Effect of preoperative prednisolone on clinical postoperative symptoms after surgical extractions of mandibular third molars

Abstract

Background: This study compared postoperative symptoms in patients treated preoperatively with a single dose of £20 mg oral steroid during third molar surgery. Methods: A total of 450 patients were categorized randomly into three groups containing 150 patients each. Patients were in their second or third decade and had no specific medical history and findings involving infections of the mandibular third molar area. Two groups received preoperative steroids orally one hour before the operation; one group received 10 mg prednisolone and the other received 20 mg. No steroids were administered to the control group. Patients were asked to report by questionnaire any changes in postoperative symptoms, such as pain, facial oedema, or gastrointestinal disorders, and in masticatory disorders, trismus, or swallowing discomfort. They reported daily from days 1 to 6 post-extraction by evaluating their experience over the preceding 24 hours. Results: A single preoperative oral administration of £20 mg prednisolone had no significant effect on postoperative symptoms of pain, facial oedema, or gastrointestinal upset, or on masticatory symptoms, trismus, or swallowing discomfort in mandibular third molar surgery. Conclusions: A single oral dose of £20 mg prednisolone before third molar extraction may not be helpful for the relief of postoperative symptoms.

A Single Dose of Amoxicillin and Dexamethasone for Prevention of Postoperative Complications in Third Molar Surgery: A Randomized, Double-Blind, Placebo Controlled Clinical Trial

“…Similarly to what was found in the present study, Kang at al [29] also observed that corticoid (20 mg of prednisolone) used as a single preoperative oral administration had no significant effect on postoperative symptoms of pain, facial edema and trismus in M3 surgeries. Besides the differences between methodological approaches, both studies evaluated the degree of postoperative symptoms using a self-reported VAS scores including pain and facial edema.…”

Comparison Of The Effect Of Two-dose And One-dose Dexamethasone On Post-inflammatory Complications In Third Molar Surgery

“…This study showed better pain and mouth opening control with steroid groups than with the non-steroid control group, even though these effects were not significant (significant only for pain st on 1 day; between 2-dose and control). The study is 11,14,24,25 in agreement with similar studies which also reported improvement in mouth opening but otherwise insignificant difference between the steroid and non-steroid groups. This is, however, contrary to some studies that reported that there is a significant difference between the steroid and non-steroid groups in term 26,27 of pain and trismus.…”

“…A total of 84 subjects that completed the study were included in the analysis, attrition rate was 12 16 (19%) were males while 68 (81%) were females in the ratio of 1 to 4. 25. Most, 40 (47.6%) of the teeth were in the category of "moderate" difficulty (using Pederson scale).…”

Effect of Various Routes of Administration of Methyl Prednisolone on Swelling, Trismus and Pain in Impacted Mandibular Third Molar Surgery

“…The mean reduction in inter-incisal opening on first post-operative day for all three groups of methylprednisolone was observed to be 14.83 % as compared to control group. Statistically significant findings have been ducumented when corticosteroids are used in combination with drugs like Diclofenac potassium for reducing pain and swelling, but not in reference to trismus by Bamgbose BO et al 12 López-Carriches C et al 26 in his study using methylprednisolone and diclofenac, concluded that the trismus may retain for up to 10 days after surgery.…”

“…A study involving three groups of patients (control and the administration of 10 and 20 mg of prednisolone) presented insignificant differences in pain among the groups (Kang SH et al 26 ).…”