Carnitine derivatives

Malaguarnera, Mariano

doi:10.1097/mog.0b013e3283505a3b

Cited by 86 publications

(36 citation statements)

References 89 publications

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“…Brain acyl-carnitines can function in synthesizing lipids, altering and stabilizing membrane composition, improving mitochondrial function, increasing antioxidant activity, and enhancing cholinergic neurotransmission [32]. A decreased activity of CAT has been measured in temporal cortex of AD patients [33] (and in our analysis as well - Figure 2), and it has been demonstrated that acetyl-carnitine administration can improve the cognitive performance in patients with mild AD [34].…”

Section: Resultssupporting

confidence: 64%

Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer's Disease

2014

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Accumulating evidence links numerous abnormalities in cerebral metabolism with the progression of Alzheimer's disease (AD), beginning in its early stages. Here, we integrate transcriptomic data from AD patients with a genome-scale computational human metabolic model to characterize the altered metabolism in AD, and employ state-of-the-art metabolic modelling methods to predict metabolic biomarkers and drug targets in AD. The metabolic descriptions derived are first tested and validated on a large scale versus existing AD proteomics and metabolomics data. Our analysis shows a significant decrease in the activity of several key metabolic pathways, including the carnitine shuttle, folate metabolism and mitochondrial transport. We predict several metabolic biomarkers of AD progression in the blood and the CSF, including succinate and prostaglandin D2. Vitamin D and steroid metabolism pathways are enriched with predicted drug targets that could mitigate the metabolic alterations observed. Taken together, this study provides the first network wide view of the metabolic alterations associated with AD progression. Most importantly, it offers a cohort of new metabolic leads for the diagnosis of AD and its treatment.

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Section: Resultssupporting

confidence: 64%

Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer's Disease

2014

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“…Although most of colorectal patient were able to work, lower levels of productivity, lower work ability and reduced job retention have been reported. An adequate supportive therapy of fatigue [22][23][24] could increase work productivity and health-related quality of life. Future studies are needed to investigate the relation among job, cancer, and related cancer treatment, and develop innovative approaches at the workplace to address these areas realistically and head on.…”

Section: Discussionmentioning

confidence: 99%

Work Productivity and Activity Impairment in Colorectal Cancer Patients Treated with Capecitabine

Malaguarnera¹,

Pennisi²,

Grosso³

et al. 2013

JCT

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Background: The employment status of workers with cancer has important implications for impairment of intimate and family relationships and for economic, social and psychological health. The aim of the present study was to evaluate the effect of chemotherapy with capecitabine in patients with colorectal cancer on work productivity and daily activity. Methods: 30 patients with primary diagnosis of stage III colorectal cancer were enrolled for our study. All patients received capecitabine twice daily at a cumulative dose of 2500 mg/m 2 on days 1 -14 and repeated on day 22. Work productivity was determined using the WPAI questionnaire. Results: We observed a significant increase in absenteeism after 1 cycle, after 6 cycles of therapy and at follow-up (p < 0.001). On the other hand, presenteeism, work productivity loss and daily activity impairment, increased after 1 cycle and 6 cycles of therapy, but we could not find statistically different significances. Conclusions: Colorectal cancer diagnosis and treatment are associated with frailty and vulnerability. Chemotherapy with capecitabine may result in negative consequences for job performance.

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“…Carnitine is synthesized from the essential aminoacids lysine and methionine in kidney, liver and brain (7). L-carnitine, acetyl-L-carnitine and various carnitine enzymes play a relevant role in cellular energy production (8) being involved in the carriage of long-chain fatty acids into the mitochondrial matrix for beta oxidation (9). Previous studies showed that carnitine and its derivatives reduce depression, both physical and mental fatigue, improves cognitive functions and quality of life (10, 11).…”

Section: Introductionmentioning

confidence: 99%

Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α2b Plus Ribavirin: Effect on Work Performance. A Randomized Clinical Trial

et al. 2014

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Background:The health status of employees with chronic hepatitis C has major implications for organizations and labour market.Objectives:To assess the effects of Acetyl-L-Carnitine administration on work productivity, daily activity, and fatigue in subjects with chronic hepatitis C treated with Pegylated-Interferon-α2b and Ribavirin.Patients and Methods:In this prospective, randomized, placebo controlled, double blind clinical trial, 30 subjects (Group A) with chronic hepatitis, received Pegylated-Interferon-α2b (1.5 mg/kg per week) plus Ribavirin and placebo, while 32 subjects (Group B) received the same dosage of Pegylated-Interferon-α2b plus Ribavirin plus 2g Acetyl-L-Carnitine twice per day, for 12 months. Work productivity loss, impairment in daily activities, presenteeism, absenteeism, have been assessed using the Work Productivity and Activity Impairment questionnaire. We also evaluated severity of fatigue, mental fatigue and physical fatigue.Results:Significant difference were observed in physical fatigue, mental fatigue and severity of fatigue, aspartate aminotransferase, alanine aminotransferase, and viremia after 12 months treatment. In Group B we observed a significant decrease of presenteeism and daily activity impairment after 6 months, 12 months and at follow up. A significant increase of work productivity was observed after 12 months and at follow up.Conclusions:Office workers with chronic hepatitis C, treated with Pegylated-Interferon-α2b plus Ribavirin, had work performance loss. In subjects treated with Acetyl-L-Carnitine supplementation we observed increased daily activity and reduced presenteeism and fatigue. Acetyl-L-Carnitinegroup had a smaller reduction of productivity comparing to placebo group.

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Carnitine derivatives

Abstract: A number of therapeutic effects possibly come from the interaction of carnitine and its derivatives with the elements of cellular membranes.

Cited by 86 publications

References 89 publications

Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer's Disease

Integrating Transcriptomics with Metabolic Modeling Predicts Biomarkers and Drug Targets for Alzheimer's Disease

Work Productivity and Activity Impairment in Colorectal Cancer Patients Treated with Capecitabine

Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α2b Plus Ribavirin: Effect on Work Performance. A Randomized Clinical Trial

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