Effect of Probiotic Bacteria on Aflatoxins in Broiler Chickens: Growth Performance, Serum Parameters and Histological Alterations

Abstract

The main objective of this study was to evaluate aflatoxin (AFs) removal ability of probiotic bacteria. Two hundred and seventy one-day-old (Ross 308) broiler chicks were randomly distributed among nine groups. The dietary treatments were: 1 control; 2&3 artificially contaminated diets with 0.5&1mg of AFs, respectively; 4&5 received oral gavages anaerobic caecal culture (probiotic). 6, 7, 8&9 AFscontaminated diets plus probiotic feed additive (AFS-PB). The criteria of evaluation included body weight gain (BWG), Feed consumption (FC), and feed conversion ratio (FCR). The toxic effects of aflatoxins were apparently in groups received AFs contaminated diet which showed significantly lower BWG and FC and impaired FCR compared with control diet. Such effects overcome by adding probiotic bacteria to aflatoxin treated groups. On the other hand, AFs treated group showed significant increased in serum liver function enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST)), urea and creatinine levels. The intakes of probiotic bacteria significantly alleviated the elevation of ALT, AST, urea and creatinine levels. The results indicated the effect of probiotic as a potential protective agent against aflatoxin toxicity to decrease the risk of occurrence of liver and kidney dysfunction and occurrence of cancer and protect against both membrane and DNA damage.

Does the Use of Different Types of Probiotics Possess Detoxification Properties Against Aflatoxins Contamination in Rabbit Diets?

“…El-Afifi et al [ 53 ] revealed that probiotics decreased the effect of AF on body weight gain and improved blood parameters, liver function, and renal function. Probiotic results support their findings.…”

Detoxification Impacts of Dietary Probiotic and Prebiotic Supplements Against Aflatoxins: An Updated Knowledge – A Review

“…Furthermore, Marai and Asker (2008) hypothesized that aflatoxin's negative effects on immunity could reduce globulin levels. As a result, probiotics enhanced blood parameters, renal performance, and liver functions while reducing the impact of AF on body weight increase, as demonstrated by El-Afifi et al (2013).…”