Effect of PVP K30 and/or<scp>l</scp>-Arginine on Stability Constant of Etoricoxib–HPβCD Inclusion Complex: Preparation and Characterization of Etoricoxib–HPβCD Binary System

Shah, Manali; Karekar, Poonam; Sancheti, Pankajkumar; Vyas, Vikrant; Pore, Yogesh

doi:10.1080/03639040802220292

Cited by 17 publications

(5 citation statements)

References 44 publications

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“…However, some crystalline traces were still observable which might be due to crystalline natured βCD, CA, and AA. Whereas, for HPβCD binary PH [Figure 4G] and ternary PHC [Figure 4I], PHA [Figure 4K] systems, these peaks were observed to be completely diffused or disappeared, endorsing amorphization of PIP achieved by lyophilization technique [31] and formation of inclusion complexation with CDs, which was further contributed for improvement in physicochemical properties of PIP. [21,32]…”

Section: Xrpdmentioning

confidence: 98%

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Jadhav¹

2021

AJP

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Introduction: Piperine (PIP) is a natural ingredient possessing important biological activities. However, its practical usefulness is limited due to its low water solubility. In our previous research article (PART A), we demonstrated inclusion complexation of PIP with cyclodextrins (CDs) in the influence of certain hydroxy acids resulted in tremendous improvement in physicochemical characteristics of PIP. The aim of current research work was to study biological properties and stability analysis of PIP and its lyophilized inclusion complexes. Materials and Methods: Initially, Job's plot experiment was carried out to assess the type of solubility and stoichiometry of complexes. The solid inclusion complexes were obtained by lyophilization and characterized by differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), saturation solubility, in-vitro dissolution, in-vitro antioxidant activity, and in-vivo anti-inflammatory activity in carrageenan-induced rat paw edema model. The short-term stability studies were carried out as per the ICH guidelines. Results: During assessment, the complexes performed better in terms of in-vitro antioxidant and in-vivo anti-inflammatory activities than the native PIP. However, PIP: Hydroxypropyl β-CD (HPβCD): Ascorbic acid (AA) ternary complexes elicited immediate and maximum onset of anti-inflammatory action, as compared to other test samples. In the stability studies, no noteworthy changes were recorded concerning DSC, XRPD, and in-vitro dissolution studies over a period of 6 months except complexes with HPβCD. Conclusion: Taking everything into account, complexation of PIP with CDs, in the influence of AA, would be a successful way to improve its biological properties.

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Section: Xrpdmentioning

confidence: 98%

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Jadhav¹

2021

AJP

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“…The composition is fat (1%), protein (35%), carbohydrates (51%), minerals (7%), and moisture (3.5%) (Table 1). SMP is composed of alpha‐, beta‐, and kappa‐casein and acts as an emulsifying agent for oral pharmaceutical preparations (Shah et al., 2009). SMP can enhance drug solubility due to the hydrophobic protein component, that is, casein being entrapped in to a lipophilic/hydrophobic drug, and the reaction (inclusion complex) is caused by β‐casein acting as a surfactant.…”

Section: Introductionmentioning

confidence: 99%

Application of the Box–Behnken design for the production of soluble curcumin: Skimmed milk powder inclusion complex for improving the treatment of colorectal cancer

Mohamed

Alqahtani

Venkatesan

et al. 2020

Food Science & Nutrition

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“…The polymers are believed to enhance the stability constants of drug–CD complexes, the interactions with drug–CD complexes and the interactions with the outer surfaces of CDs [ 79 ]. The addition of water-soluble polymers supplies an advantage through the complexation efficiency of HPβCD by establishing molecular interactions based on the solubilization of the amorphous form of cefuroxime axetil, such as Van der Waals dispersion forces, hydrophobic bonds or hydrogen bonds in the presence of PVP [ 80 ]. The particle size revealed that the binary and multicomponent complexes were micro-sized.…”

Section: Water-soluble Polymers As Auxiliary Agentsmentioning

confidence: 99%

Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

et al. 2021

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Cyclodextrins (CDs) are naturally available water-soluble cyclic oligosaccharides widely used as carriers in the pharmaceutical industry for their ability to modulate several properties of drugs through the formation of drug–CD complexes. The addition of an auxiliary substance when forming multicomponent complexes is an adequate strategy to enhance complexation efficiency and to facilitate the therapeutic applicability of different drugs. This review discusses multicomponent complexation using amino acids; organic acids and bases; and water-soluble polymers as auxiliary excipients. Special attention is given to improved properties by including information on the solubility, dissolution, permeation, stability and bioavailability of several relevant drugs. In addition, the use of multicomponent CD complexes to enhance therapeutic drug effects is summarized.

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Effect of PVP K30 and/orl-Arginine on Stability Constant of Etoricoxib–HPβCD Inclusion Complex: Preparation and Characterization of Etoricoxib–HPβCD Binary System

Cited by 17 publications

References 44 publications

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Application of the Box–Behnken design for the production of soluble curcumin: Skimmed milk powder inclusion complex for improving the treatment of colorectal cancer

Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

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