Effect of Psoriasis Activity on Metalloproteinase‐1 and Tissue Inhibitor of Metalloproteinase‐1 in Plasma and Lesional Scales

Abstract

The aim of this study was to evaluate the association between psoriasis severity and concentrations of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in plasma and scales from psoriatic lesions, measured with an enzyme immunoassay in 24 patients and analysed with respect to psoriasis area and severity index (PASI). The mean plasma concentrations of both proteins in psoriatic patients significantly exceeded the control values. The proteins were also detectable in scales. There was a significant correlation between plasma MMP-1 concentration and the disease duration. The PASI values showed significant positive correlation with plasma TIMP-1 and significant negative correlation with MMP-1 content in scales. The highest plasma MMP-1 concentration was observed in patients with mild forms whereas the highest plasma TIMP-1 concentrations were demonstrated in severe forms of psoriasis. Our results confirm the role of these proteins in pathogenesis of psoriasis. In severe forms, a decrease in both MMP-1 and TIMP-1 was observed in scales, suggesting their insufficient tissue expression, which can be a crucial element of psoriasis aggravation.

Plasma TGF-β1, TIMP-1, MMP-1 and IL-18 as a combined biomarker of psoriasis activity

“…Since vascular endothelial growth factor (VEGF) demonstrates correlation with some MMPs, this effect can also be associated with inhibition of angiogenesis (Simonetti et al 2006). As we showed previously and confirmed in this study plasma concentrations of TIMP-1 demonstrate a significant positive correlation whereas MMP-1 demonstrate a significant negative correlation with the PASI score (Flisiak et al 2006a). Additionally we demonstrated elevated concentrations of MMP-1 in scales from psoriatic lesions, but levels decreased in patients with a more severe form of the disease.…”

“…Some research has demonstrated TIMP-1 overexpression in psoriatic lesions and its elevated levels in serum (Myers et al 2004, Flisiak et al 2005, 2006a. TIMP-1 overexpression causes inhibition of MMP activity and as a consequence decrease of collagen degradation.…”

Effect of psoriasis activity on VEGF and its soluble receptors concentrations in serum and plaque scales

“…One of the most important inhibitors of epithelial cell proliferation is TGF-b 1 which demonstrate an association with psoriasis severity and treatment efficacy [11,12]. TGF-b is a strong stimulus for tissue inhibitors of metalloproteinases (TIMP), affecting the activity of extracellular matrix metalloproteinases (MMP) responsible for collagen degradation [20]. Since VEGF demonstrates correlation with some MMPs, this effect can also be associated with angiogenesis [1].…”

The Increased Expression of Matrix Metalloproteinase-9 Messenger RNA in the Non-lesional Skin of Patients with Large Plaque Psoriasis Vulgaris

“…Therefore, the elevation of the MMP-1 mRNA expression in the lesional skin is thought to be the secondary response to the inflammatory cytokines that are produced in psoriasis lesions. However, Flisiak et al 30,31 reported that the elevated levels of MMP-1 and TIMP-1 in psoriatic plasma and the levels of MMP-1 and TIMP-1 in psoriatic plasma were inversely correlated to the disease severity (a decrease in MMP-1 and an increase in TIMP-1). The level of MMP-1 in psoriatic scales was also shown to be inversely correlated to the psoriasis severity 30 .…”

“…However, Flisiak et al 30,31 reported that the elevated levels of MMP-1 and TIMP-1 in psoriatic plasma and the levels of MMP-1 and TIMP-1 in psoriatic plasma were inversely correlated to the disease severity (a decrease in MMP-1 and an increase in TIMP-1). The level of MMP-1 in psoriatic scales was also shown to be inversely correlated to the psoriasis severity 30 . Although MMP-2 was shown to be overexpressed in the psoriatic lesions 23,32 , we could only observe the significant elevation of the MMP-2 mRNA level in the lesions of SP psoriasis (and not in LP psoriasis), as compared with the MMP-2 mRNA level in the non-lesional skin.…”