Effect of Prunus dulcis and Salvia hispenica in the management of polycystic ovary syndrome in Wistar rats

Ramachandran, Somasundaram; Nikitha, Jasthi; Gopi, Chandravadivelu; Amala, Masa; Dhanaraju, Magharla Dasaratha

doi:10.1016/j.jtumed.2020.02.002

Cited by 11 publications

(16 citation statements)

References 46 publications

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“…Furthermore, in rats, chia increased blood steroid hormone levels. The differences observed in our experiments and in the experiments of Ramachandran et al (2020) could be explained either by the experimental objects (rats versus pigs and cows) or the experimental models (in vivo and in vitro). Nevertheless, both studies represent the first demonstrations of chia influences on ovarian functions.…”

Section: Discussioncontrasting

confidence: 83%

“…In porcine ovarian cells, it impaired apoptosis (bax) and progesterone release, not affecting PCNA. The observed effects of chia extract on bovine and porcine ovarian cells do not correspond to the chia effects observed in in vivo experiments on rats (Ramachandran et al, 2020). In these experiments, chia increased ovarian weight (which can be a result of ovarian growth associated with increased ovarian cell proliferation).…”

Section: Discussionmentioning

confidence: 61%

“…The search for plants that could be natural protectors of ovarian cells against all or at least the most dangerous effects of xylene could be important from both theoretical and practical viewpoints. The presence of adaptogens in chia (Knez Hrnčič et al, 2019) and its ability to prevent ovarian pathological changes associated with polycystic ovarian syndrome (Ramachandran et al, 2020) indicate that this plant could protect against the adverse effects of xylene on female reproductive processes. Nevertheless, such an ability has not yet been examined.…”

mentioning

confidence: 99%

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Chia (Salvia hispanica L.) can directly suppress basic ovarian cell functions in two farm animal species and protect ovarian cells from the proliferation‐stimulating influence of xylene

Tarko

Štochmaľová

Fabová

et al. 2023

Reprod Domestic Animals

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The influence of the functional food plant chia (Salvia hispanica L.) on reproduction functions and its ability to prevent the negative effects of environmental contaminants has not yet been studied. Our study aimed to examine the effect of chia seed extract alone and in combination with xylene on the markers of proliferation, apoptosis and hormones release by cultured bovine and porcine ovarian granulosa cells. The extract of chia reduced all of the measured parameters in bovine and porcine ovarian cells but had no effect on the proliferation of porcine cells. Xylene, stimulated proliferation and IGF‐I release and inhibited the release of progesterone and testosterone but not apoptosis of bovine granulosa cells. It promoted proliferation, apoptosis and progesterone output by porcine cells. Chia mitigated the stimulatory effect of xylene on proliferation but not on other parameters in both species. The present results are the first demonstration of a direct effect of chia on basic ovarian cell functions. They confirmed a direct influence of xylene on these functions and found a similar stimulatory action of xylene on bovine and porcine ovarian cell proliferation. The present observations demonstrated species‐specific differences in the characteristics of xylene influences on ovarian cell apoptosis and secretory activity. Finally, the present results indicate that chia can be a natural protector against the proliferation‐stimulating effects of xylene on ovarian cells in both species.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 61%

mentioning

confidence: 99%

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Chia (Salvia hispanica L.) can directly suppress basic ovarian cell functions in two farm animal species and protect ovarian cells from the proliferation‐stimulating influence of xylene

Tarko

Štochmaľová

Fabová

et al. 2023

Reprod Domestic Animals

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“…Body weight gain (g) was calculated = Final weight (g) -Initial weight (g) (Ramachandran et al, 2020).…”

Section: Nutrient Intake G Kg Nutrient In Feces G Kg 100 Nutrient Digmentioning

confidence: 99%

Therapeutic potential of hydrolysable tannin on weight management oxidative stress and reproductive health in polycystic rats

et al. 2022

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Phytonutrients get attention now days due to their wide application and their tendency to improve the productive and reproductive performance in humans. Hydrolysable tannin (HT) is one of these bionutrients. The present study was aimed to investigate the therapeutic effect of HT on the induced polycystic ovarian syndrome (PCOS) in rats. Forty-five adult female rats with 4 to 5 days regular estrous cycle were selected. The PCOS was induced by a single intramuscular injection of Estradiol Valerate 4 mg/rat/kg. The rats were offered 0.5, 1, 1.5 and 2% of HT/kg body weight through oral gavage for two months. The results had shown a reduction (p<0.05) in average feed intake, body weight and weight gain, total oxidative stress and nutrient digestibility in PCOS rats. Similar reduction trend (p<0.05) in serum luteinizing hormone and insulin was observed; while serum follicular stimulating hormone, serum prolactin and total antioxidant capacity were improved (p<0.05). The ovarian histopathology showed no signs of reduction in cystic follicles while no improvement was observed in healthy follicles. The study concluded that the treatment with 1.5% level of HT had shown the best therapeutic potential for weight management, reduction of oxidative stress and improvement in reproductive health of PCOS rats.

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“…The animals were acclimatized for laboratory conditions 1 week before conductance of the study to avoid anxiety in animals. All the experimental animals were housed under standard environmental temperature (23 ± 2 o C), humidity (50 ± 5%), and 12 h of light/dark cycles [34]. The husk in the cages was cleaned on every alternate day to ensure hygiene and maximum comfort for animals.…”

Section: Experimental Animalsmentioning

confidence: 99%

Evaluation of bone healing activity of Cissus quadrangularis (Linn), Cryptolepis buchanani, and Sardinella longiceps in Wistar rats

Ramachandran¹,

Fadhil²,

Gopi³

et al. 2021

Beni-Suef Univ J Basic Appl Sci

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Background The object of the present study is to evaluate the effect of alcoholic extracts of Cissus quadrangularis (CQ), Cryptolepis buchanani (CB), and Sardinella longiceps (SL) either alone or in the combination (100 mg/kg) in the management of femur bone healing of Wistar albino rats for 8 weeks. After the period of treatment, femur bones were examined by using biochemical, radiographical, and histopathological studies. Result Biochemical evaluation results reveal that there is a steep increase of serum calcium level in the experimental animals during the entire period of treatment which led to an adequate supply of serum calcium to the fractured bone for healing and increases the thickness of the femur bones soon compared to control group. It had been estimated by a calibrated ocular micrometer. Radiographical images of the bones also disclose that the complete bridging of fractured bone occurred in the experimental animals after the treatment of natural compound extracts. In addition to that, all the organs of animals were safe in the experimental animals during the entire study. Conclusion The present study strongly recommended that these ethanolic extracts (CQCBSL) either alone or in the combination restoring the strength of the bone and reduced bone repairing period due to the rich content of calcium and other natural phytochemicals presents with them. Graphical abstract

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Effect of Prunus dulcis and Salvia hispenica in the management of polycystic ovary syndrome in Wistar rats

Cited by 11 publications

References 46 publications

Chia (Salvia hispanica L.) can directly suppress basic ovarian cell functions in two farm animal species and protect ovarian cells from the proliferation‐stimulating influence of xylene

Chia (Salvia hispanica L.) can directly suppress basic ovarian cell functions in two farm animal species and protect ovarian cells from the proliferation‐stimulating influence of xylene

Therapeutic potential of hydrolysable tannin on weight management oxidative stress and reproductive health in polycystic rats

Evaluation of bone healing activity of Cissus quadrangularis (Linn), Cryptolepis buchanani, and Sardinella longiceps in Wistar rats

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