Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats

Abstract

Postprandial hyperglycemia is a major risk factor for diabetic complications leading to disabilities and mortality in diabetics. Quercetin, a flavonoid, has been tried in traditional medicine for treating diabetes. The present study was designed to evaluate the potential of quercetin to control postprandial blood glucose level after maltose and glucose loading in normal and STZ-induced diabetic rats. Normal male Albino wistar rats and STZ-induced diabetic rats were treated with 300 and 600 mg/kg quercetin orally to evaluate the effect on postprandial hyperglycemia after carbohydrate loading, using acarbose as comparator. The results clearly showed ameliorated postprandial hyperglycemia due to the use of quercetin (300 and 600 mg/kg), it significantly dampened the postprandial hyperglycemia by 32.0% and 64.0% respectively, in maltose loaded diabetic rats, and 30.3% after 300 mg/kg dose in normal rats, compared to control; while acarbose produced 51% and 54% decrease in this respect in the two models respecttively. Quercetin in 600 mg/kg dose produces significantly more reduction in postprandial hyperglycemia compared to acarbose, while in rats that received glucose and quercetin, postprandial hyperglycemia was not significantly affected. In conclusion, quercetin effectively suppresses postprandial hyperglycemia in STZ-induced diabetic rats loaded with maltose, which may be attributed to α-glucosidase inhibition. Quercetin could be used as a potential supplement for treating postprandial hyperglycemia

In vitro inhibitory effects of Sardinian Pistacia lentiscus L. and Pistacia terebinthus L. on metabolic enzymes: Pancreatic lipase, α‐amylase, and α‐glucosidase

“…As well, quercetin‐like myrcetin has been found in both Pistacia spp. A screening of the literature shows that quercitin posses several beneficial biological properties, it reduces blood glucose levels and improves plasma insulin levels in streptozotocin‐induced diabetic rats , in addition quercitin resulted a good candidate for preventing obesity‐related diseases . Luteolin‐7‐glucoside displayed pronounced capillary strengthening; reportedly protects from ischemic tissue injury (possibly due to its antioxidative and phosphodiesterase‐inhibiting properties).…”

Effects of Syzygium aromaticum-Derived Triterpenes on Postprandial Blood Glucose in Streptozotocin-Induced Diabetic Rats Following Carbohydrate Challenge

“…Commercially available synthetic inhibitors of carbohydrate hydrolyzing enzymes are effective in retarding carbohydrate hydrolysis and glucose absorption to suppress postprandial hyperglycaemia [ 8 ]. Quercetin, a flavonoid antioxidant, isolated from medicinal plants blunts postprandial hyperglycaemic spike via inhibition of carbohydrate hydrolysis [ 9 , 10 ]. Furthermore, α -glucosidase inhibitors with increased potency and lesser adverse effects than the existing drugs have also been isolated from medicinal plants [ 11 ].…”

Blood glucose‐lowering effect of Tectona grandis flowers in type 2 diabetic rats: A study on identification of active constituents and mechanisms for antidiabetic action 柚木花对2型糖尿病大鼠的降糖作用：一项鉴定其活性成份与降糖作用机制的研究

“…[41][42][43] In addition, QA has been reported to have an inhibitory action against α-glucosidase and α-amylase enzyme activity. [44][45][46] In T2D rats, RU reduced blood glucose and improved antioxidant levels. 47,48 In addition, RU has been reported to inhibit α-glucosidase enzyme and enhance glucose uptake in HepG2 cells.…”

“…Treatment of diabetic rats with QA was shown to result in increased islets number, reduced oxidative stress and stimulation of insulin release from isolated rat islets of Langerhans . In addition, QA has been reported to have an inhibitory action against α‐glucosidase and α‐amylase enzyme activity . In T2D rats, RU reduced blood glucose and improved antioxidant levels .…”