Effect of probiotic fermented milk and chlorophyllin on gene expressions and genotoxicity during AFB1-induced hepatocellular carcinoma

Chemopreventive Potential of Chlorophyllin: A Review of the Mechanisms of Action and Molecular Targets

“…CHL was found to enforce nuclear localization of the IAP protein survivin, an event that facilitates apoptosis by inhibiting caspases and inducing p53 and Bax (38). These findings are substantiated by reports of CHL-induced apoptosis induction in cancer cells in vitro and in animal tumor models in vivo (26,32,35,63). Thus, it appears that CHL promotes apoptosis by modulating the expression of a multitude of molecules involved in the apoptotic signaling cascade.…”

Exopolysaccharides: Sweet success with probiotic therapeutics

“…Kefiran treatment also resulted in changes in serum IL-4, IL-6, IL-10, and IFN, but not TNF or IL-12 [41] . Interestingly, Madrano et al [42] also observed an increase in peritoneal and lamina propria F4/80 + macrophages in mice fed kefiran. These data and those described above with B. fragilis PSA highlight how mucosal application of bacterial products can have both local and systemic effects on several types of immune cells.…”

“…These data and those described above with B. fragilis PSA highlight how mucosal application of bacterial products can have both local and systemic effects on several types of immune cells. Several studies have examined the beneficial effects of kefir on cancer [42] and high blood pressure [43] ; future studies are needed to assess if kefiran is responsible for the health promoting ability of kefir and to elucidate the host pathways involved.…”

Current evidence on the use of probiotics in liver diseases

“…Similar data from murine data with L. rhamnosus GG were reported. Particularly after aflatoxin exposure, lower expression of c-myc, cyclin D1, bcl-2 and rasp-21/g3pdh were found (Kumar et al, 2011). …”