Effect of Prolactin on Excretory Function of the Liver during the Induction and Relief of Cholestasis in Female Rats

Kushnareva, N. S.; Смирнова, О. В.

doi:10.1007/s10517-010-0810-x

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…It can be hypothesized that intoxication in the kidney decreases in cholestasis of pregnancy model because of the decrease of mrp2 expression in the renal medulla. This can explain the increase in blood bilirubin concentration previously observed in this model [4] that increases the risk of metabolic intoxication for other organs. All these changes can aggravate the course of cholestasis of pregnancy.…”

Section: Resultssupporting

confidence: 70%

Expression of Multidrug Resistance Protein 2 (mrp2) in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy

2015

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Using immunohistochemical method with semiquantitative analysis of images, we showed that mrp2 expression in response to cholestasis decreased in hepatocytes and cholangiocytes, and remained unchanged in the kidney structures. A decrease of mrp2 expression in renal tubules leading to a decrease of metabolic intoxication of the kidney was demonstrated in cholestasis of pregnancy model. In bile ducts cells, negative correlations of mrp2 with previously measured levels of prolactin receptors, CFTR, and mrp3 were revealed. In renal structures and in hepatocytes, no correlations were found between the expression of these proteins. We hypothesize that prolactin produces a direct effect on mrp2 expression in bile ducts cells mediated by prolactin receptors in cholangiocytes. The absence of correlations between mrp2 and the above-mentioned proteins in hepatocytes and renal structures is most likely related to prolactin effects on other systemic regulators.

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Section: Resultssupporting

confidence: 70%

Expression of Multidrug Resistance Protein 2 (mrp2) in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy

2015

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“…Presumably, differences in prolactin concentration in animals of different genders with OC are closely associated with the appearance of genderrelated differences in redistribution of bilirubin pools. This hypothesis is supported by the fact revealed in our study: the infl uence of prolactin on bilirubin level in the bile and the bile excretory function of the liver in female rats increases in OC [2].…”

supporting

confidence: 85%

Changes in Gender-Related Redistribution of Bilirubin Pools in Hyperprolactinemic Rats during Induction and Relieving of Cholestasis

Kushnareva

Смирнова

2010

Bull Exp Biol Med

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“…Chronic liver injury caused by cholestasis may lead to anoxic areas in the liver that may induce HIF-1α activation, which further regulates a variety of fibrotic mediators, and stimulates the overproduction of collagen and liver fibrosis [64][65][66]. In the cholestasis of pregnancy, prolactin and its receptors are involved in water-salt metabolism and in turn, affect liver bile excretion [67][68][69]. Relaxin has natural anti-fibrosis activity in many organs, which can weaken the fibrosis characteristics of activated HSCs and reverse the formation of liver fibrosis [70][71][72].…”

Section: Discussionmentioning

confidence: 99%

Exploration of the Molecular Basis of Forsythia Fruit in the Prevention and Treatment of Cholestatic Liver Injury through Network Pharmacology and Molecular Docking

Dai

et al. 2023

Nutrients

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Forsythia fruit, edible fruit of Forsythia suspensa (Thunb.) Vahl, which has been found to be effective in treating cholestasis. However, its key component for alleviating cholestasis has not been determined. In this study, four representative active ingredients in forsythia fruit were selected. Through network pharmacology and molecular docking technology, we tried to find the key component for its treatment of cholestasis. Furthermore, the model of cholestasis in mice was established to verify the protective effect of the key component on cholestasis. Network pharmacology and molecular docking showed that forsythoside A (FTA) is the key component of forsythia fruit in the treatment of cholestasis. In vivo experiments revealed that FTA treatment could alleviate liver injury, dysfunction, and collagen deposition induced by cholestasis in mice. At the same time, FTA treatment inhibited inflammatory factor release and fibrosis-related factor expression. In addition, FTA treatment also reduced MMP-2, TLR4, MYD88, NF-κB p65, and p-NF-κB p65 protein expression. In conclusion, FTA, a key component of forsythia fruit, alleviated liver damage and fibrosis caused by cholestasis via inhibiting the TLR4/NF-κB pathway, extracellular matrix accumulation, and inflammatory cytokine expression. The research results could provide a scientific reference for the development of forsythia fruit as a drug or functional food to prevent and treat cholestasis.

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Effect of Prolactin on Excretory Function of the Liver during the Induction and Relief of Cholestasis in Female Rats

Cited by 4 publications

References 13 publications

Expression of Multidrug Resistance Protein 2 (mrp2) in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy

Expression of Multidrug Resistance Protein 2 (mrp2) in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy

Changes in Gender-Related Redistribution of Bilirubin Pools in Hyperprolactinemic Rats during Induction and Relieving of Cholestasis

Exploration of the Molecular Basis of Forsythia Fruit in the Prevention and Treatment of Cholestatic Liver Injury through Network Pharmacology and Molecular Docking

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