Effect of pyrethroids on female genital system. Review

Marettová, E.; Maretta, M.; Legáth, Jaroslav

doi:10.1016/j.anireprosci.2017.07.007

Cited by 48 publications

(16 citation statements)

References 63 publications

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“…The potential hormonal activity of DLM has multiple effects on the endocrine system. The decreased levels of estradiol upon DLM treatment are consistent with those reported by (Marettovaa et al, 2017). Calculating serum testosterone and estradiol appears to be a more reliable tool than measuring serum testosterone only in assessment of male fertility (Gomaa et al, 2018).…”

Section: Discussionsupporting

confidence: 82%

Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Maksoud

Mahfouz

Soliman

et al. 2018

Benha Veterinary Medical Journal

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A B S T R A C TA total number of 80 Wister male rats, 9 -wk. old were taken, weighed and divided into four experimental groups to investigate the effect of Deltamethrin (DLM) oral administration (0.87, 8.7 and 17.4 mg/kg B.W) for a period of 9 weeks on reproductive organs and fertility indices of Wister male rats. The results indicated that DLM caused a significant reduction in Testis weights, sperm count, motility and viability and fructose in semen. Also induced decreases in serum FSH, LH and Estradiol levels however increase in sperm abnormalities. These results indicated that DLM is a toxic pyrethroid pesticide that produced significant reproductive toxicity in treated male rats as revealed by the severely affected parameters (Key word: DLM, Reproductive toxicity, Sperm quality) (http://www.bvmj.bu.edu.eg) (bvmj, 35 (1): 311-318, SEPT.., 2018)

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Section: Discussionsupporting

confidence: 82%

Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Maksoud

Mahfouz

Soliman

et al. 2018

Benha Veterinary Medical Journal

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“…Women who reported indoor residual pyrethroid spray-ing had 25% lower AMH concentrations compared with women who reported no spraying, although there was only limited evidence for associations with DDT spraying. Prior reviews have suggested links between pesticide exposure and ovarian toxicity leading to female infertility, including premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS), menstrual problems and altered sex steroid hormone synthesis [29,[36][37][38][39], although the effects were likely dose-dependent and agent specific [40], and varied with the timing of the exposure [41].…”

Section: Ovarian Reserve and Hormone Levelsmentioning

confidence: 99%

Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides

Fučić

Duca

Galea

et al. 2021

IJERPH

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A marked reduction in fertility and an increase in adverse reproductive outcomes during the last few decades have been associated with occupational and environmental chemical exposures. Exposure to different types of pesticides may increase the risks of chronic diseases, such as diabetes, cancer, and neurodegenerative disease, but also of reduced fertility and birth defects. Both occupational and environmental exposures to pesticides are important, as many are endocrine disruptors, which means that even very low-dose exposure levels may have measurable biological effects. The aim of this review was to summarize the knowledge collected between 2000 and 2020, to highlight new findings, and to further interpret the mechanisms that may associate pesticides with infertility, abnormal sexual maturation, and pregnancy complications associated with occupational, environmental and transplacental exposures. A summary of current pesticide production and usage legislation is also included in order to elucidate the potential impact on exposure profile differences between countries, which may inform prevention measures. Recommendations for the medical surveillance of occupationally exposed populations, which should be facilitated by the biomonitoring of reduced fertility, is also discussed.

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“…With the phasing out of the varieties of organochlorine and organophosphorus pesticides, pyrethroids have been widely applied to agricultural production, household use, and public health places ( 6 ). Pyrethroids often show more advantages than traditional insecticides due to their increased environmental stability and toxicity toward insects ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

Zhang

Ren

et al. 2021

Front. Endocrinol.

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Pyrethroids may be related to male reproductive system damage. However, the results of many previous studies are contradictory and uncertain. Therefore, a systematic review and a meta-analysis were performed to assess the relationship between pyrethroid exposure and male reproductive system damage. A total of 72 articles were identified, among which 57 were selected for meta-analysis, and 15 were selected for qualitative analysis. Pyrethroid exposure affected sperm count (SMD= -2.0424; 95% CI, -2.4699 to -1.6149), sperm motility (SMD=-3.606; 95% CI, -4.5172 to -2.6948), sperm morphology (SMD=2.686; 95% CI, 1.9744 to 3.3976), testis weight (SMD=-1.1591; 95% CI, -1.6145 to -0.7038), epididymal weight (SMD=-1.1576; 95% CI, -1.7455 to -0.5697), and serum testosterone level (SMD=-1.9194; 95% CI, -2.4589 to -1.3798) in the studies of rats. We found that gestational and lactational exposure to pyrethroids can reduce sperm count (SMD=1.8469; 95% CI, -2.9010 to -0.7927), sperm motility (SMD=-2.7151; 95% CI, -3.9574 to -1.4728), testis weight (SMD=-1.4361; 95% CI, -1.8873 to -0.9848), and epididymal weight (SMD=-0.6639; 95% CI, -0.9544 to -0.3733) of F1 offspring. Exposure to pyrethroids can increase malondialdehyde (SMD=3.3451; 95% CI 1.9914 to 4.6988) oxide in testes and can reduce the activities of glutathione (SMD=-2.075; 95% CI -3.0651 to -1.0848), superoxide dismutase (SMD=-2.4856; 95% CI -3.9612 to -1.0100), and catalase (SMD=-2.7564; 95% CI -3.9788 to -1.5340). Pyrethroid exposure and oxidative stress could damage male sperm quality. Gestational and lactational pyrethroid exposure affects the reproductive system of F1 offspring.

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Effect of pyrethroids on female genital system. Review

Cited by 48 publications

References 63 publications

Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Biochemical Role of Pyrethroids on Male Fertility and Seminal Profile of Rat

Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides

Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

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