Effect of propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials

Shang, Huaping; Bhagavathula, Akshaya Srikanth; Aldhaleei, Wafa Ali; Rahmani, Jamal; Karam, Giorgio; Rinaldi, Giulia; Clark, Cain C. T.; Salehi‐Sahlabadi, Ammar; Yuan, Qian

doi:10.1016/j.jksus.2020.01.003

Cited by 24 publications

(20 citation statements)

References 38 publications

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“…Egyptians, Greeks, and Romans used propolis as a portion of human medication for thousands of years, benefiting from its properties [ 12 ]. Propolis is considered a powerful antioxidant used in the preparation of functional foods and food supplements.…”

Section: Introductionmentioning

confidence: 99%

“…It has gastroprotective, hepatoprotective, immunomodulatory, wound healing, antidiabetic, and antineoplastic functions, owing to propolis’ antioxidant, anti-inflammatory, and antimicrobial properties [ 15 , 16 ]. Propolis inhibits the generation of various inflammatory markers, such as nitric oxide, IL-1 and IL, due to its high flavonoid content [ 12 ]. Propolis’ defensive capacity is brought about from its modulator impact on antioxidant enzymes, suppressing free radicals initiation, and reducing subsequent damage [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Defensive impact of propolis against CCl4 actuated rats' testicular damage

Hashem

2021

J Adv Vet Anim Res

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Objective: The paper’s primary goal is to report the devastating impact of carbon tetrachloride (CCl 4 ) on rat testicular tissue and the possible protecting function of propolis against CCl 4 based on its free radical scavenging and inflammatory relief properties. Materials and Methods: A total of 24 adult male albino rats had been classified into four groups (six rats/group). Rats of group 1 served as control, whereas groups 2–4 received propolis (200 mg/kg/day), CCl 4 (3 ml/kg/day), and propolis/CCl 4 , respectively. After 4 weeks, the collected sera were applied for the estimation of lipid profile and sex hormones. Also, histopathological picture, malondialdehyde, and tumor necrosis factor alpha (TNFα) gene profile was measured in collected testicular tissues. Results: The present information revealed a noteworthy change ( p < 0.05) in lipid profile, decrease in testicular weight, testosterone, antioxidants values along with a prominent increase ( p < 0.05) in estradiol, lipid peroxidation values, and expression of TNFα in rats administrated with CCl 4 compared to control. Moreover, the histopathological profile showed the degeneration of the epithelium. Interestingly, propolis attenuated the destructive effect of CCl 4 on rat testes. Conclusion: The examined dose of propolis reduced oxidation, and inflammatory reactions resulted from CCl 4 exposure and proved that it might have a helpful part in free radicals interceded diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Defensive impact of propolis against CCl4 actuated rats' testicular damage

Hashem

2021

J Adv Vet Anim Res

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“…The correlation of lowered adiponectin and increased pro-inflammatory cytokine level was observed in MetS patients [180]. Propolis supplementation was efficacious in reducing various pro-inflammatory cytokines in chronic inflammation and MetS, namely, C-reactive protein (CRP), TNF-α, and IL-6 in human clinical trials [181,182].…”

Section: Discussionmentioning

confidence: 99%

Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

et al. 2021

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Propolis is a resinous product collected by bees from plants to protect and maintain the homeostasis of their hives. Propolis has been used therapeutically by humans for centuries. This review article attempts to analyze the potential use of propolis in metabolic syndrome (MetS) and its associated chronic diseases. MetS and its chronic diseases were shown to be involved in at least seven out of the top 10 causes of death in 2019. Patients with MetS are also at a heightened risk of severe morbidity and mortality in the present COVID-19 pandemic. Propolis with its antioxidant and anti-inflammatory properties is potentially useful in ameliorating the symptoms of MetS and its associated chronic diseases. The aim of this article is to provide a comprehensive review on propolis and its therapeutic benefit in MetS and its chronic diseases, with an emphasis on in vitro and in vivo studies, as well as human clinical trials. Moreover, the molecular and biochemical mechanisms of action of propolis are also discussed. Propolis inhibits the development and manifestation of MetS and its chronic diseases by inhibiting of the expression and interaction of advanced glycation end products (AGEs) and their receptors (RAGEs), inhibiting pro-inflammatory signaling cascades, and promoting the cellular antioxidant systems.

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“…Taken together, a recent meta‐analysis revealed a significant reduction in IL‐6, TNF‐α, and high‐sensitivity C‐reactive protein (hs‐CRP) concentrations by 17.96 pg/ml, 34.08 pg/ml, and 1.16 pg/ml, respectively, following propolis supplementation. Nonetheless, no significant reduction was reported in IL‐1β concentrations with propolis consumption (Shang et al., 2020). Recent scientific evidence (in vitro and in vivo) shows that propolis and its bioactive compounds attenuate inflammatory cytokines synthesis and leukocyte recruitment into the inflammatory site through various mechanisms of action such as blocking the activation of NF‐κB, extracellular signal‐regulated kinase (ERK), and Jun N‐terminal Kinase (JNK) signaling pathways, inhibiting the release of CXCL1/KC and CXCL2/MIP‐2 chemokines, and suppressing the expression of ICAM‐1, vascular cell adhesion molecule 1 (VCAM‐1), and E‐selectin (Franchin et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Effect of propolis supplementation on athletic performance, body composition, inflammation, and oxidative stress following intense exercise: A triple‐blind randomized clinical trial

Soleimani

Miryan

Hadi

et al. 2021

Food Science & Nutrition

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Background Emerging evidence indicates that propolis as a novel potential antioxidant has unique benefits. This study aimed to evaluate the effect of propolis on oxidative stress, inflammation, body composition, and athletic performance in healthy active subjects. Methods This clinical trial was conducted on 54 male military cadets. Eligible subjects were randomly allocated to receive a single dose of 450 mg propolis twice daily for four weeks or a matching placebo containing microcrystalline cellulose. Cooper 12‐min run test and running‐based anaerobic sprint test were performed to measure aerobic and anaerobic performance. Blood samples were obtained immediately after Cooper's test to evaluate oxidative stress and inflammation status. Fat mass and fat‐free mass were analyzed using bioelectrical impedance. Results Mean changes in fat mass, fat‐free mass, anaerobic powers, fatigue index, and VO2 max did not differ significantly between the two groups after the adjustment for baseline values (P‐value>0.05). A significant change was observed in plasma levels of IL‐6 (−1.43 ± 0.11pg/mL), total oxidant status (−3.9 ± 0.2µmol/L), total antioxidant capacity (164 ± 12 µmol/L), malondialdehyde (−0.52 ± 0.03µmol/L), oxidative stress index (−0.45 ± 0.04), and glutathione (48.72±2µmol/L) in the propolis group compared with the placebo group after the adjustment for baseline values and weight changes (P‐value<0.05). Although IL‐10 concentrations had no significant changes in both groups, the ratio of IL‐6/IL‐10 significantly reduced in the propolis group compared with the placebo group (−0.174 ± 0.015 versus. 0.051 ± 0.014; P‐value: 0.041). Conclusions Our results indicated that propolis might have beneficial effects on oxidative stress and inflammation following intense activities in healthy male subjects.

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Effect of propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials

Cited by 24 publications

References 38 publications

Defensive impact of propolis against CCl4 actuated rats' testicular damage

Defensive impact of propolis against CCl4 actuated rats' testicular damage

Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

Effect of propolis supplementation on athletic performance, body composition, inflammation, and oxidative stress following intense exercise: A triple‐blind randomized clinical trial

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