Effect of prostaglandin A₁ in porcine cells persistently infected with classical swine fever virus

Abstract

Cyclopentenone prostaglandins are potent inhibitors of a wide variety of RNA and DNA viruses. In this report we describe that prostaglandin A1 (PGA1) potently inhibited the replication of classical swine fever virus in cultures of PK-15 cells. The highest non-toxic dose (5 microg/ml) inhibited virus yield in 99% at the initial phase of infection and in 77% in persistent infected cells. However when PGA1 was removed from persistently infected cells, the inhibition of virus replication was partially reverted.

Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus

“…BVDV is the type-species of the Pestivirus genus (from the Flaviviridae family) that also includes the border disease virus (BDV) and the classical swine fever virus (CSFV), responsible for significant economic losses worldwide. 4 The pestivirus capsid has an icosahedral symmetry formed by a single protein (capsid protein C), and is enveloped by a lipoprotein membrane. Its genome consists of a positive sense, single-stranded RNA of about 12,000 nucleotides, containing a large open reading frame coding for a single polyprotein with about 4000 amino acids.…”

Anti-Classical Swine Fever Virus Strategies

“…MG132 [119], a proteasome inhibitor, could attenuate the CSFV replication. (9) Other molecules also have anti-CSFV effects, such as Prostaglandin A1 [120,121], the phage-displayed E2-binding peptides [122], ceramide (C6) (activator of the protein phosphatase 1 pathway) [123], and quercetin (inhibitor of HSP70 function) [88]. More and more anti-CSFV drug candidates will be discovered with the increase of antiviral research.…”