Side effects occurring during administration of epoprostenol (prostacyclin, PGI2), in man.

Pickles, H; O’Grady, John

doi:10.1111/j.1365-2125.1982.tb01959.x

Cited by 69 publications

(21 citation statements)

References 53 publications

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“…Both-the buffer and PGI2 were infused via an indwelling cannula positioned in an antecubital vein, as this appears to reduce the frequency of local venous reactions, which may be because of the high pH of the buffer. 26 No such reaction was observed in the present study. Prostacyclin was administered intravenously to ensure that adequate concentrations of PGI2 were achieved at the serosal border of the enterocyte, where prostanoids act to effect secretion.…”

Section: Systemic Effects Of Prostacyclincontrasting

confidence: 61%

Effect of prostacyclin (PGI2) on water and solute transport in the human jejunum.

Moriarty¹,

O’Grady²,

Rolston³

et al. 1986

Gut

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SUMMARY Prostacyclin is an arachidonic acid metabolite, synthesised throughout the gastrointestinal tract, which has different effects on water and electrolyte transport across a variety of mammalian gastrointestinal epithelia. Using a perfusion technique in the human jejunum of 11 healthy subjects in vivo, the effect of intravenous prostacyclin, 4 ng/kg/min, on jejunal water and solute transport from a glucose electrolyte solution was investigated. In the prostacyclin group (n=5), prostacyclin was infused intravenously from 70-150 minutes, and buffer administered iv from 0-70 and 150-210 minutes. In the buffer group (n=6), iv buffer was administered from 0-210 minutes. In the prostacyclin group, net jejunal absorption of water was inhibited from 90-120 min (p<0 05), 150-180 min (p<0.01) and 180-210 min (p<0O01), of sodium was inhibited from 90-120 min (p<0 05), 120-150 min (p<0-05), 150-180 min (p<0 01) and 180-210 min (p

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Section: Systemic Effects Of Prostacyclincontrasting

confidence: 61%

Effect of prostacyclin (PGI2) on water and solute transport in the human jejunum.

Moriarty¹,

O’Grady²,

Rolston³

et al. 1986

Gut

Self Cite

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“…They gave informed consent to a protocol approved by the local ethical committee. Mean age was 32.5 ±6.1 (SD) years (range [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] with a mean Quetelet index of 22.3 ±2.4 (SD) kg/m2.. The volunteers had to abstain from smoking for twenty-four hours and from caffeine-or alcohol-containing beverages for twelve hours and to refrain from food or liquid intake during the two hours preceding the test.…”

Section: Methodsmentioning

confidence: 99%

Hemodynamic Effects of Prostacyclin Infusions in Healthy Volunteers

Wollersheim

Thien

1988

Angiology

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The selective hemodynamic effects of an intravenous infusion of prostacyclin on skin and on forearm blood flow during increasing doses up to 6 ng.kg.-1 min.-1 were evaluated in 12 healthy volunteers. The highest dose raised total skin blood flow (p = 0.0001) as measured by laser Doppler with a concomitant rise in finger skin temperature (p = 0.02). Capillary perfusion as measured by transcutaneous oxygen monitoring remained relatively unaffected (p = 0.25). Cold-induced vasoconstriction and the recovery thereafter were not influenced. Diastolic blood pressure tended to decrease (p = 0.06), but there was no change in systolic blood pressure, forearm blood flow, and calculated forearm vascular resistance. The authors conclude that prostacyclin may have dissimilar vasoactive potencies in different vascular beds as shown by a pronounced increase in total skin blood flow, owing to vasodilation of shunt vessels, simultaneously with an insignificant change in nutritional skin blood flow and forearm muscle blood flow.

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“…In humans PGI 2 usually produces a fall in blood pressure and a modest tachycardia 29 although rise in blood pressure was reported in 3 out of 110 patients with peripheral vascular disease who had been treated with PGI 2 . 34 We have no explanation for the mechanism of hypertensive action of PGI 2 in patients with stroke.…”

Section: Discussionmentioning

confidence: 99%

Treatment of ischaemic stroke with prostacyclin.

Gryglewski¹,

Nowak²,

Kostka-Trabka³

et al. 1983

Stroke

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ity changes in rhesus monkeys and man using 82 Rb and positron emission tomography. J Comput Assist Tomogr 5: [792][793][794][795][796][797][798][799] 1981 16. Cope FW: Nuclear magnetic resonance evidence using D 2 0 for structured water in muscle and brain. Biophys J 9: 303-319, 1969 17. Ashley DL, Goldstein FH: The application of dextranmagnetite as a relaxation agent in the measurement of erythrocyte water exchange using pulsed nuclear magnetic resonance spectroscopy.

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Side effects occurring during administration of epoprostenol (prostacyclin, PGI2), in man.

Cited by 69 publications

References 53 publications

Effect of prostacyclin (PGI2) on water and solute transport in the human jejunum.

Effect of prostacyclin (PGI2) on water and solute transport in the human jejunum.

Hemodynamic Effects of Prostacyclin Infusions in Healthy Volunteers

Treatment of ischaemic stroke with prostacyclin.

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