Changes in Gender-Related Redistribution of Bilirubin Pools in Hyperprolactinemic Rats during Induction and Relieving of Cholestasis

Kushnareva, N. S.; Смирнова, О. В.

doi:10.1007/s10517-010-0993-1

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…These processes are followed by abnormal bilirubin release into the blood. Our previous experiments showed that prolactin does not obstruct bile outfl ow under these conditions [1]. The positive correlation between the manifestation level of mrp3 and the number of prolactin receptors in cholangiocytes of experimental animals suggests that prolactin can have a direct effects on cholangiocytes.…”

Section: Resultsmentioning

confidence: 84%

“…Our previous results indicated that hyperprolactinemia aggravated the course of cholestasis due to additional elevation of bilirubin concentration in the blood [1]. It can be proposed that this effect of prolactin is related to disturbances in the functions of the kidney rather than the liver.…”

Section: Resultsmentioning

confidence: 96%

“…Our previous results suggest that hyperprolactinemia causes an additional increase in blood bilirubin concentration in female rats with cholestasis [1]. This could be related to changes in mrp3 manifestation in the liver and/or kidney cells.…”

mentioning

confidence: 87%

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Manifestation of Multidrug Resistance Protein 3 (MRP3) in Liver and Kidney Cells in Cholestasis: Effects of Hyperprolactinemia

2013

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Immunohistochemistry with semiquantitative image analysis showed that cholestasis induced an increase in the manifestation of mrp3 in cholangiocytes of female rats, but did not affect this parameter in the studied structures of kidney. Under conditions of normal liver function, mrp3 expression in cholangiocytes was also elevated during hyperprolactinemia. Expression of mrp3 in cholangiocytes directly correlated with prolactin receptor expression. In cholestasis, prolactin increased mrp3 manifestation of only in the distal renal tubules. Thus, mrp3 manifestation increases in liver cells, but remains unchanged in kidney cells. The hyperprolactinemia-induced changes in the mrp3 levels and their correlations with prolactin receptor expression were shown to differ in the kidney and liver cells. It was hypothesized that prolactin produced a direct effect on mrp3 expression in cholangiocytes.

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Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 96%

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Manifestation of Multidrug Resistance Protein 3 (MRP3) in Liver and Kidney Cells in Cholestasis: Effects of Hyperprolactinemia

2013

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Relationship between the Expression of VEGF Signal Components and Matrix Metalloproteinases in Ovarian Tumors

Kushlinsky

Левкина

et al. 2011

Bull Exp Biol Med

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The content of vascular endothelium growth factor is significantly increased, while the level of matrix metalloproteinase-2 is 2-fold reduced in ovarian cancer tissue compared to benign tumors. A trend to an increase in the levels of matrix metalloproteinases 7 and 9 and reduction of vascular endothelial growth factor type 2 receptors in tumor tissue was also detected. A highly significant negative correlation between the levels of vascular endothelial growth factor and matrix metalloproteinase 2 and positive correlations between vascular endothelial growth factor and matrix metalloproteinase 7, vascular endothelial growth factor and matrix metalloproteinase 9, matrix metalloproteinase 2 and vascular endothelial growth factor type 2 receptors were revealed. In the tumors assayed after preoperative therapy, relative normalization of the studied parameters was observed: the level of vascular endothelial growth factor decreased significantly, while the levels of matrix metalloproteinase 2 and vascular endothelial growth factor type 2 receptors increased. The levels of the markers differed significantly in ovarian tumors of different histological types, and the levels of vascular endothelial growth factor type 2 receptors were higher in patients with stage III compared to stage I and the content of matrix metalloproteinase 7 was higher in stage III compared to stage II cancer.

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Changes in Gender-Related Redistribution of Bilirubin Pools in Hyperprolactinemic Rats during Induction and Relieving of Cholestasis

Cited by 2 publications

References 12 publications

Manifestation of Multidrug Resistance Protein 3 (MRP3) in Liver and Kidney Cells in Cholestasis: Effects of Hyperprolactinemia

Manifestation of Multidrug Resistance Protein 3 (MRP3) in Liver and Kidney Cells in Cholestasis: Effects of Hyperprolactinemia

Relationship between the Expression of VEGF Signal Components and Matrix Metalloproteinases in Ovarian Tumors

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