Effect of Proparacaine on Tropicamide-Induced Mydriasis

The Mydriatic Effect of Multiple Doses of Tropicamide

“…The error bars represent Ϯ1 standard deviation. Consistent with previous studies 8, 15 and irrespective of the drug condition, pupil diameter increases gradually as a function of time from the instillation of tropicamide, reaches a peak pupil diameter, and remains approximately constant or decreases slightly up to the last recorded measurement at 60 minutes.…”

Effects on Pupil Size and Accommodation from Topical Lidocaine Hydrochloride and Tetracaine Hydrochloride

“…6,10,[15][16][17] In a study by Siderov and colleagues, potentiation of tropicamide mydriasis from topical local anesthetics could be seen only in subjects with pale irides. 11 In pigmented irides, we noted a slight pupil constriction from the anesthetic eye drops in the present material. We in our study used standard, unbuffered anesthetic solutions with low pH:s, and the paradoxal miosis in pigmented irides may be due to unspecific irritation of the eye from the low pH of the eye drops, causing an irritative miosis.…”

“…At 60 and 120 min, the BSCVA was also determined. Since large differences in mydriatic response have been reported depending on iris pigmentation, 10,11 we decided to perform a subgroup analysis of the material based on iris pigmentation. The iris color of each subject was recorded as either "pale" (blue eyes; n ϭ 17) or "pigmented" (green/brown eyes; n ϭ 9).…”

Evaluating the Potentiating Effect of Amethocaine on Tropicamide-Induced Mydriasis in Darkly Pigmented Irides, Using Infrared Pupillometry

“…Darkly pigmented irides do not dilate as fast or as well as light-colored irides. However, there have been studies suggesting that prior instillation of an anesthetic like amethocaine may enhance the adrenergic iris dilator muscle response to a mydriatic-like tropicamide, by increasing its corneal penetration and hence its bioavailability 1,2. Achieving adequate mydriasis has diagnostic and therapeutic implications; for instance, the visualization of the retinal periphery for the staging or diagnosis of retinal disorders such as retinopathy of prematurity3 retinoblastomas,4 or the laser treatment of retinal tumors as indicated in transpupillary thermotherapy5 and for surgical procedures 6.…”