Effect of propionyl-l-carnitine, l-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes

Abstract

Although there was a small number of subjects in this study the data suggest that the test formulation may improve the endothelial situation in diabetes. The test formulation together with vardenafil was better than the 5PDE inhibitor alone, but further studies are needed to confirm these findings.

Hyperhomocysteinaemia in rats is associated with erectile dysfunction by impairing endothelial nitric oxide synthase activity

“…Phosphodiesterase type 5 inhibitors, a pharmaceutical agent with anti-oxidant properties, are the first-line treatment option for ED, although the efficacy is lower compared to the general ED population284647. Numerous prospective studies have reported that patients with ED who have long-term intake of folic acid and vitamin B 12 can reduce the blood concentration of HCy and delay the onset of HHCy263148.…”

Carnitine derivatives

“…Clinical trials demonstrate that PLC enhances the international index of erectile function scores in diabetic patients treated with sildefanil or verdenafil [92][93][94]. In a preliminary report, Gasbarrini et al [95] have investigated the effects of PLC topical irrigation in distal ulcerative colitis and reported significant improvements in histological features.…”

Nonresponse to PDE5 inhibitors in erectile dysfunction. Part 2

“…Other combinations that have been shown to salvage PDE5-Is nonresponders include PDE5-Is and either propionyl L-carnitine [86,87], vitamin E [88], melanocortin receptor agonist [89], losartan [90], pioglitazone [91], quinapril and atorvastatin [92], pentoxifylline [93], vitamin B6, and folic acid [94], or continuous positive airway pressure [95].…”