Effect of probiotic supplementation on oxidative stress markers in rats with diclofenac-induced hepatotoxicity

Riane, Karima; Sifour, Mohamed; Ouled-Haddar, Houria; Espinosa, Cristóbal; Esteban, M. Ángeles; Lahouel, Mesbah

doi:10.1007/s42770-020-00302-4

Cited by 13 publications

(6 citation statements)

References 21 publications

(27 reference statements)

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“…The level of malondialdehyde (MDA) as an indicator of lipid peroxidation was evaluated using the thiobarbituric acid-reacting substances method (Riane et al, 2020). Briefly, the homogenized tissue sample was incubated with a thiobarbituric acid reagent for 30 min at 95 C. After cooling, it was centrifuged at 1500 × g for 10 min.…”

Section: Evaluation Of the Liver Oxidative Stressmentioning

confidence: 99%

Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma

Hooshmand

Mahdinezhad

Jamshidi

et al. 2021

Phytotherapy Research

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Morus nigra is a rich source of anthocyanins, phytochemicals that have anticancer effects.This study aimed to investigate the effects of M. nigra extract (MNE) on diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC). Male Sprague-Dawley rats were assigned into four groups (n = 10): control, DEN, and DEN +100 or 400 mg/kg of MNE. After 4 months, the DEN group showed a significant mortality rate, hepatic lipid peroxidation, dysplastic nodules in the cirrhotic liver, and an increase of blood bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Also, the body weight gain, blood albumin and glucose, liver antioxidant capacity (thiol groups), and some hematological parameters (RBC, hematocrit, hemoglobin, and platelet) were significantly decreased in the DEN group. MNE significantly increased survival, reduced the size of HCC nodules, improved liver oxidant/antioxidant status, and prevented the above-mentioned changes in the blood (except ALP, glucose, and platelet). Quantitative real-time PCR showed that MNE decreased the expression of Wnt4 and β-catenin, while had no significant effect on PI3K, Akt, and PTEN expression.The MNE did not exhibit antiproliferative activity against HepG2 liver cancer cells. In conclusion, MNE exhibits a hepatoprotective effect through inhibiting oxidative stress and Wnt4/β-catenin pathway and therefore prolongs the survival of rats with HCC.

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Section: Evaluation Of the Liver Oxidative Stressmentioning

confidence: 99%

Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma

Hooshmand

Mahdinezhad

Jamshidi

et al. 2021

Phytotherapy Research

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“…[ 37 ] ALP levels increase during cellular damage, and this toxic effect can be induced by mitochondrial permeability transition and oxidative stress. [ 38 ] In this study, a significant increase in ALP level was observed in the BPA‐treated larvae group. Previous research has found that the BPA‐treated zebrafish embryo showed an increase in oxidative stress and ALP during the early embryonic stage.…”

Section: Discussionmentioning

confidence: 55%

Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine‐rich protein 2

Guru

Arockiaraj

2022

J Biochem & Molecular Tox

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Humans are exposed to obesity causing Bisphenol A in various ways, especially through diet and food containers. Bioactive peptides are already reported to have antioxidant, antidiabetic, and antiobesity properties, which can mimic the role of mediators involved in obesity prevention. The protective effect of a short molecule or peptide, WL15 from cysteine and glycine‐rich protein 2 of a teleost of aquatic resource on Bisphenol A (BPA)‐induced lipid accumulation in zebrafish larvae was investigated. BPA exposure disrupted the antioxidant enzymes, apoptosis, and nitric oxide and led to changes in biochemical markers including alkaline phosphatase, lactate dehydrogenase, lipid peroxidation, glutathione S‐transferases, glutathione peroxidase, and reduced glutathione. However, WL15 inhibited the overproduction of oxidative stress, which correlates with its lipid‐lowering potential. BPA‐induced lipid accumulation in zebrafish showed an increase in triglyceride, cholesterol, and glucose level; simultaneously, WL15 treatment significantly reduced such accumulation in zebrafish. Evidenced by Oil red O staining and Nile red assay, WL15 inhibited lipid accumulation. At the same time, WL15 at 50 µM increases 2‐(N‐[7‐nitrobenz‐2‐oxa‐1,3‐diazol‐4‐yl]amino)‐2‐deoxy‐d‐glucose (2NBDG) glucose uptake in zebrafish. In addition, gene expression studies in zebrafish larvae demonstrated that the WL15 peptide could play a crucial role in preventing lipid accumulation by downregulating the expression of lipogenesis‐specific genes. These results revealed an interesting and novel property of WL15, suggesting its potential application in preventing lipid accumulation through the hypolipidemic and antioxidant properties.

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“…And almost same results were observed in study by Tang et al, in neonatal rats. 13,14 Riane K et al 15 through his investigation has showed the effect of probiotics supplementation on oxidative stress markers in rats with diclofenac hepatotoxicity. Mice after treating with probiotic (Streptococcus salivarius) of concentration 10 9 CFU for seven successive days and then single treatment of diclofenac overdose with distilled water was given.…”

Section: Reducing the Oxidative Stressmentioning

confidence: 99%

“…On investigating the liver transaminases, histology, MDA (malondialdehyde) and GSH (glutathione), it shows that the pretreatment of mice with probiotics has reduced the diclofenac induced hepatotoxicity by enhancing hepatic markers, regulation of antioxidant expressions and their activities. 15 A study by Shang et al, has investigated the effect of probiotics on mercury (Hg), which is a poisoning agent in both animal and fishes. Mercury is a potential oxidative stress inducer, as it exerts high toxicity against enzymes involved in antioxidants regulation.…”

Section: Reducing the Oxidative Stressmentioning

confidence: 99%

Probiotic Intervention in the Treatment of Diabetes Mellitus: A Review

Sreepathi¹,

Jayanthi²,

Chandra³

et al. 2022

J. Pure Appl. Microbiol.

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Diabetes is a noncommunicable lifestyle condition that impacts millions of individuals worldwide. Diabetes is a physiological illness that affects several different organs in the human body. Several studies have found a direct relationship between gut microbiota and diabetes control. Probiotic intervention in the treatment of diabetes mellitus has been the center of focus in the current scenario. Alteration in composition and metabolic activity of gut microbiota significantly contributes to human health. However, the key mechanism of gut microbiota in the inhibition of diabetes is not fully understood. This review discusses the effect of probiotics on diabetes and the role of gut microbiota. It emphasizes on the pharmacological effects of probiotics on diabetic symptoms like glycemic response, hypercholesterolemia, hypertension, as well as gestational diabetes.

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Effect of probiotic supplementation on oxidative stress markers in rats with diclofenac-induced hepatotoxicity

Cited by 13 publications

References 21 publications

Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma

Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma

Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine‐rich protein 2

Probiotic Intervention in the Treatment of Diabetes Mellitus: A Review

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