The present investigation on bioefficacy of insecticide against Bemicia tabaci infesting Bt cotton in field condition was carried out at Cotton Research Station, Junagadh Agricultural University, Junagadh during kharif, 2020-21 & 2021-22. Considering the efficacy and yield, afidopyropen 50 g/l DC 0.010 % found the most effective treatment over rest of the treatments as it occupied the first rank with yield (2538 kg/ha). The next best treatments were pyriproxyfen 10 + bifenthrin 10 EC 0.024 % with yield (2332 kg/ha), and pyriproxyfen 10 EC 0.020 % with yield (2195 kg/ha) stood in the second and the third position in yield and efficacy. Based on ICBR, the result among different treatments indicated that the pyriproxyfen 10 + bifenthrin 10 EC 0.024 % gave the highest incremental cost benefit ratio of 1:14.80. The next in order being pyriproxyfen 10 EC 0.020 % (1:12.35), afidopyropen 50 g/l DC 0.010 % (1:8.52).