Chemopreventive Potential of Chlorophyllin: A Review of the Mechanisms of Action and Molecular Targets

Nagini, Siddavaram; Palitti, F.; Natarajan, A.T.

doi:10.1080/01635581.2015.990573

Cited by 49 publications

(36 citation statements)

References 65 publications

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“…SCC salts (Fig. 5) inhibit cancer initiation and progression by targeting multiple molecules and pathways involved in the metabolism of carcinogens, cell cycle progression, apoptosis evasion, invasion, and angiogenesis [101]. One of the first in vivo evidences about the anticarcinogenic effects of SCC was conducted with rainbow trout.…”

Section: Antimutagenic/antigenotoxic Activitymentioning

confidence: 99%

Chemistry in the Bioactivity of Chlorophylls: An Overview

Pérez‐Gálvez

Viera

Roca

2018

CMC

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Section: Antimutagenic/antigenotoxic Activitymentioning

confidence: 99%

Chemistry in the Bioactivity of Chlorophylls: An Overview

Pérez‐Gálvez

Viera

Roca

2018

CMC

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“…The mitochondria‐mediated caspase cascade (also known as intrinsic pathway) involves mitochondrial membrane permeability change that triggers release of cytochrome c and other proapoptotic molecules from mitochondria to the cytosol. The released cytochrome c can bind apoptotic protease–activating factor 1, resulting in the generation of apoptosome‐dATP–dependent complex . This complex can activate caspase‐9, which in turn can cleave downstream effector caspases.…”

Section: Discussionmentioning

confidence: 99%

Taurine abrogates mammary carcinogenesis through induction of apoptosis in Sprague‐Dawley rats

Vanitha

Anandakumar

Sakthisekaran

2018

J Biochem & Molecular Tox

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Breast cancer is one of the most severe problems in oncology. Taurine is a sulfur-containing amino acid with vital biological functions. The current study was intended to investigate the abnormalities in the expression of apoptosis-associated proteins that lead to the progression of 7,12-dimethyl benz[a]anthracene (DMBA)-induced breast cancer and to expose the protective effect of taurine on it. Rats were induced with DMBA by gastric intubation to induce breast cancer. Breast cancer-bearing animals were posttreated with taurine. The breast tumors induced by DMBA, analyzed in the current study, were characterized by increased protein/DNA expression of Bcl-2 associated with downregulation in the expression of p53, Bax, and caspases. Taurine treatment reverted all the above changes induced by DMBA and inhibited the development of rat breast carcinoma through its ability to induce apoptosis.

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“…Below we review literature data related to toxicology and medicinal effects of chlorophylls and their derivatives first of all in humans. The role of dietary Chl metabolites and derivatives in animals and humans is reviewed in detail elsewhere [115,125,[168][169][170]. Ideally, medicinal studies with Chl derivatives should use a single compound with verified purity and/or with stable and well-characterized composition [171,172].…”

Section: Health Promoting and Medicinal Effectsmentioning

confidence: 99%