Effect of pretreatment with matrix metalloproteinase inhibitors on the durability of bond strength of fiber posts to radicular dentin

Abstract

Objectives Application of matrix metalloproteinases inhibitors has been suggested to improve the durability of resin–dentin bonding. The purpose of this study was to evaluate the effect of dimethyl sulfoxide (DMSO), carbodiimide (EDC), and chlorhexidine (CHX) treatment on the push‐out bond strength of fiber posts to radicular dentin. Materials and Methods 24 extracted premolars were assigned randomly to 4 groups after root canal treatment and post space preparation (n = 6). In the first, second, and third groups, radicular dentin was treated with 1 ml of 5% DMSO, 0.3 M EDC, and 2% CHX, respectively. The fourth group (control) received no treatment. The root canals were primed with ED primer II, and the fiber posts were cemented with Panavia F2.0. In each group, half of the specimens were subjected to the push‐out test and the other half to 3000 thermal cycles before testing. Data were analyzed using two‐way analysis of variance via SPSS version 20 (p < .05). Results Among the nonthermocycled specimens, the values of push‐out bond strength were observed in the control, EDC, CHX, and DMSO groups, in decreasing order. Among the thermocycled specimens, the values were observed in the control, EDC, DMSO, and CHX groups in decreasing order. Thermocycling had a significant adverse effect on the push‐out bond strength (p = .015), but the effect of material (p = .375), and the interaction effect of material and thermocycling (p = .998) were not significant. Conclusions Application of CHX, DMSO, and EDC had no significant effect on the bond strength of fiber posts to radicular dentin.

Papel de las metaloproteinasas e inhibidores en la adhesión: Revisión literaria

“…Es el inhibidor de MMP más estudiado según la literatura y actúa como inhibidor no específico de las MMP mediante la quelación de iones metálicos (Ca 2+ , Zn 2+ ) y la alteración de la estructura tridimensional de la enzimas (Ghazvehi et al, 2022). Al ser aplicada directamente sobre la dentina posterior al grabado con ácido o incorporada en la composición del adhesivo, aun en concentraciones bajas se ha evidenciado que la CHX mantiene la integridad de la capa híbrida aumentando de este modo la fuerza de unión entre la dentina y la resina, se recomiendan concentraciones de al 2% y al 0,2% para lograr estos resultados.…”