Effect of probiotics in the treatment of acute noninflammatory diarrhea in hospitalized children aged 2–10 years

Khoshdel, Abolfazl; Kasiri, Karamali; Salehi, Simin; Sedehi, Morteza

doi:10.4103/jphi.jphi_5_19

Cited by 4 publications

(3 citation statements)

References 26 publications

(32 reference statements)

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“…Detailed characteristics of the included RCTs are presented in Table S2 , and excluded trials are shown in Table S3 . Ultimately, 15 RCTs that randomized 1765 participants (895 in the experimental group and 870 in the control group) were included [ 10 , 11 , 12 , 16 , 17 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, caution is needed when interpreting these results, as two included studies [ 20 , 22 ] did not report the dose of each probiotic strain in the intervention; besides this dose issue, the course of acute gastroenteritis could also affect the efficacy of the probiotic. We think this is the most comprehensive analysis of this probiotic strain that has been conducted to date, and we hope that our findings will be especially useful to decision-makers.…”

Section: Discussionmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis: Lactobacillus acidophilus for Treating Acute Gastroenteritis in Children

Cheng

Liu

et al. 2022

Nutrients

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The efficacy of probiotic strains of Lactobacillus acidophilus to manage acute gastroenteritis in children is still not established. We searched the Cochrane Library, PubMed, EMBASE, and three Chinese literature databases (CNKI, WanFang, and CBM) from their inception to February 2021 for RCTs that compared the use of Lactobacillus acidophilus with no Lactobacillus acidophilus. The grey literature was searched through Google Scholar. Authors of the original papers were contacted for additional data. The study included a total of 15 RCTs involving 1765 patients. Compared with placebo or no treatment, Lactobacillus acidophilus was associated with a reduced duration of diarrhea (moderate quality of evidence), but the effect was not statistically significant when only the individual probiotic strain was provided. Lactobacillus acidophilus was effective when used at a daily dose ≥ 109 CFU. There was no difference in the effect of Lactobacillus acidophilus on diarrhea duration among Asian, European, or American countries. Lactobacillus acidophilus reduced the frequency of diarrhea on day 2 to day 5. However, it was statistically significant on day 3. When administered at a dosage of more than 109 CFU to children with acute gastroenteritis, moderate- to low-quality data showed that Lactobacillus acidophilus reduced the duration of diarrhea and conferred a benefit for frequency of diarrhea.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis: Lactobacillus acidophilus for Treating Acute Gastroenteritis in Children

Cheng

Liu

et al. 2022

Nutrients

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“…Bakteri yang digunakan yaitu Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, B.infantis, Bifidobacterium brevis, dan Streptococcus thermophilus. Rerata frekuensi diare pada hari ke-2 dan ke-4 ,durasi demam, durasi diare, dan lama rawat inap secara signifikan lebih rendah pada kelompok probiotik (Khoshdel et al, 2018). Dosis probiotik yang digunakan adalah 2 kali sehari ½ sachet untuk usia 0-6 bulan dan 2 kali sehari 1 sachet untuk usia diatas 6 bulan.…”

Section: Kombinasi Multi Bakteri Probiotikunclassified

Efektifitas Probiotik Yogurt terhadap Kejadian Diare pada Anak Usia Pra-Sekolah

Arif,

Mardhiyah,

Mediani

2023

J. Obs. J. Pendidik. Anak Usia Dini

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Diare merupakan penyakit kedua terbanyak pada anak. Sebagian besar pengobatan diare hanya berfokus pada mengatasi dehidrasi, namun untuk mengurangi frekuensi diare belum jelas. Maka salah satu terapi komplementer adalah dengan menggunakan probiotik yoghurt. Tujuan review ini mengevaluasi efektivitas yoghurt probiotik pada anak dengan diare akut. Penelitian ini menggunakan metode systematic review, menggunakan 4 database: PubMed, CINAHL, EBSCO dan ScienceDirect. Sampel penelitian adalah pasien anak usia di bawah 12 tahun mengalami diare akut, intervensi yang diberikan berupa Pemberian strain bakteri probiotik dan pemberian yogurt serta artikel ditulis dalam Bahasa Inggris dan full text. Hasil pencarian literatur ditentukan 10 artikel. Ditemukan 8 artikel yang menyatakan bahwa pemberian bakteri probiotik dan yoghurt yang mengandung probiotik dan yoghurt plain (non-probiotik) mampu menurunkan frekuensi, durasi dan pencegahan diare pada anak. Kesimpulan penelitian ini menemukan penggunaan probiotik dengan jenis kombinasi multi strain probiotik, maupun single probiotik dengan dosis tertentu terutama bakteri Saccharomyces boulardii dan Lactobaclus rhamnosus dapat membantu mengurangi frekuensi dan durasi diare.

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Probiotics for treating acute infectious diarrhoea

Collinson

Deans²,

Padua-Zamora

et al. 2020

Cochrane Database of Systematic Reviews

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Background Probiotics may be effective in reducing the duration of acute infectious diarrhoea. Objectives To assess the effects of probiotics in proven or presumed acute infectious diarrhoea. Search methods We searched the trials register of the Cochrane Infectious Diseases Group, MEDLINE, and Embase from inception to 17 December 2019, as well as the Cochrane Controlled Trials Register (Issue 12, 2019), in the Cochrane Library, and reference lists from studies and reviews. We included additional studies identified during external review. Selection criteria Randomized controlled trials comparing a specified probiotic agent with a placebo or no probiotic in people with acute diarrhoea that is proven or presumed to be caused by an infectious agent. Data collection and analysis Two review authors independently applied inclusion criteria, assessed risk of bias, and extracted data. Primary outcomes were measures of diarrhoea duration (diarrhoea lasting ≥ 48 hours; duration of diarrhoea). Secondary outcomes were number of people hospitalized in community studies, duration of hospitalization in inpatient studies, diarrhoea lasting ≥ 14 days, and adverse events. Main results We included 82 studies with a total of 12,127 participants. These studies included 11,526 children (age < 18 years) and 412 adults (three studies recruited 189 adults and children but did not specify numbers in each age group). No cluster‐randomized trials were included. Studies varied in the definitions used for "acute diarrhoea" and "end of the diarrhoeal illness" and in the probiotic(s) tested. A total of 53 trials were undertaken in countries where both child and adult mortality was low or very low, and 26 where either child or adult mortality was high. Risk of bias was high or unclear in many studies, and there was marked statistical heterogeneity when findings for the primary outcomes were pooled in meta‐analysis. Effect size was similar in the sensitivity analysis and marked heterogeneity persisted. Publication bias was demonstrated from funnel plots for the main outcomes. In our main analysis of the primary outcomes in studies at low risk for all indices of risk of bias, no difference was detected between probiotic and control groups for the risk of diarrhoea lasting ≥ 48 hours (risk ratio (RR) 1.00, 95% confidence interval (CI) 0.91 to 1.09; 2 trials, 1770 participants; moderate‐certainty evidence); or for duration of diarrhoea (mean difference (MD) 8.64 hours shorter, 95% CI 29.4 hours shorter to 12.1 hours longer; 6 trials, 3058 participants; very low‐certainty evidence). Effect size was similar and marked heterogeneity persisted in pre‐specified subgroup analyses of the primary outcomes that included all studies. These included analyses limited to the probiotics Lactobacillus rhamnosus GG and ...

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Effect of probiotics in the treatment of acute noninflammatory diarrhea in hospitalized children aged 2–10 years

Cited by 4 publications

References 26 publications

A Systematic Review and Meta-Analysis: Lactobacillus acidophilus for Treating Acute Gastroenteritis in Children

A Systematic Review and Meta-Analysis: Lactobacillus acidophilus for Treating Acute Gastroenteritis in Children

Efektifitas Probiotik Yogurt terhadap Kejadian Diare pada Anak Usia Pra-Sekolah

Probiotics for treating acute infectious diarrhoea

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