogs were orally administered cilofexor at a dose of 1 mg/kg. In the second period (Group B), silybinin (3 mg/kg) was orally administered to the six beagle dogs twice a day for seven consecutive days, after which cilofexor was orally administered. The cilofexor concentration in beagle dogs was determined, and HDIs were evaluated based on their pharmacokinetics.Results: The accuracy and precision of cilofexor were both less than 15%, and the recoveries, matrix effects, and stability met the relevant requirements. The Cmax of cilofexor in group B was 49.62% higher than that in group A, whereas the AUC(0-t) and AUC(0−∞) of cilofexor in group B were 47.85% and 48.52% higher, respectively, than those in group A. Meanwhile, the t1/2 extended from 7.84 h to 9.45 h, CL and Vz decreased in Group B.Conclusion: A novel UPLC-MS/MS approach was successfully applied for the measurement of cilofexor in beagle dog plasma. Silybinin can alter the pharmacokinetics of cilofexor in beagle dogs, thereby increasing plasma exposure to cilofexor.

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Section: Discussionmentioning

confidence: 99%

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

Wei,

Su,

Cheng

et al. 2024

Front. Pharmacol.

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“…Although there are inconsistent reports as to the capacity of ginger to augment the actions of anticoagulant and antiplatelet drugs, caution may be warranted for those consuming ginger and being treated with blood thinners 117–122 . As measured in preclinical models, ginger and its constituents were reported to affect the activities of several cytochrome P450s and drug transporters that determine the metabolic disposition of various drugs 123–127 . Specifically, ginger was reported to alter the pharmacokinetics of the antibiotics ciprofloxacin, metronidazole, and isoniazid; the immunosuppressive agents tacrolimus and cyclosporine; and the anticancer medication crizotinib 128–131 .…”

Section: Safetymentioning

confidence: 99%

“…[117][118][119][120][121][122] As measured in preclinical models, ginger and its constituents were reported to affect the activities of several cytochrome P450s and drug transporters that determine the metabolic disposition of various drugs. [123][124][125][126][127] Specifically, ginger was reported to alter the pharmacokinetics of the antibiotics ciprofloxacin, metronidazole, and isoniazid; the immunosuppressive agents tacrolimus and cyclosporine; and the anticancer medication crizotinib. [128][129][130][131] Thus, caution is indicated for those taking such medications, and it is wise to consult a physician or clinical pharmacist prior to self-dosing.…”

Section: Safetymentioning

confidence: 99%

Ginger Update

Singletary

2023

Nutr Today

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The spice ginger is prepared from the rhizome of Zingiber officinale (Rosc.) belonging to the family Zingiberaceae. The unique aromas and flavors of the many cultivars make them suited for multiple food-related purposes. Besides being used in the preparation of pickles, candies, gingerbread, biscuits, soups, puddings, alcoholic beverages, and soft drinks, ginger and its extracts are also packaged in dietary supplements. Ginger has been a part of traditional medicine for thousands of years treating such ailments as gastrointestinal disorders, nausea, pain, cold, and asthma. In the past 10 to 15 years, a considerable number of preclinical and clinical studies have explored in more detail the potential of ginger to ameliorate diverse conditions such as nausea and vomiting, glycemic dysfunction, pain, and the metabolic syndrome. This narrative review provides an update on the clinical evidence related to potential benefits of ginger and discusses future research opportunities.

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P‐glycoprotein‐mediated herb–drug interaction evaluation between Tenacissoside G and paclitaxel

Hu,

et al. 2024

Biomedical Chromatography

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P‐glycoprotein (P‐gp)‐mediated herb–drug interactions (HDIs) may impact drug efficacy and safety. Tenacissoside G (Tsd‐G), a major active component of Marsdenia tenacissima, exhibits anticancer activity. To analyze the effect of Tsd‐G on the pharmacokinetics of paclitaxel (PTX), researchers selected 30 Sprague–Dawley (SD) rats, randomized into a solvent control group, a verapamil positive control group, and 20, 40, and 60 mg/kg Tsd‐G groups. After seven consecutive days of intraperitoneal injection of verapamil or Tsd‐G, a single dose of 6 mg/kg PTX was injected intravenously. Plasma samples were collected at different time points, and proteins were precipitated using a methanol–acetonitrile solution. An ultrahigh‐performance liquid chromatography–tandem mass spectrometry method was developed, with docetaxel as an internal standard, and quantified using positive ion multiple reaction monitoring (MRM) mode. This analytical method's specificity, accuracy, precision, recovery, matrix effect, and sample stability meet the requirements for biological sample determination. After Tsd‐G administration in rats, the mean residence time of PTX was significantly prolonged. And Tsd‐G can stably bind to P‐gp by forming hydrogen bonds and inhibiting the expression of P‐gp in rat liver. Although the metabolites of PTX were not detected in this study, the above results still indicate the existence of HDIs between Tsd‐G and PTX, and P‐gp may be the main target to mediate HDIs.

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Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update

Cited by 8 publications

References 465 publications

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

Ginger Update

P‐glycoprotein‐mediated herb–drug interaction evaluation between Tenacissoside G and paclitaxel

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