Blood glucose‐lowering effect of <scp>T</scp>ectona grandis flowers in type 2 diabetic rats: A study on identification of active constituents and mechanisms for antidiabetic action 柚木花对2型糖尿病大鼠的降糖作用：一项鉴定其活性成份与降糖作用机制的研究

Ramachandran, Subramaniam; Rajasekaran, A.

doi:10.1111/1753-0407.12121

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Recently, researchers have pursued novel natural compounds that can control blood glucose levels and effectively aid the management of diabetes without any side effects. Medicinal plants, such as Thymelaea hirsuta L., Tectona grandis flowers, Musa sapientum Linn., Asparagus officinalis L., Origanum majorana , Momordica charantia , Citrullus colocynthis , and Trigonella foenum‐graecum , are found to be better alternatives than current treatment regimens, such as sulfonylureas . The bioactive compounds present in medicinal plants are very effective in the treatment of diabetes .…”

Section: Discussionmentioning

confidence: 99%

Retracted: Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles usingPouteria sapotain streptozotocin‐induced diabetic rats

Prabhu

Vinodhini

Elanchezhiyan

et al. 2017

Journal of Diabetes

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Background: Medicinal plants and green synthesis of silver nanoparticles (AgNPs) have proven to be good sources of agents effective in the treatment of diabetes mellitus. The present study focused on the green synthesis of AgNPs from the aqueous leaf extract of Pouteria sapota in order to evaluate the in vitro and in vivo antidiabetic properties of this extract and the synthesized AgNPs. Methods: The AgNPs were biologically synthesized under ambient conditions from an aqueous leaf extract of P. sapota using the hot percolation method and were characterized using spectroscopic methods, X-ray diffraction, and scanning electron microscopy. The in vitro antidiabetic activity of the aqueous leaf extract and AgNPs was confirmed by non-enzymatic glycosylation of hemoglobin, glucose uptake by yeast cells following exposure of cells to 5 or 10 mmol/L glucose solution, and inhibition of α-amylase. Further, in vivo antidiabetic activity was assessed in streptozotocin-induced rats. Rats were treated with aqueous leaf extract (100 mg/kg) or AgNPs (10 mg/kg) for 28 days. Following treatment, rats were killed for biochemical and histopathological analysis of kidney and liver samples. Results: A significant reduction in blood sugar levels was noted in rats treated with leaf extract or AgNPs. Results of in vitro and in vivo analyses in rats treated with leaf extract or AgNPs show that both the extract and the biologically synthesized AgNPs have antidiabetic activity. Conclusion: The aqueous leaf extract of P. sapota and AgNPs exhibited efficient antidiabetic activity in the rat model of diabetes and therefore could have potential for development for medical applications in the future.

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Section: Discussionmentioning

confidence: 99%

Retracted: Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles usingPouteria sapotain streptozotocin‐induced diabetic rats

Prabhu

Vinodhini

Elanchezhiyan

et al. 2017

Journal of Diabetes

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“…In addition, application of this extract to type 2 diabetic rats significantly reduced their blood glucose level. The active polyphenols present in this extract impart a blood glucose-lowering effect via insulin sensitization as well as inhibition of α-amylase and α-glucosidase activities (Ramachandran and Rajasekaran, 2014). Commercial phaseolamin, which has high α-amylase inhibitory ability, can reduce the blood glucose levels in streptozotocin-induced diabetic rats; therefore, it possesses therapeutic potential for the treatment or prevention of the complications of diabetes (De Gouveia et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Optimization Extraction Conditions with Ultrasound for Anti-hyperglycemic Activities from Psidium guajava Leaf

Liu

Wang

Huang³

et al. 2015

FSTR

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The present study evaluated the optimal parameters for Psidium guajava leaf extraction by ultrasound to obtain maximal anti-hyperglycemic activities in the extract. The response surface methodology was employed for empirical model building. The maximum inhibition of the two starch-digesting enzymes α-amylase and α-glucosidase was determined. The optimized extraction parameters of solvent-to-solid ratio, extraction time, and extraction temperature for obtaining the maximum inhibitory activity for 50 µg/mL extract were determined to be the following: 12.07 (v/w), 5.22 min, and 59.77℃ for α-amylase (47.23% ± 0.76%) and 12 (v/w), 5.22 min, and 59.94℃ for α-glucosidase (59.42% ± 0.65%), respectively. The F values for the lack-of-fit were not significant ( p > 0.05) for both second-order models, indicating them to be appropriate for describing the response surface. In conclusion, our study presents the optimal conditions for ultrasound-assisted extraction of guava leaf as a potential substance for use in diabetes treatment.

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“…This enzyme acts to inhibit glucose absorption in the small intestine. The antidiabetic activity of PM through inhibition of α-glucosidase was also concluded by Elya et al (5) The fruit of PM is thought to contain flavonoids that can increase insulin secretion, alter the metabolism of Ca 2+ (25) and regenerate the pancreatic islets of Langerhans, particularly the β-cells. (26) Similar findings were obtained in the study that was conducted by Arjadi and Mustafa (27) who concluded that PME can decrease the blood glucose level in diabetic rats, and regenerate the cells of the pancreatic islets of Langerhans of diabetic rats.…”

Section: Discussionmentioning

confidence: 69%

Hypoglycemic effect of Phaleria macrocarpa (Scheff.) Boerl dry extract in healthy adults

et al. 2018

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Background The prevalence of diabetes in Indonesia continues to increase and causes many complications. Fruits of Phaleria macrocarpa (Scheff.) Boerl. (PM) are used in the traditional health system of the Indonesians, as effective remedy in the management of diabetes mellitus. The aim of this study was to evaluate the effect and magnitude of doses of PM dry fruit extract (PME) on blood glucose levels in healthy adults. Methods This research was of pre-posttest design involving 30 healthy volunteer subjects aged 20-55 years receiving glucose loads. At pre-test the subjects were given orally 75 g glucose, and at post-test they were given PME at doses of 125 mg and 250 mg. Data collection included anthropometric examination and blood glucose level. The area under the curve (AUC) of blood glucose levels was measured at 0, 15, 30, 60, 120 and 180 minutes. Data analysis was performed using paired t-test with p <0.05. Results The percentage of reduction in AUC between pre- and post-test after administration of PME 125 mg was 12.1% and significant (p=0.000). But the percentage of reduction in AUC between pre- and post-test after administration of PME 250 mg was 4.07% and not significant (p=0.06). The reduction in AUC between post-test PME 125 mg vs PME 250 mg showed significant results (p=0.011). Conclusion This study demonstrated that a dose of 125 mg Phaleria macrocarpa (Scheff.) Boerl. dry extract has a hypoglycemic effect in healthy adults, and may therefore be suitable for use as traditional anti-diabetic drug.

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Blood glucose‐lowering effect of Tectona grandis flowers in type 2 diabetic rats: A study on identification of active constituents and mechanisms for antidiabetic action 柚木花对2型糖尿病大鼠的降糖作用：一项鉴定其活性成份与降糖作用机制的研究

Abstract: Polyphenolic active constituents present in METGF are possibly responsible for the blood glucose-lowering effect in T2D rats via an insulin-sensitizing action, as well as inhibition of α-amylase and α-glucosidase activity.

Cited by 6 publications

References 40 publications

Retracted: Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles usingPouteria sapotain streptozotocin‐induced diabetic rats

Retracted: Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles usingPouteria sapotain streptozotocin‐induced diabetic rats

Optimization Extraction Conditions with Ultrasound for Anti-hyperglycemic Activities from <i>Psidium guajava</i> Leaf

Hypoglycemic effect of Phaleria macrocarpa (Scheff.) Boerl dry extract in healthy adults

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