Effect of prostacyclin on antigfn inducfd ifowdiatf rronchoconstriction in astmatic patients

Bianco, S.; Robuschi, M.; Grugni, A.; Ceserani, R.; Gandolfi, C.

doi:10.1016/0161-4630(79)90014-4

Cited by 18 publications

(13 citation statements)

References 7 publications

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“…In contrast, these PGI 2 analogues relax human bronchial preparations (Haye-Legrand et al, 1987). However, the eect of inhaled PGI 2 does not alter airway calibre in normal or asthmatic subjects (Hardy et al, 1985;Bianco et al, 1979). Together, the results obtained in these studies suggest that the subtypes of prostanoid-receptors involved in the relaxation of airway smooth muscle vary between species.…”

Section: Introductionmentioning

confidence: 35%

Prostanoid receptors involved in the relaxation of human bronchial preparations

Norel

Walch

Labat

et al. 1999

British J Pharmacology

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1 Iloprost and cicaprost (IP-receptor agonists) induced relaxations in the histamine-(50 mM) contracted human bronchial preparations (pD 2 values, 6.63+0.12 and 6.86+0.08; E max values, 90+04 and 65+08% of the papaverine response for iloprost (n=6) and cicaprost (n=3), respectively).2 Prostaglandin E 2 (PGE 2 ) and misoprostol (EP-receptor agonist) relaxed the histamine-contracted human bronchial preparations (pD 2 values, 7.13+0.07 and 6.33+0.28; E max values, 67+04 and 57+08% of the papaverine response for PGE 2 (n=14) and misoprostol (n=4), respectively). In addition, both relaxations were inhibited by AH6809 (DP/EP 1 /EP 2 -receptor antagonist; 3 mM; n=5 ± 6). 3 The PGE 2 -induced relaxations of human bronchial preparations were not modi®ed by treatment with AH23848B (TP/EP 4 -receptor antagonist; 30 mM; n=4). 4 The contracted human bronchial preparations were signi®cantly relaxed by prostaglandin D 2 (PGD 2 ) or by BW245C a DP-receptor agonist. However, these responses did not exceed 40% of the relaxation induced by papaverine. In addition, the relaxations induced by PGD 2 were signi®cantly inhibited by treatment with a DP-receptor antagonist BWA868C (0.1 mM; n=3). 5 These data suggest that the relaxation of human isolated bronchial preparations induced by prostanoids involved IP-, EP 2 -and to a lesser extent DP-receptors but not EP 4 -receptor.

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Section: Introductionmentioning

confidence: 35%

Prostanoid receptors involved in the relaxation of human bronchial preparations

Norel

Walch

Labat

et al. 1999

British J Pharmacology

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“…Various observations in asthmatic pa tients again revealed no bronchial dilatory effect of PGD [7,14]. When given by inhal ation, prostacyclin evoked circulatory symptoms similar to those observed fol lowing its intravenous administration.…”

Section: Discussionmentioning

confidence: 73%

Pulmonary and Antiaggregatory Effects of Prostacyclin after Inhalation and Intravenous Infusion

Burghuber¹,

Silberbauer²,

Haber³

et al. 1984

Respiration

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Prostacyclin (PGI₂) was administered by inhalation (50 μg/min) and intravenous infusion (15 ng/kg/min) in 5 healthy male volunteers. Irrespective of the route of administration this substance was shown to have no effects on respiratory indices studied, whereas a significant inhibition of ADP-induced platelet aggregation and a fall in vascular resistance could be demonstrated. Mainly because of the latter action it is suggested that PGI2, or a stable synthetic analogue, might become a potent drug in various pathological conditions, in which hypertension of various causes is a problem.

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“…This effect has been looked for but not seen consistently in patients undergoing cardiopulmonary bypass Longmore et al, 1981;Walker et al, 1981) or charcoal haemoperfusion; this may be because the agent responsible is being destroyed or removed , or because in these circumstances flushing seems too minor an effect to warrant comment. Facial flushing can also occur during haemodialysis with PGI2 (Turney et al, 1980;Zusman et al, 1981b) and has also been seen following inhalation of PGI2 (Bianco et al, 1979;Szczeklik et al, 1978b). Flushing is seen in the affected limb when PGI2 is infused intra-arterially (Machin et al, 1981b).…”

Section: Discussion and Literature Review Flushingmentioning

confidence: 99%

“…As has been found with other vasodilators, arterial P02 may fall with PGI2 (Gimson et al, 1981;Tricot et al, 1980;Williams et al, 1980). When delivered by inhalation, PGI2 can cause pharyngeal irritation and coughing, probably due to the high pH of the inhalate (Bianco et al, 1979;Szczeklik et al, 1978b). Hypotonia was mentioned by and Fidler et al (1981), all in relation to PGI2 infusions.…”

Section: Miscellaneousmentioning

confidence: 93%

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Side effects occurring during administration of epoprostenol (prostacyclin, PGI2), in man.

Pickles¹,

O’Grady²

1982

Brit J Clinical Pharma

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1 Fifty infusions of epoprostenol (PGI2) were made, usually increasing the infusion rate until adverse effects were encountered. The volunteers were appraised that they might experience headache and facial flushing. 2 Facial flushing, headache, tachycardia and decrease in diastolic blood pressure were seen in almost all subjects. Erythema over the venous infusing site was also encountered in 13 infusions. Less common effects were sudden bradycardia, pallor and sweating-the vagal reflex-(seven times) and chest pain (twice). Other complaints included restlessness, abdominal discomfort, nausea and drowsiness.3 The literature on side effects reported during PGI2 infusion is reviewed and recommendations are made concerning administration of PGI2.

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Effect of prostacyclin on antigfn inducfd ifowdiatf rronchoconstriction in astmatic patients

Cited by 18 publications

References 7 publications

Prostanoid receptors involved in the relaxation of human bronchial preparations

Prostanoid receptors involved in the relaxation of human bronchial preparations

Pulmonary and Antiaggregatory Effects of Prostacyclin after Inhalation and Intravenous Infusion

Side effects occurring during administration of epoprostenol (prostacyclin, PGI2), in man.

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