Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

Aiassa, Virginia; Garnero, Claudia; Longhi, Marcela R.; Zoppi, Ariana

doi:10.3390/pharmaceutics13071099

Cited by 45 publications

(29 citation statements)

References 108 publications

(152 reference statements)

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“…For these methods, using some materials as drug carrier systems, cyclodextrins (CDs) have been of interest in the pharmaceutical industry [14][15][16][17]. CDs are used as complexing agents by forming inclusion complexes with different poorly soluble drugs, because of their availability, water-solubility, and biocompatibility [18]. Moreover, CDs can be used to reduce gastrointestinal drug irritation, convert liquid drugs into microcrystalline or amorphous powder, and prevent drug-drug and drug-excipient interactions [19].…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

et al. 2022

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Polymers and their composites have recently attracted attention in both pharmaceutical and biomedical applications. Polyethylene glycol (PEG) is a versatile polymer extensively used in medicine. Herein, three novel PEG-based polymers that are pseudopolyrotaxane (PEG/α-CD) (1), titania–nanocomposite (PEG/TiO2NPs) (2), and pseudopolyrotaxane–titania–nanocomposite (PEG/α-CD/TiO2NPs) (3), were synthesized and characterized. The chemical structure, surface morphology, and optical properties of the newly materials were examined by FT-IR, 1H-NMR, SEM, and UV–Vis., respectively. The prepared polymers were used as drug carriers of sulfaguanidine as PEG/α-CD/Drug (4), PEG/TiO2NPs/Drug (5), and PEG/α-CD/TiO2NPs/Drug (6). The influence of these drug-carrying formulations on the physical and chemical characteristics of sulfaguanidine including pharmacokinetic response, solubility, and tissue penetration was explored. Evaluation of the antibacterial and antibiofilm effect of sulfaguanidine was tested before and after loading onto the prepared polymers against some Gram-negative and positive bacteria (E. coli, Pseudomonas aeruginosa, and Staphylococcus aureus (MRSA)), as well. The results of this work turned out to be very promising as they confirmed that loading sulfaguanidine to the newly designed polymers not only showed superior antibacterial and antibiofilm efficacy compared to the pure drug, but also modified the properties of the sulfaguanidine drug itself.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

et al. 2022

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“…Therefore, they will not be discussed in this article. Moreover, the benefits resulting from encapsulation of various molecules in the form of CD complexes will not be described here, as there are other (recent and excellent) reviews on this topic [17][18][19]. Therefore, this paper will begin with a brief summary of the concepts of MD simulations, followed by solutions that are frequently used to properly model the CD complexes by its means.…”

Section: Molecular Modeling Of CD Host-guest Complexes-theoretical and Practical Aspectsmentioning

confidence: 99%

Application of Molecular Dynamics Simulations in the Analysis of Cyclodextrin Complexes

Mazurek

Szeleszczuk

Gubica

2021

IJMS

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Cyclodextrins (CDs) are highly respected for their ability to form inclusion complexes via host–guest noncovalent interactions and, thus, ensofance other molecular properties. Various molecular modeling methods have found their applications in the analysis of those complexes. However, as showed in this review, molecular dynamics (MD) simulations could provide the information unobtainable by any other means. It is therefore not surprising that published works on MD simulations used in this field have rapidly increased since the early 2010s. This review provides an overview of the successful applications of MD simulations in the studies on CD complexes. Information that is crucial for MD simulations, such as application of force fields, the length of the simulation, or solvent treatment method, are thoroughly discussed. Therefore, this work can serve as a guide to properly set up such calculations and analyze their results.

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“…G-825-6 could produce mainly CD8-CD12 [5]. Although CD6-CD8 are widely used in food, cosmetic, and pharmaceutical industries to stabilize or enhance solubility of the guest molecules [6][7][8][9], LR-CD applications are limited due to small quantities obtained during synthesis and lack of efficient separation techniques.…”

Section: Introductionmentioning

confidence: 99%

Production of Large-Ring Cyclodextrins by Amylomaltases

et al. 2022

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Amylomaltase is a well-known glucan transferase that can produce large ring cyclodextrins (LR-CDs) or so-called cycloamyloses via cyclization reaction. Amylomaltases have been found in several microorganisms and their optimum temperatures are generally around 60–70 °C for thermostable amylomaltases and 30–45 °C for the enzymes from mesophilic bacteria and plants. The optimum pHs for mesophilic amylomaltases are around pH 6.0–7.0, while the thermostable amylomaltases are generally active at more acidic conditions. Size of LR-CDs depends on the source of amylomaltases and the reaction conditions including pH, temperature, incubation time, and substrate. For example, in the case of amylomaltase from Corynebacterium glutamicum, LR-CD productions at alkaline pH or at a long incubation time favored products with a low degree of polymerization. In this review, we explore the synthesis of LR-CDs by amylomaltases, structural information of amylomaltases, as well as current applications of LR-CDs and amylomaltases.

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Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

Cited by 45 publications

References 108 publications

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

Application of Molecular Dynamics Simulations in the Analysis of Cyclodextrin Complexes

Production of Large-Ring Cyclodextrins by Amylomaltases

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